Results 71 to 80 of about 7,898 (167)

Fibrosis of Peritoneal Membrane, Molecular Indicators of Aging and Frailty Unveil Vulnerable Patients in Long-Term Peritoneal Dialysis [PDF]

, 2023
Funding: Sociedade Portuguesa de Nefrologia (SPN) SPN funded a project and Ana Rita Martins, MD, Nephrology fellow, for a residence at Jiménez Díaz Foundation University Hospital, Madrid under the scope of novel serum biomarkers of CKD.
Azeredo-Lopes, Sofia, Branco, Patrícia, Calça, Rita, Civantos, Ester, De Melo Junior, Antonio Ferreira, Gaspar, Augusta, Gomes, Daniel Pinto, Jervis, Maria João, Martins, Ana Rita, Mas-Fontao, Sebastian, Mateus, Catarina, Morello, Judit, Nolasco, Fernando, Pereira, Sofia Azeredo, Ramos, Sância, Rodrigues, Anabela, Sousa, Cátia   +16 more
core   +2 more sources

Association between serum α‐Klotho levels and severity of periodontitis in a representative U.S. population

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis, a chronic inflammatory disease, is linked to systemic conditions such as cardiovascular and kidney disease. Serum α‐Klotho, an anti‐aging protein with anti‐inflammatory properties, has been associated with systemic diseases, but its role in periodontitis is unclear.
Hamoun Sabri, Sahar Baniameri, Pranav Kataria, Hend Abulatifa, Parham Hazrati, Hom‐Lay Wang, Muhammad H. A. Saleh   +6 more
wiley   +1 more source

Circulating α-Klotho is Related to Plasma Aldosterone and Its Follow-Up Change Predicts CKD Progression

Kidney & Blood Pressure Research, 2018
Background/Aims: We aimed to determine if soluble α-klotho level was an indicator of chronic kidney disease (CKD) progression and whether α-klotho interacted with aldosterone during the course of further renal damage.
Jing Qian, Jianyong Zhong, Minhua Yan, Ping Cheng, Huizhu Shi, Chuanming Hao, Yong Gu, Lingyun Lai   +7 more
doaj   +1 more source

L-shaped association of serum α-Klotho and frailty among the middle-aged and older adults: results from NHANES 2007–2016

BMC Geriatrics, 2023
Background Frailty is common and not limited to older age group. Serum α-Klotho works as a biomarker of anti-aging effect. However, there is limited research about the relationship between them in middle-aged and older people and controversy still exists.
Zewei Jiang, Jiaxin Wang, Xingdong Cai, Ping Wang, Shengming Liu   +4 more
doaj   +1 more source

Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake [PDF]

, 2016
Background: We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated
Bakhshi, Andisheh, Caslake, Muriel, Christensen, Kelly, Cooney, Josephine, Demou, Evangelia, Macdonald, Ewan, McClelland, Ruth, McGuinness, Dagmara, Mohammed, Suhaib, Shiels, Paul G., Stenvinkel, Peter   +10 more
core   +3 more sources

METTL14 Ameliorates Mitochondrial Dysfunction and Autophagy in Lens Epithelial Cells of Diabetic Cataracts via m6A Modification of RPL3

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li, Xue Wang, Wei Du, Qian Li, Hong‐Ping Cui   +4 more
wiley   +1 more source

The angiotensin-(1-7)/Mas receptor a xis protects from endothelial cell senescence via klotho and Nrf2 activation [PDF]

, 2019
Endothelial cell senescence is a hallmark of va scular aging that pre disposes to vascular disease. We aimed to explore the capacity of the renin-angiotensin system (RAS) heptapeptide angiotensin (Ang)-(1-7) to counteract human ...
Bartha, José Luis, Erusalimsky, Jorge, Hipólito-Luengo, Álvaro San, León, Rafael, Michalska, Patrycja, Pajuelo-Lozano, Natalia, Peiró, Concepción, Romacho, Tania, Romero, Alejandra, Sanz, María J., Sánchez-Ferrer, Carlos F., Sánchez-Pérez, Isabel, Valencia, Inés, Vallejo, Susana, Villalobos, Laura   +14 more
core   +4 more sources

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus

Cardiovascular Diabetology
Background Compelling evidence suggests that calcium/phosphorus homeostasis-related parameters may be linked to diabetes mellitus and cardiovascular events.
Jiao Bi, Mei Zheng, Ke Li, Siwei Sun, Zihang Zhang, Nana Yan, Xueping Li   +6 more
doaj   +1 more source

Correlation between serum α-Klotho levels and different stages of periodontitis

BMC Oral Health, 2023
Background Periodontitis is an inflammatory disease characterized by inflammation and progressive destruction of periodontal tissues including alveolar bone.
Can Ni, Dongyu Bao, Fuhua Yan, Bin Chen
doaj   +1 more source