Results 21 to 30 of about 741,770 (157)

Association of α-klotho concentrations with cardiovascular and all-cause mortality in American adults with depression: a national prospective cohort study [PDF]

Translational Psychiatry
This study examines α-klotho levels in depressed American adults and their association with cardiovascular disease and all-cause mortality, utilizing data from the National Health and Nutrition Examination Survey (2007–2016) and mortality details from ...
Jiayu Zhao, Tong Zhou, Yang Jing, Jiarui Shao, Cailin Xie, Yingying Huang, Tian Long, Jiaming Luo   +7 more
doaj   +2 more sources

Current marijuana use is associated with lower circulating α-Klotho levels in US adults even after adjusting for tobacco use: A national cross-sectional analysis of NHANES [PDF]

Tobacco Induced Diseases
Introduction α-Klotho is a circulating protein linked to longevity and healthy aging. While tobacco use is known to reduce α-Klotho levels, the effects of marijuana use on this aging-related biomarker remain unclear.
Kai Wei, Xiaotong Chen
doaj   +2 more sources

Advanced maternal age causes premature placental senescence and malformation via dysregulated α‐Klotho expression in trophoblasts [PDF]

, 2021
Advanced maternal age (AMA) pregnancy is associated with higher risks of adverse perinatal outcomes, which may result from premature senescence of the placenta.
Hongbo Qi, Xin Li, Huijia Fu, Philip N. Baker, Wen, Li, Mark D. Kilby, Li, Xin, Qi, Hongbo, Chen, Zhi, Huili Jin, Zhi Chen, Xiong, Liling, Liling Xiong, Chao Tong, Yu, Jiaxiao, Kilby, Mark D., Saffery, Richard, Richard Saffery, Li Wen, Jiaxiao Yu, Tong, Chao, Fu, Huijia, Baker, Philip N., Jin, Huili   +23 more
core   +2 more sources

Reduced Plasma Levels of α-Klotho and Their Correlation With Klotho Polymorphisms in Elderly Patients With Major Depressive Disorders

Frontiers in Psychiatry, 2021
Background: Recent literature suggests that α-Klotho, a widely recognized anti-aging protein, is involved in longevity as well as in many diseases, including Alzheimer's disease, and depression.
Xiang Gao, Zuoli Sun, Guangwei Ma, Yuhong Li, Min Liu, Guofu Zhang, Hong Xu, Yane Gao, Jixuan Zhou, Qi Deng, Rena Li, Rena Li   +11 more
doaj   +1 more source

Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice

Molecular Metabolism, 2021
Objective: Our laboratory recently identified the centrally circulating α-klotho protein as a novel hypothalamic regulator of food intake and glucose metabolism in mice. The current study aimed to investigate novel molecular effectors of central α-klotho
Taylor Landry, Peixin Li, Daniel Shookster, Zhiying Jiang, Hongli Li, Brenton Thomas Laing, Wyatt Bunner, Theodore Langton, Qingchun Tong, Hu Huang   +9 more
doaj   +1 more source

The Role of Soluble α-klotho Protein in Acromegaly [PDF]

, 2023
Soluble α-klotho (sαKl) is an isoform of the α-klotho protein that regulates calcium metabolism but also has anti-aging, anti-apoptotic, and tumor suppressor effects.
Carmen Emanuela GEORGESCU, Oana PINZARIU
core   +1 more source

Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium

Cell Death and Disease, 2023
Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming growth factor-β2 (TGF-β2) and oxidative stress play a critical role in the progression of age-related macular degeneration (AMD).
Ha Young Jang, Soo-Jin Kim, Kyu-Sang Park, Jeong Hun Kim   +3 more
doaj   +1 more source

Association between serum cotinine and α-Klotho levels among adults: Findings from the National Health and Nutrition Examination Survey 2007–2016

Tobacco Induced Diseases, 2022
Introduction Serum cotinine is a sensitive and specific marker of tobacco smoke exposure. α-Klotho is an anti-ageing molecule, which plays an important role in several diseases.
Yu Yao, Ying Long, Fa-Wang Du, Yong Zhao, Xiao-Bin Luo   +4 more
doaj   +1 more source

Serum α-Klotho associated with oral health among a nationally representative sample of US adults

Frontiers in Endocrinology, 2022
BackgroundLow klotho is associated with aging-related traits. However, no study has assessed the association between klotho and oral health in a large sample of population.
Guo-Qiang Chen, Guo-Qiang Chen, Yao Duan, Jin-Feng Wang, Ying Lian, Xiu-Li Yin   +5 more
doaj   +1 more source

Data_Sheet_1_Reduced Plasma Levels of α-Klotho and Their Correlation With Klotho Polymorphisms in Elderly Patients With Major Depressive Disorders.docx

, 2021
Background: Recent literature suggests that α-Klotho, a widely recognized anti-aging protein, is involved in longevity as well as in many diseases, including Alzheimer's disease, and depression.
Yuhong Li (448146), Guofu Zhang (463042), Guangwei Ma (8503014), Hong Xu (71477), Xiang Gao (4077), Zuoli Sun (10077130), Qi Deng (314917), Min Liu (45756), Rena Li (284970), Yane Gao (11556388), Jixuan Zhou (11556391)   +10 more
core   +1 more source