Results 81 to 90 of about 11,920 (192)

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, Volume 13, Issue 26, 8 May 2026.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Fibroblast growth factor 10 attenuates advanced liver fibrosis through hepatocyte fibroblast growth factor receptor 2 signalling

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
FGF10‐FGFR2 signaling is progressively impaired during liver fibrosis. FGF10 restoration protects hepatocytes from inflammatory and apoptotic injury. Hepatocyte FGFR2 mediates FGF10‐driven suppression of fibrogenic remodeling through the GSK3β/NF‐κB axis.
Xuanxin Yang, Qingqing Dong, Jiaying Ma, Yawei Yan, Shuangyan Peng, Qiqi Wu, Huan Wang, Tingting Zhang, Panyu Zhang, Zelong Jiang, Chao Lu, Le Li, Xinyi You, Yuandong Xu, Joshua Banda, Zhixiang Mu, Minghua Zheng, Xiaokun Li, Qi Hui, Bingjie Yu, Xiaojie Wang   +20 more
wiley   +1 more source

Intersecting Molecular Pathways in Cardiovascular Disease and Diabetes Mellitus: Emerging Roles of Inflammation and Therapeutics

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 4, May 2026.
Central illustration: Pathophysiological mechanisms linking diabetes mellitus and cardiovascular disease. Chronic hyperglycaemia, insulin resistance, and low‐grade inflammation contribute to endothelial dysfunction, myocardial fibrosis, and cardiomyocyte apoptosis.
Lilian Anagnostopoulou, Nikolaos Ktenopoulos, Anastasios Apostolos, Christos Fragoulis, Panayotis Vlachakis, Paschalis Karakasis, Marios Sagris, Nikias Milaras, Maria Drakopoulou, Andreas Synetos, Ioannis Kyriazis, Ioannis Ioannidis, Costas Tsioufis, Konstantinos Toutouzas   +13 more
wiley   +1 more source

Nutritional Interventions and Acupuncture‐Based Strategies for Exercise‐Induced Fatigue and Recovery: Mechanisms and Integrative Perspectives

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Excessive exercise induces exercise‐induced fatigue through multiple interconnected mechanisms, including energy shortage and metabolite accumulation, oxidative stress and inflammation, mitochondrial dysfunction, and neuroendocrine strain. Integrative management strategies include nutrition‐based approaches and acupuncture‐based interventions ...
Yaqin Yang, Yao Yao, Weiyu Lu, Jiazhou Li, Lijuan Zou, Huashan Pan   +5 more
wiley   +1 more source

Diagnostic and Therapeutic Roles of Extracellular Vesicles in Chronic Kidney Disease: A Systematic Review

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
This systematic review compiles and analyses 364 studies on chronic kidney disease (CKD) that investigated extracellular vesicles (EVs) for diagnostic and therapeutic applications. By systematically categorizing data according to EV source and cargo, it provides an integrated overview of EV application for CKD, highlighting common approaches and shared
Tunahan Ergunay, Alessia Brossa, Benedetta Bussolati   +2 more
wiley   +1 more source

Klotho sensitivity of the hERG channel

FEBS Letters, 2013
Klotho, a hormone and enzyme, is a powerful regulator of ageing and life span. Klotho deficiency leads to cardiac arrythmia and sudden cardiac death. We thus explored whether klotho modifies cardiac K+‐channel hERG. Current was determined utilizing dual electrode voltage clamp and hERG protein abundance utilizing immunohistochemistry and ...
Munoz, Carlos, Pakladok, Tatsiana, Almilaji, Ahmad, Elvira, Bernat, Seebohm, Guiscard, Voelkl, Jakob, Föller, Michael, Shumilina, Ekaterina, Lang, Florian   +8 more
openaire   +3 more sources

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

Klotho Mice [PDF]

, 2014
BackgroundAs the elderly population continues to expand, it becomes increasingly important to develop treatments to improve wound healing in the elderly. One problem limiting the research is the lack of appropriate animal models for wound healing in elderly patients. We hypothesized that the Klotho mouse of premature aging is a suitable animal model to
Yamashita, Ken, Yotsuyanagi, Takatoshi, Yamauchi, Makoto, Young, David M   +3 more
openaire   +1 more source

Recombinant α-Klotho Protein Alleviated Acute Cardiorenal Injury in a Mouse Model of Lipopolysaccharide-Induced Septic Cardiorenal Syndrome Type 5

Analytical Cellular Pathology, 2019
Background and Aims. Klotho is an aging-suppressor gene mainly expressed in the renal tubules. The klotho gene encodes the α-klotho protein, which has many functions. Previous studies have found that α-klotho protein has a cardiorenal protective function.
Xi Liu, Yangyang Niu, Xiaoqin Zhang, Yingying Zhang, Ying Yu, Jieli Huang, Jiangtao Li, Chen Yu   +7 more
doaj   +1 more source

Adipose Tissue‐Targeted Delivery of Rosiglitazone With Iron Oxide Nanoparticles Ameliorates Insulin Resistance in Male Mice

Obesity, Volume 34, Issue 5, Page 1068-1080, May 2026.
ABSTRACT Objective This study aimed to assess iron oxide magnetic nanoparticles (MNPs) for adipose tissue‐targeted therapeutics to restore adipose tissue function and insulin sensitivity in obesity. Methods The insulin‐sensitizing effects of rosiglitazone and known adverse effects were leveraged for this proof‐of‐concept assessment of adipose tissue ...
Jakob E. Ostberg, Zeeshan Ahmed, Katayoun Saatchi, Parleen K. Pandher, Yamna Rahim, Urs O. Häfeli, Sarah L. Gray   +6 more
wiley   +1 more source