Results 21 to 30 of about 7,898 (167)

Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium

Cell Death and Disease, 2023
Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming growth factor-β2 (TGF-β2) and oxidative stress play a critical role in the progression of age-related macular degeneration (AMD).
Ha Young Jang, Soo-Jin Kim, Kyu-Sang Park, Jeong Hun Kim   +3 more
doaj   +1 more source

Association between serum cotinine and α-Klotho levels among adults: Findings from the National Health and Nutrition Examination Survey 2007–2016

Tobacco Induced Diseases, 2022
Introduction Serum cotinine is a sensitive and specific marker of tobacco smoke exposure. α-Klotho is an anti-ageing molecule, which plays an important role in several diseases.
Yu Yao, Ying Long, Fa-Wang Du, Yong Zhao, Xiao-Bin Luo   +4 more
doaj   +1 more source

GWAS META-analysis followed by MENDELIAN randomisation revealed potential control mechanisms for circulating α-klotho levels [PDF]

, 2021
The protein α-Klotho acts as transmembrane co-receptor for fibroblast growth factor 23 (FGF23) and is a key regulator of phosphate homeostasis. However, α-Klotho also exists in a circulating form, with pleiotropic, but incompletely understood functions ...
Andlauer, Till F.M., Brandenburg, Vincent, Davey Smith, George, Falk, Louise, Gergei, Ingrid, Krämer, Bernhard K., Mirza-Schreiber, Nazanin, Moverare-Skrtic, Sofia, März, Winfried, Müller-Myhsok, Bertram, Ohlsson, Claes, Richard, Daniel, Tobias, Jonathan H, Voelkl, Jakob, Zheng, Jie   +14 more
core   +7 more sources

Association between perfluoroalkyl and polyfluoroalkyl internal exposure and serum α-Klotho levels in middle-old aged participants

Frontiers in Public Health, 2023
PurposeExposure to perfluoroalkyl and polyfluoroalkyl substances causes oxidative stress, which is strongly associated with adverse health effects. Klotho protein plays an anti-aging role via antioxidation activity.MethodsWe investigated the levels of ...
Min Li, Min Li, Yuanlin Ma, Wenli Cheng, Luyun Zhang, Cheng Zhou, Wenji Zhang, Wenjuan Zhang   +7 more
doaj   +1 more source

Serum α-Klotho associated with oral health among a nationally representative sample of US adults

Frontiers in Endocrinology, 2022
BackgroundLow klotho is associated with aging-related traits. However, no study has assessed the association between klotho and oral health in a large sample of population.
Guo-Qiang Chen, Guo-Qiang Chen, Yao Duan, Jin-Feng Wang, Ying Lian, Xiu-Li Yin   +5 more
doaj   +1 more source

FGF23-klotho axis as predictive factors of fractures in type 2 diabetics with early chronic kidney disease [PDF]

, 2020
Background: The aim of our study was to evaluate the relevance of FGF23-klotho axis in the predisposition for bone fractures in type 2 diabetic patients with early chronic kidney disease.
Ana Luísa Ribeiro, Ana Paula Silva, Bacchetta, Bernheim, Block, Daya, Desjardins, Ducy, Ducy, Eduarda Carias, Ferron, Filipa Mendes, Fliser, Fátima Rato, Gutiérrez, Hill, Hu, Isakova, Isakova, Jovanovich, Kazama, Lane, Lee, Levey, Manghat, Mirza, Mirza, Moayeri, Moreno, Moseley, Nélio Santos, Pedro Leão Neves, Pi, Pinkau, Qu, Quarles, Ray, Sanches, Sellmeyer, Shimada, Silva, Silva, Silva, Sitara, Stubbs, Titan, Torres, Urakawa, Wallace, Wang, Wolf, Yilmaz, Zimering   +52 more
core   +1 more source

Gla-rich protein (GRP) as an early and novel marker of vascular calcification and kidney dysfunction in diabetic patients with CKD: a pilot cross-sectional study [PDF]

, 2020
Vascular calcification (VC) is one of the strongest predictors of cardiovascular risk in chronic kidney disease (CKD) patients. New diagnostic/prognostic tools are required for early detection of VC allowing interventional strategies.
Almeida, Edgar de, Dias, Carolina, Faísca, Marília, Guilherme, Patrícia, Macedo, Ana, Mendes, Filipa, Neves, Pedro Leão, Rato, Fátima, Santos, Nélio, Silva, Ana P., Simes, Dina, Tavares, Nelson, Viegas, Carla   +12 more
core   +1 more source

Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantation [PDF]

, 2017
Relationships of Sclerostin, a bone anti-anabolic protein, with biomarkers of mineral bone disorders in chronic kidney disease are still unsettled, in particular in kidney transplant (KTR).
Farcomeni, Alessio, Fassino, Valeria, Leonangeli, Cristiana, Mazzaferro, Sandro, Muci, MARIA LUISA, Pasquali, Marzia, Rotondi, Silverio, Tartaglione, Lida   +7 more
core   +8 more sources

Research Models for Studying Vascular Calcification [PDF]

, 2020
Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process.
Babic, Milen, Giet, Markus van der, Herrmann, Jaqueline, Schuchardt, Mirjam, Tölle, Markus   +4 more
core   +1 more source

The relevance of α-KLOTHO to the central nervous system: Some key questions [PDF]

, 2017
α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum.
Berwick, Daniel Charles, Cararo-Lopes, Marina Minto, Kawamoto, Elisa Mitiko, Mazucanti, Caio Henrique Yokoyama, Scavone, Cristoforo   +4 more
core   +1 more source