Klotho and lean mass as novel cardiovascular risk factors in hemodialysis patients [PDF]
, 2023 BACKGROUND: Patients with chronic kidney disease (CKD) present a higher risk of cardiovascular (CV) morbidity and mortality compared with the general population.
Azeredo-Lopes, Sofia +4 more
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Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease
Frontiers in Cardiovascular Medicine, 2022 ObjectiveAccumulating experimental evidence has identified the beneficial effects of the anti-aging protein, serum soluble α-Klotho, on longevity, and the cardiovascular system.
Jun-Peng Xu +11 more
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Furosemide stimulation of parathormone in humans: role of the calcium-sensing receptor and the renin-angiotensin system. [PDF]
, 2015 Interactions between sodium and calcium regulating systems are poorly characterized but clinically important. Parathyroid hormone (PTH) levels are increased shortly after furosemide treatment by an unknown mechanism, and this effect is blunted by the ...
Anex, C. +8 more
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Skeletal muscle as a regulator of the longevity protein, Klotho [PDF]
, 2014 Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been ascribed to exercise and physical activity.
Ambrosio, F +8 more
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Analytical Cellular Pathology, 2019 Background and Aims. Klotho is an aging-suppressor gene mainly expressed in the renal tubules. The klotho gene encodes the α-klotho protein, which has many functions. Previous studies have found that α-klotho protein has a cardiorenal protective function.
Xi Liu +7 more
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Association of α-klotho with subclinical carotid atherosclerosis in subjects with type 1 diabetes mellitus [PDF]
, 2022 Background Compelling evidence suggests that the fbroblast growth factor 23 (FGF23) / α-klotho axis is impaired in subjects with diabetes mellitus. We examined the relationship between parameters related to calcium/phosphate homeostasis, including FGF23 ...
Alonso Pedrol, Núria +11 more
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BMC Public Health, 2023 Background Klotho is a hormone considered to be an anti-aging biomarker. The relationships between daily alcohol consumption and serum klotho are mainly unknown.
Meihua Jiang +4 more
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Positioning novel biologicals in CKD-mineral and bone disorders [PDF]
, 2017 Renal osteodystrophy (ROD), the histologic bone lesions of chronic kidney disease (CKD), is now included in a wider syndrome with laboratory abnormalities of mineral metabolism and extra-skeletal calcifications or CKD-mineral and bone disorders (CKD-MBD),
Covic, Adrian +5 more
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Klotho controls the brain-immune system interface in the choroid plexus. [PDF]
, 2018 Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood.
Ho, Kaitlyn +7 more
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Neuropsychiatric Systemic Lupus Erythematosus Involvement: Towards a Tailored Approach to Our Patients? [PDF]
, 2017 Neuropsychiatric involvement in systemic lupus erythematosus (NPSLE) is a complex condition that remains poorly understood, and includes heterogeneous manifestations involving both the central and peripheral nervous system, with disabling effects.
Dias, R., Faria, R., Gonçalves, J.
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