Results 51 to 60 of about 17,091 (230)

Effects of klotho protein or klotho knockdown in porcine oocytes at different stages

Zygote, 2023
SummaryKlotho is a protein that plays different functions in female fertility. We have previously reported that klotho protein supplementation during in vitro maturation improves porcine embryo development, while klotho knockout for somatic cell cloning completely blocks full-term pregnancy in vivo.
Eun Pyo Kim, Do Yon Kim, Changhoon Park, Seung-Min Yoo, Myung-Shin Lee, Geon A Kim   +5 more
openaire   +2 more sources

Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice

Frontiers in Cellular Neuroscience, 2019
The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular ...
Dongxue Li, Dongqing Jing, Ziyang Liu, Ying Chen, Fang Huang, Thomas Behnisch   +5 more
doaj   +1 more source

Central a-Klotho is a Novel Regulator of Arcuate Neurons and Peripheral Metabolism

, 2023
The arcuate nucleus of the hypothalamus (ARC) is a critical nexus of neuron populations that interpret peripheral signals of energy status and deliver diverse efferent outputs to metabolically active tissues.
NC DOCKS at East Carolina University, Landry, Taylor   +1 more
core  

Klotho—open questions, controversies, and future perspectives

, 2021
Klotho acts as an obligate FGF23 coreceptor and is as such integral to FGF23 physiology. Membrane-bound Klotho is primarily expressed in the kidney tubular epithelium, from where soluble Klotho protein is released into circulation.
Mencke, Rik, Rik Mencke, Olauson, Hannes, Hannes Olauson   +3 more
core   +1 more source

Overexpression of klotho suppresses growth and pulmonary metastasis of osteosarcoma in vivo

Genetics and Molecular Biology
Klotho is originally discovered as an anti-aging gene and knock-out of klotho accelerates aging in mice. Subsequent studies support the anti-carcinogenesis role of klotho in a variety of human malignancies.
Ying Li, Hai-jun Xiao, Feng Xue
doaj   +1 more source

Upregulation of the Creatine Transporter Slc6A8 by Klotho

Kidney & Blood Pressure Research, 2014
Background/Aims: The transmembrane Klotho protein contributes to inhibition of 1,25(OH)2D3 formation. The extracellular domain of Klotho protein could function as an enzyme with e.g. β-glucuronidase activity, be cleaved off and be released into blood and
Ahmad Almilaji, Mentor Sopjani, Bernat Elvira, José Borras, Miribane Dërmaku-Sopjani, Carlos Munoz, Jamshed Warsi, Undine E. Lang, Florian Lang   +8 more
doaj   +1 more source

Failure to maintain full-term pregnancies in pig carrying klotho monoallelic knockout fetuses

BMC Biotechnology, 2021
Background Small animals that show a deficiency in klotho exhibit extremely shortened life span with multiple aging-like phenotypes. However, limited information is available on the function of klotho in large animals such as pigs.
Sanghoon Lee, Min Hee Jung, Kilyoung Song, Jun-Xue Jin, Anukul Taweechaipaisankul, Geon A. Kim, Hyun Ju Oh, Ok Jae Koo, Se Chang Park, Byeong Chun Lee   +9 more
doaj   +1 more source

Serum α-Klotho associated with oral health among a nationally representative sample of US adults

Frontiers in Endocrinology, 2022
BackgroundLow klotho is associated with aging-related traits. However, no study has assessed the association between klotho and oral health in a large sample of population.
Guo-Qiang Chen, Guo-Qiang Chen, Yao Duan, Jin-Feng Wang, Ying Lian, Xiu-Li Yin   +5 more
doaj   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease

BMC Nephrology, 2012
Background Klotho is a single-pass transmembrane protein, which appears to be implicated in aging. The purpose of the present study was to characterize the relationship between the soluble Klotho level and renal function in patients with various degrees ...
Akimoto Tetsu, Yoshizawa Hiromichi, Watanabe Yuko, Numata Akihiko, Yamazaki Tomoyuki, Takeshima Eri, Iwazu Kana, Komada Takanori, Otani Naoko, Morishita Yoshiyuki, Ito Chiharu, Shiizaki Kazuhiro, Ando Yasuhiro, Muto Shigeaki, Kuro-o Makoto, Kusano Eiji   +15 more
doaj   +1 more source