Results 41 to 50 of about 741,770 (157)

Involvement of α-klotho in growth hormone (GH) signaling. [PDF]

J Clin Biochem Nutr
Growth hormone (GH) exerts multiple effects on different organs directly or via its main mediator, insulin-like growth factor1 (IGF1). In this study, we focused on the novel relationship between GH action and the antiaging hormone α-klotho ...
Koike M, Sato T, Shiozaki Y, Komiya A, Miura M, Higashi A, Ishikawa A, Takayanagi K, Uga M, Miyamoto KI, Segawa H.   +10 more
europepmc   +2 more sources

α-Klotho Expression in Human Tissues.

, 2015
CONTEXT: α-Klotho has emerged as a powerful regulator of the aging process. To date, the expression profile of α-Klotho in human tissues is unknown, and its existence in some human tissue types is subject to much controversy. OBJECTIVE: This is the first

core   +1 more source

Data_Sheet_1_Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease.CSV

, 2022
ObjectiveAccumulating experimental evidence has identified the beneficial effects of the anti-aging protein, serum soluble α-Klotho, on longevity, and the cardiovascular system.
Mu-Hua He (12894758), Min-Zhou Zhang (12254201), Rui-Xiang Zeng (12254189), Li-Heng Guo (12894764), Shan-Shan Lin (12894761), Jun-Peng Xu (12254186)   +5 more
core   +1 more source

Table_1_Serum α-Klotho associated with oral health among a nationally representative sample of US adults.docx

, 2022
BackgroundLow klotho is associated with aging-related traits. However, no study has assessed the association between klotho and oral health in a large sample of population.
Yao Duan (3345122), Ying Lian (334162), Xiu-Li Yin (2058487), Jin-Feng Wang (53314), Guo-Qiang Chen (262005)   +4 more
core   +1 more source

Association between daily alcohol consumption and serum alpha klotho levels among U.S. adults over 40 years old: a cross-sectional study

BMC Public Health, 2023
Background Klotho is a hormone considered to be an anti-aging biomarker. The relationships between daily alcohol consumption and serum klotho are mainly unknown.
Meihua Jiang, Xiaoyan Tang, Peng Wang, Li Yang, Rui Du   +4 more
doaj   +1 more source

Central α-Klotho Suppresses NPY/AgRP Neuron Activity and Regulates Metabolism in Mice

, 2020
α-Klotho is a circulating factor with well-documented anti-aging properties; however, the central role of α-klotho in metabolism remains largely unexplored.
Amber Prete (8712972), Brenton Thomas Laing (4730106), Ada Admin (8524211), Zhijian Rao (8712971), Julia Sylvestri (8712973), Wyatt Bunner (4730100), Hu Huang (349397), Peixin Li (4730109), Taylor Landry (4730097)   +8 more
core   +1 more source

α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid

Frontiers in Aging Neuroscience
IntroductionCSF α-klotho levels might affect Aβ40, Aβ42, and the Aβ42/40 ratio in the cerebrospinal fluid (CSF).MethodsCSF α-klotho was assayed in ovariectomized rhesus macaques (NHPs) maintained on a Western-style diet (WSD) to assess the effect of ...
Jacob Raber, Jacob Raber, Jacob Raber, Jacob Raber, Alexandra Pederson, Emily Bunnell, Nora Mattek, Nora E. Gray, Steven G. Kohama, Alison R. Weiss, Alison R. Weiss, Alison R. Weiss, Joseph F. Quinn, Henryk F. Urbanski, Henryk F. Urbanski, Henryk F. Urbanski   +15 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

The Protective Role of Klotho in CKD-Associated Cardiovascular Disease

Kidney Diseases, 2020
Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in advanced CKD. The major pathological changes of CKD-associated CVD are severe vascular media calcification, aberrant cardiac remodeling such as hypertrophy and
Xianjin Bi, Ke Yang, Bo Zhang, Jinghong Zhao   +3 more
doaj   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source