Results 91 to 100 of about 7,898 (167)
Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells [PDF]
, 2017 BACKGROUND: Systemic sclerosis (SSc) is characterized by endothelial cell (EC) apoptosis, impaired angiogenesis and peripheral microvasculopathy. Soluble α-Klotho (sKl) is a pleiotropic molecule with multiple effects on ECs, including antioxidant and ...
Bellando Randone, Silvia +10 more
core +1 more source
Diabetes/Metabolism Research and Reviews, Volume 42, Issue 4, May 2026.Central illustration: Pathophysiological mechanisms linking diabetes mellitus and cardiovascular disease. Chronic hyperglycaemia, insulin resistance, and low‐grade inflammation contribute to endothelial dysfunction, myocardial fibrosis, and cardiomyocyte apoptosis.
Lilian Anagnostopoulou +13 more
wiley +1 more source
α-Klotho Expression in Mouse Tissues Following Acute Exhaustive Exercise
Frontiers in Physiology, 2019 α-Klotho, a multifunctional protein, has been demonstrated to protect tissues from injury via anti-oxidation and anti-inflammatory effects. The expression of α-klotho is regulated by several physiological and pathological factors, including acute ...
Zhijian Rao +6 more
doaj +1 more source
Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions
MedComm, Volume 7, Issue 5, May 2026.We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu +8 more
wiley +1 more source
Obesity, Volume 34, Issue 5, Page 1068-1080, May 2026.ABSTRACT Objective This study aimed to assess iron oxide magnetic nanoparticles (MNPs) for adipose tissue‐targeted therapeutics to restore adipose tissue function and insulin sensitivity in obesity. Methods The insulin‐sensitizing effects of rosiglitazone and known adverse effects were leveraged for this proof‐of‐concept assessment of adipose tissue ...
Jakob E. Ostberg +6 more
wiley +1 more source
Cell Proliferation, Volume 59, Issue 5, May 2026.This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang +10 more
wiley +1 more source
Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases [PDF]
, 2017 Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases.
Alkozi, Hanan Awad +2 more
core +2 more sources
Journal of Diabetes Investigation, Volume 17, Issue 5, Page 766-780, May 2026.This TriNetX (US, 2016–2023) study compared clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes treated with GLP‐1 receptor agonists vs DPP4 inhibitors. ABSTRACT Objectives To evaluate whether glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are associated with improved survival and renal outcomes in patients with ...
Yu‐Ting Yu +4 more
wiley +1 more source
Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation. [PDF]
, 2020 Skeletal muscle is among the most age-sensitive tissues in mammal organisms. Significant changes in its resident stem cells (i.e., satellite cells, SCs), differentiated cells (i.e., myofibers), and extracellular matrix cause a decline in tissue ...
Conboy, Irina M +4 more
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Na依存性PiトランスポーターNpt2cは、KlothoノックアウトマウスPi恒常性において成長期と成熟期では異なる作用を有する [PDF]
, 2021 SLC34A3/NPT2c/NaPi-2c/Npt2c is a growth-related NaPi cotransporter that mediates the uptake of renal sodium-dependent phosphate (Pi). Mutation of human NPT2c causes hereditary hypophosphatemic rickets with hypercalciuria.
Amizuka, Norio +13 more
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