Results 101 to 110 of about 7,898 (167)

PO-171 New insights into exercise intervention for chronic diseases: by promoting α-Klotho expression [PDF]

, 2018
Objective A new view is proposed for the mechanism of exercise prevention and improvement of chronic disease, that exercise may play a role by promoting the expression of anti-aging protein α-Klotho.
Li, Ankang, Zuo, Qun
core   +2 more sources

Association of body roundness index, serum α-Klotho and osteoarthritis: A nationwide population-based study of middle-aged and older adults

Experimental Gerontology
Background: Previous research has identified associations between the body roundness index (BRI), a novel marker of abdominal obesity, and serum α-Klotho levels with osteoarthritis (OA).
Wentian Gao, Yu Zhang, Yuejian Ding, Qiangqiang Li, Qing Jiang, Dongyang Chen   +5 more
doaj   +1 more source

Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice

Heliyon, 2019
α-Klotho, a known anti-aging protein, exerts diverse physiological effects including: maintenance of phosphate and calcium homeostasis, modulation of cell proliferation, and enhanced buffering of reactive oxygen species.
Zhijian Rao, Taylor Landry, Peixin Li, Wyatt Bunner, Brenton Thomas Laing, Yuan Yuan, Hu Huang   +6 more
doaj   +1 more source

α-Klotho levels in girls with central precocious puberty: potential as a diagnostic and monitoring marker

Frontiers in Endocrinology
BackgroundRecent studies suggest a link between the Klotho protein, sex hormones, and insulin-like growth factor-1 (IGF-1), indicating that α-Klotho levels may rise during puberty, including in central precocious puberty (CPP) cases.
Jun-Hong Park, Eu-Seon Noh, Il Tae Hwang
doaj   +1 more source

Association between plasma trans fatty acids and serum α-klotho levels in adults in the United States of America: an analysis of the NHANES 2009–2010 datasets

Lipids in Health and Disease
Background This study aimed to explore the potential associations between trans fatty acid (TFA) and α-klotho levels. Methods Datasets from the 2009–2010 National Health and Nutrition Examination Survey (NHANES) were analysed for this study ...
Yali Liang, Yu Zhu, Min Zhang, Yuxiao Zhang, Shanjiamei Jiang, Xinzhi Wang, Fan Yu, Jie Ma, Yue’e Huang   +8 more
doaj   +1 more source

The relationship between serum alpha-klotho levels and urinary incontinence in middle-aged and older females: insights from NHANES

Scientific Reports
Urinary incontinence (UI) in females is a prevailing condition that affects individuals across various age groups and is not limited to older females. The presence of serum alpha-Klotho (α-klotho) serves as a reliable biomarker to indicate the effects of
Xiaoyan Tang, Yanhua Song, Hao Liang, Wenjin He, Zili Chen, Li Yang, Cheng Yang, Rui Du   +7 more
doaj   +1 more source

Association between serum alpha Klotho levels and the likelihood of abdominal aortic calcification

Scientific Reports
As an anti-aging protein, alpha Klotho (α-Klotho) plays an important role in cardiovascular disease. However, the correlation between α-Klotho and abdominal aortic calcification (AAC) is unclear.
Dan Liang, Chang Liu, Mei Yang
doaj   +1 more source

The prognostic value of serum α-klotho in age-related diseases among the US population: A prospective population-based cohort study

Preventive Medicine Reports
Objective: α-Klotho is a potential biological marker of aging with satisfactory clinical applicability. However, its prognostic significance in age-related diseases has largely been undermined.
Zhiwen Yang, Yusheng Ma, Yanbing Wang, Ming Jin, Jianping Bin, Zhiyong Chen, Zhonghua Teng   +6 more
doaj   +1 more source

Association between methylmalonic acid and Alpha-Klotho in American adults: A cross-sectional study.

PLoS ONE
ObjectivesMethylmalonic acid is a surrogate biomarker of mitochondrial dysfunction and oxidative stress. Serum soluble α-Klotho, as a key anti-aging factor, is regarded as one of the biomarkers of aging.
Ronghui Bao, Hongyan Qi, Lei Liao, Qinqin Yu, Jie Li, Rong Liu, Chang Zhou   +6 more
doaj   +1 more source

Association between serum α-Klotho levels and tinnitus stratified by sex and depression: A cross-sectional study from NHANES. [PDF]

Medicine (Baltimore)
Zhang X, Gao Z, Zhang Y, Liu G, Zhang Y, Chi N, Zhang J, Wu Y, Qi Z, Ding D.   +9 more
europepmc   +1 more source