Results 71 to 80 of about 741,770 (157)

Relationship between uric acid to high-density cholesterol ratio (UHR) and circulating α-klotho: evidence from NHANES 2007–2016

Lipids in Health and Disease
Objective To investigate the relationship between uric acid to high-density lipoprotein cholesterol ratio (UHR) and circulating α-klotho levels in U.S. adults.
Xuanchun Huang, Lanshuo Hu, Shiyi Tao, Tiantian Xue, Chengzhi Hou, Jun Li   +5 more
doaj   +1 more source

Podocyte mPGES‐2 Determines Renal Aging and Contributes to Senile Osteoporosis

Aging Cell, Volume 25, Issue 7, July 2026.
Podocyte mPGES‐2 drives renal aging through PGE2/EP1‐dependent senescence and disrupts renal endocrine support for bone homeostasis. Genetic deletion or pharmacological inhibition of mPGES‐2 protects aged mice from kidney dysfunction and osteoporosis. ABSTRACT Renal aging shortens healthspan and propagates organ dysfunction beyond the kidney, yet its ...
Dandan Zhong, Chang Hao, Mengyue Li, Jing Liu, Zheng Xu, Jianteng Zhou, Lu Zhao, Siyu Ni, Zhenchao Hu, Yue Sun, Yingying Zou, Dong Sun, Hao Guo, Zhanjun Jia, Dong Guo, Jun‐Li Cao, Ying Sun   +16 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, Volume 7, Issue 2, Page 52-66, June 2026.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Evaluate the Prognostic Value of serumγKlotho on Long‐Term Prognosis of Patients With Multivessel Coronary Artery Disease and Establish a Prognostic Model

Clinical Cardiology, Volume 49, Issue 6, June 2026.
Higher serum γKlotho level correlated with the poor prognosis of MVD patients, our predictive model exhibited better predictive ability and clinical usefulness. ABSTRACT Objective This study was aimed at analyzing the correlation of serum γKlotho with the long‐term prognosis of multivessel coronary artery disease (MVD) and develop a predictive model to
Tuersunjiang Naman, Yu‐ting Zhang, Ayinuer Maihemuti, Hui Cheng, Wen‐bo Fu, Xiao‐lin Yu, Zhao Wang, Yi‐ning Yang, Zi‐tong Guo   +8 more
wiley   +1 more source

Klotho and aging phenotypes

, 2021
It is well established that animal models of α-Klotho deficiency are characterized by an aging phenotype. With the advent of research in the biological mechanisms of aging it has become clear that the kidney-derived α-Klotho protein has a key role in ...
Hillebrands, Jan-Luuk; id_orcid, Jan-Luuk Hillebrands, Vervloet, Marc G., Hillebrands, Jan-Luuk, Marc G. Vervloet   +4 more
core   +1 more source

Circulating α-Klotho Levels Are Inversely Correlated to FGF-23 in Tumour Induced Osteomalacia [PDF]

, 2013
Tumour induced osteomalacia is characterised by high circulating levels of fibroblast growth factor 23 (FGF23) due to ectopic secretion from mesenchymal tumors.
Zeun, Paul, Washbourne, Christopher, Piec, Isabelle, Fraser, William, Tang, Jonathan   +4 more
core  

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Klotho, stem cells, and aging

, 2015
Ao Bian,1,2 Javier A Neyra,3 Ming Zhan,4 Ming Chang Hu1,3 1Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Nephrology, First Affiliated Hospital ...
Bian A, Zhan M, Hu MC, Neyra JA
core  

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, Volume 2, Issue 2, Page 309-342, June 2026.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Table_1_Association between perfluoroalkyl and polyfluoroalkyl internal exposure and serum α-Klotho levels in middle-old aged participants.DOCX

, 2023
PurposeExposure to perfluoroalkyl and polyfluoroalkyl substances causes oxidative stress, which is strongly associated with adverse health effects. Klotho protein plays an anti-aging role via antioxidation activity.MethodsWe investigated the levels of ...
Yuanlin Ma (3442139), Cheng Zhou, Luyun Zhang (4855912), Wenji Zhang, Luyun Zhang, Min Li (12799), Min Li, Wenli Cheng, Wenjuan Zhang, Cheng Zhou (307152), Wenji Zhang (5896706), Yuanlin Ma, Wenli Cheng (765705), Wenjuan Zhang (234517)   +13 more
core   +1 more source