Results 71 to 80 of about 7,246 (143)

The Binding of Fibroblast Growth Factor 23 (FGF23) to FGF Receptor‐αKlotho Complex Increases Sinoatrial Electrical Activity

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim This study aims to investigate whether the Fibroblast Growth Factor 23 (FGF23) modulates the electrical activity of sinoatrial (SAN) cells. The canonical function of FGF23 is to regulate body phosphorus and calcium homeostasis by activating the FGF1 receptors (FGFR1)/α‐Klotho complex in the kidney and parathyroid glands.
Giorgia Bertoli, Patrizia Benzoni, Serena Canzolino, David Molla, Raffaella Milanesi, Chiara Piantoni, Makoto Kuro‐o, Carmen Delgado, Gema Ruiz‐Hurtado, Mirko Baruscotti, Annalisa Bucchi   +10 more
wiley   +1 more source

Circulating Kisspeptin and Klotho Levels in Women with Hyperprolactinemia

Endocrinology Research and Practice, 2022
Objective: Kisspeptin is a neuropeptide that acts mainly on gonadotropin-releasing hormone in the hypothalamus with neurokinin B and dynorphin. Also, its peripheral effects have gained importance in recent years.
İsmail Emre Arslan, Beyza Olcay Öztürk, Başak Bolayır, Mehmet Muhittin Yalçın, İlhan Yetkin, Müjde Aktürk   +5 more
doaj  

Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Aging is a systemic decline in physiological integrity, driving chronic diseases such as neurodegeneration, cardiovascular disorders, and metabolic syndromes. Rapid global population aging urgently demands effective interventions. Traditional Chinese medicine (TCM) formulas, characterized by multi‐component, multi‐target, and multi‐pathway ...
Chenrong Jin, Ding Du, Xiaorui Yu, Xiaoyan Ji, Xiuyun Zhang, Anning Li, Shuang Zu, Bo Qu, Daqing Zhao, Dianpeng Wu, Meichen Liu   +10 more
wiley   +1 more source

Fenofibrate Protects Against Antipsychotic‐Induced Hyperglycemia Through Weight Loss and FGF21 Dependent Mechanisms

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
The proposed mechanism through which fenofibrate protects against olanzapine‐induced hyperglycemia in mice. ABSTRACT Antipsychotic (AP) medications, such as olanzapine, cause acute weight gain independent of hyperglycemia through a glucagon‐dependent mechanism.
Michael Akcan, Stewart Jeromson, Bradley J. Baranowski, Annalaura Bellucci, Serena Trang, Katelyn Eisner, Ailish Babicki‐Moore, Hadil Alfares, Meagan Arbeau, Kyle Medak, Margaret Hahn, David C. Wright   +11 more
wiley   +1 more source

Association between smoking, smoking cessation and serum α-klotho levels among American adults: National Health and Nutrition Examination Survey.

PLoS ONE
α-klotho is an anti-aging protein. The correlation between smoking, smoking cessation and serum α-klotho levels remains controversial. The aim of this study was to investigate the association between smoking, smoking cessation and serum α-klotho levels ...
Ting Liu, Meihua Song, Jie Li, Yumei Zhao, Weiming Zhong   +4 more
doaj   +1 more source

Association between plasma trans fatty acids and serum α-klotho levels in adults in the United States of America: an analysis of the NHANES 2009–2010 datasets

Lipids in Health and Disease
Background This study aimed to explore the potential associations between trans fatty acid (TFA) and α-klotho levels. Methods Datasets from the 2009–2010 National Health and Nutrition Examination Survey (NHANES) were analysed for this study ...
Yali Liang, Yu Zhu, Min Zhang, Yuxiao Zhang, Shanjiamei Jiang, Xinzhi Wang, Fan Yu, Jie Ma, Yue’e Huang   +8 more
doaj   +1 more source

Investigation of α-Klotho Concentrations in Serum of Cats Affected by Hypertrophic Cardiomyopathy

Veterinary Sciences
Being involved in various physiological and pathophysiological mechanisms (ageing, kidney damage, cardiovascular diseases, etc.), Klotho is a parameter of increasing interest.
Stephan Neumann, Stephan Siegert
doaj   +1 more source

Association of α-klotho concentrations with cardiovascular and all-cause mortality in American adults with depression: a national prospective cohort study

Translational Psychiatry
This study examines α-klotho levels in depressed American adults and their association with cardiovascular disease and all-cause mortality, utilizing data from the National Health and Nutrition Examination Survey (2007–2016) and mortality details from ...
Jiayu Zhao, Tong Zhou, Yang Jing, Jiarui Shao, Cailin Xie, Yingying Huang, Tian Long, Jiaming Luo   +7 more
doaj   +1 more source

The relationship between serum alpha-klotho levels and urinary incontinence in middle-aged and older females: insights from NHANES

Scientific Reports
Urinary incontinence (UI) in females is a prevailing condition that affects individuals across various age groups and is not limited to older females. The presence of serum alpha-Klotho (α-klotho) serves as a reliable biomarker to indicate the effects of
Xiaoyan Tang, Yanhua Song, Hao Liang, Wenjin He, Zili Chen, Li Yang, Cheng Yang, Rui Du   +7 more
doaj   +1 more source

Association between serum alpha Klotho levels and the likelihood of abdominal aortic calcification

Scientific Reports
As an anti-aging protein, alpha Klotho (α-Klotho) plays an important role in cardiovascular disease. However, the correlation between α-Klotho and abdominal aortic calcification (AAC) is unclear.
Dan Liang, Chang Liu, Mei Yang
doaj   +1 more source