Results 81 to 90 of about 7,898 (167)

Higher levels of serum α-Klotho are longitudinally associated with less central obesity in girls experiencing weight gain

Frontiers in Endocrinology, 2023
IntroductionKlotho is an anti-aging protein that reduces adiposity and increases caloric expenditure, among others. Although associations between secreted α-Klotho levels and obesity have been described, its relationship with central obesity and visceral
Gemma Carreras-Badosa, Elsa Puerto-Carranza, Berta Mas-Parés, Ariadna Gómez-Vilarrubla, Bernat Gómez-Herrera, Ferran Díaz-Roldán, Elena Riera-Pérez, Francis de Zegher, Lourdes Ibañez, Lourdes Ibañez, Judit Bassols, Abel López-Bermejo, Abel López-Bermejo, Abel López-Bermejo   +13 more
doaj   +1 more source

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom [PDF]

, 2018
Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these ...
Arnold, Walter, Johnson, Richard J., Kuro-o, Makoto, Lanaspa, Miguel, Painer, Johanna, Ruf, Thomas, Shiels, Paul G., Stenvinkel, Peter   +7 more
core   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Cross-Sectional Analysis in the EPIC-Germany Study [PDF]

, 2015
Background Increased fibroblast growth factor 23 (FGF23), a bone-derived hormone involved in the regulation of phosphate and vitamin D metabolism, has been related to the development of cardiovascular disease (CVD) in chronic kidney disease patients and ...
Boeing, Heiner, Buijsse, Brian, Dierkes, Jutta, Fritsche, Andreas, Giuseppe, Romina di, Hirche, Frank, Kaaks, Rudolf, Kühn, Tilman, Stangl, Gabriele I., Weikert, Cornelia   +9 more
core   +1 more source

Effect of Two Therapeutic Renal Diets on Hormonal and Regulatory Pathways Affecting Calcium Homeostasis in Cats With Early‐Stage Chronic Kidney Disease

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Chronic kidney disease (CKD) is a known risk factor for hypercalcemia in cats. Phosphate‐restricted diets have also been implicated in causing hypercalcemia, in part because phosphate restriction increases the Ca:P ratio. The primary objective of this study was to evaluate the impact of two different therapeutic renal foods on ionized (iCa ...
Jean A. Hall, Elizabeth M. Morris, Dale A. Fritsch, John J. Brejda, Kim M. Wilson   +4 more
wiley   +1 more source

The Role of Wnt Signaling in Age‐Related Alveolar Bone Loss and Regeneration

Journal of Periodontal Research, EarlyView.
The graphical abstract summarizes key signaling pathways involved in bone formation and resorption associated with Wnt signaling across young and aged long bone and jaw tissues. Levels of evidence are indicated as robust, moderate, or emerging, reflecting the current experimental support in each context.
Hsiao H. Sung, Navya Chalamalasetty, Ali Alzainal, Hanlong Liu, Lexuan Wang, Pietra Colacrai Arikita, Ivy C. X. Wei, Hom‐Lay Wang, M. H. J. van den Bosch, Michelle S. Caird, Peter M. van der Kraan, Kenneth M. Kozloff, Esmeralda Blaney Davidson   +12 more
wiley   +1 more source

Relationship between uric acid to high-density cholesterol ratio (UHR) and circulating α-klotho: evidence from NHANES 2007–2016

Lipids in Health and Disease
Objective To investigate the relationship between uric acid to high-density lipoprotein cholesterol ratio (UHR) and circulating α-klotho levels in U.S. adults.
Xuanchun Huang, Lanshuo Hu, Shiyi Tao, Tiantian Xue, Chengzhi Hou, Jun Li   +5 more
doaj   +1 more source

Seven days of warm‐water immersion enhances resting irisin and BDNF, but not klotho, in older men

Experimental Physiology, EarlyView.
Abstract We examined whether seven consecutive days of warm‐water immersion could elevate resting and exercise‐induced levels of brain‐derived neurotrophic factor (BDNF), irisin and klotho in older adults. These biomarkers support cognitive and metabolic health, but their levels decline with age.
Joel M Garrett, James J McCormick, Kelli E King, Kristina‐Marie T Janetos, Nathalie V Kirby, Fergus K O'Connor, Glen P Kenny   +6 more
wiley   +1 more source

Chronic Hyperphosphatemia and Vascular Calcification Are Reduced by Stable Delivery of Soluble Klotho [PDF]

, 2016
αKlotho (αKL) regulates mineral metabolism, and diseases associated with αKL deficiency are characterized by hyperphosphatemia and vascular calcification (VC).
Bhaskaran, Manoj, Cass, Taryn A., Clinkenbeard, Erica L., Cramer, Martin S., Hum, Julia M., Johnson, Robert L., O’Bryan, Linda M., Smith, Rosamund C., Tatiparthi, Arun K., White, Kenneth E., Wilson, Jonathan M.   +10 more
core   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source