Results 81 to 90 of about 741,770 (157)

Inverted U-shaped relationship between serum vitamin B12 and α-Klotho levels in US adults: a cross-sectional study

Frontiers in Nutrition
BackgroundSerum vitamin B12 and α-Klotho are important markers associated with aging. Limited studies have been conducted on the relationship between vitamin B12 and α-Klotho.ObjectivesThis study investigated the relationship between circulating α-Klotho
Yu-shan Li, Xing-ji Gong, Wen-jie Du, Yang Li, Dong-yong He, Jian Yao, Cui Bai   +6 more
doaj   +1 more source

Expression of α-Klotho protein in human thyroid cancers — an immunohistochemical study

, 2019
Introduction: The α-Klotho protein was discovered as a gene controlling the process of aging, but further studies indicated that it also plays the role of a tumour suppressor.
Winczyk, Katarzyna; Department of Neuroendocrinology, Medical University of Lodz, Poland, Pisarek, Hanna; Department of Neuroendocrinology, Medical University of Lodz, Poland, Pawlikowski, Marek; Department of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Lodz, Poland, Borkowska, Magdalena; Department of General and Endocrinological Surgery, Copernicus Memorial Hospital, Lodz, Poland   +3 more
core   +1 more source

Association of body roundness index, serum α-Klotho and osteoarthritis: A nationwide population-based study of middle-aged and older adults

Experimental Gerontology
Background: Previous research has identified associations between the body roundness index (BRI), a novel marker of abdominal obesity, and serum α-Klotho levels with osteoarthritis (OA).
Wentian Gao, Yu Zhang, Yuejian Ding, Qiangqiang Li, Qing Jiang, Dongyang Chen   +5 more
doaj   +1 more source

Reduction of Oxidative Stress in Chronic Kidney Disease Does Not Increase Circulating α-Klotho Concentrations. [PDF]

, 2016
The CKD-associated decline in soluble α-Klotho levels is considered detrimental. Some in vitro and in vivo animal studies have shown that anti-oxidant therapy can upregulate the expression of α-Klotho in the kidney. We examined the effect of anti-oxidant
Nanayakkara, Prabath W., Piet M Ter Wee, Vervloet, M.G., Martin H de Borst, Annemieke C. Heijboer (495806), Aaltje Y Adema, Marc G Vervloet, Wee, P.M. Ter, Heijboer, Annemieke C., Frans J. van Ittersum (755509), Frans J van Ittersum, Prabath W Nanayakkara, Hoenderop, J.G.J., Martin H. de Borst (123754), Adema, A.Y., van Ittersum, Frans J., Hoenderop, Joost G., de Borst, Martin H., Aaltje Y. Adema (848101), Joost G Hoenderop, NIGRAM consortium, Nanayakkara, P.W., Prabath W. Nanayakkara (848102), Marc G. Vervloet (829815), Borst, M.H. de, Joost G. Hoenderop (225674), Ittersum, F.J. van, Vervloet, Marc G., Adema, Aaltje Y., Heijboer, A.C., Annemieke C Heijboer, de Borst, Martin H.; id_orcid, Ter Wee, Piet M., Piet M. Ter Wee (3286980)   +33 more
core   +1 more source

Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice

Heliyon, 2019
α-Klotho, a known anti-aging protein, exerts diverse physiological effects including: maintenance of phosphate and calcium homeostasis, modulation of cell proliferation, and enhanced buffering of reactive oxygen species.
Zhijian Rao, Taylor Landry, Peixin Li, Wyatt Bunner, Brenton Thomas Laing, Yuan Yuan, Hu Huang   +6 more
doaj   +1 more source

α-Klotho levels in girls with central precocious puberty: potential as a diagnostic and monitoring marker

Frontiers in Endocrinology
BackgroundRecent studies suggest a link between the Klotho protein, sex hormones, and insulin-like growth factor-1 (IGF-1), indicating that α-Klotho levels may rise during puberty, including in central precocious puberty (CPP) cases.
Jun-Hong Park, Eu-Seon Noh, Il Tae Hwang
doaj   +1 more source

Circulating Kisspeptin and Klotho Levels in Women with Hyperprolactinemia

Endocrinology Research and Practice, 2022
Objective: Kisspeptin is a neuropeptide that acts mainly on gonadotropin-releasing hormone in the hypothalamus with neurokinin B and dynorphin. Also, its peripheral effects have gained importance in recent years.
İsmail Emre Arslan, Beyza Olcay Öztürk, Başak Bolayır, Mehmet Muhittin Yalçın, İlhan Yetkin, Müjde Aktürk   +5 more
doaj  

Table_2_Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice.DOCX

, 2019
The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular ...
Thomas Behnisch (355864), Ying Chen (9697), Fang Huang (154302), Dongqing Jing (6533705), Ziyang Liu (242055), Dongxue Li (835305)   +5 more
core   +1 more source

Serum Soluble α Klotho and FGF 23 levels in Chronic Kidney Disease [PDF]

, 2019
BACKGROUND: Chronic kidney disease is an emerging global health issue with prevalence between 11 to 13%. Pathological variations of Klotho – FGF 23 in chronic kidney disease are implicated as clinical biomarkers and may bring forth novel therapeutic ...
Kalpana, D
core  

Table_1_Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice.DOCX

, 2019
The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular ...
Thomas Behnisch (355864), Ying Chen (9697), Fang Huang (154302), Dongqing Jing (6533705), Ziyang Liu (242055), Dongxue Li (835305)   +5 more
core   +1 more source