Results 81 to 90 of about 17,091 (230)

Urinary Incontinence and Risk of All‐Cause Mortality: A Systematic Review and Meta‐Analysis of Observational Studies

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims Urinary incontinence (UI) is a prevalent condition among adults and imposes a substantial societal burden, yet its association with all‐cause mortality remains uncertain. This study systematically reviewed and quantified the association between UI and mortality risk.
Yanyan Zhou, Liwei Wang, Weijia Sun, Zhong Wang, Kuiqing Shao, Feng Xu, Zhan Gao   +6 more
wiley   +1 more source

Hyperaldosteronism in Klotho-deficient mice

, 2010
Klotho is a membrane protein participating in the inhibitory effect of FGF23 on the formation of 1,25-dihydroxyvitamin-D3 [1,25(OH)2D3]. It participates in the regulation of renal tubular phosphate reabsorption and stimulates renal tubular Ca2 ...
Rexhepaj, Rexhep, Makoto Kuro-o, Rexhep Rexhepaj, Hocher, Berthold (Prof.), Balasaheb Siraskar, Leibrock, Christina B., Boini, Krishna M., Daniela S. Kempe, Lang, Florian, Foeller, Michael, Krishna M. Boini, Michael Föller, Kuro-o, Makoto, Kevin P. Rosenblatt, Stephanie S. Fischer, Florian Lang, Ackermann, Teresa F., Berthold Hocher, Kempe, Daniela S., Fischer, Stephanie S., Teresa F. Ackermann, Siraskar, Balasaheb, Rosenblatt, Kevin P., Christina B. Leibrock   +23 more
core   +1 more source

Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells

Physiological Reports, 2021
Chronic kidney disease (CKD) has a high prevalence worldwide and is an intricate issue to whole medical society. Renal fibrosis is the common pathological feature for various kinds of CKD.
Jinhua Miao, Jiewu Huang, Congwei Luo, Huiyun Ye, Xian Ling, Qinyu Wu, Weiwei Shen, Lili Zhou   +7 more
doaj   +1 more source

Hypophosphataemia in adults: approach to diagnosis and management

Internal Medicine Journal, EarlyView.
Abstract Hypophosphataemia is a common electrolyte disorder which can have clinically significant consequences for bone, muscle, neurological and haematological function. Its causes range from transient transcellular shifts in hospitalised patients to chronic renal phosphate‐wasting disorders mediated by fibroblast growth factor 23 (FGF23).
Kajanan Parameshwaran, Mawson Wang, Kirtan Ganda   +2 more
wiley   +1 more source

Reduced Serum Levels of Klotho are Associated with Mild Cognitive Impairment in Patients with Type 2 Diabetes Mellitus

, 2023
Haina Zhang,1 Lou Yu,2 Gai Yun3 1Department of General Medicine, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, 201399, People’s Republic of China; 2Department of Preventive Treatment, Shanghai Seventh People’s ...
Yu L, Yun G, Zhang H
core  

Klotho sensitivity of the hERG channel [PDF]

, 2013
Klotho, a hormone and enzyme, is a powerful regulator of ageing and life span. Klotho deficiency leads to cardiac arrythmia and sudden cardiac death. We thus explored whether klotho modifies cardiac K+-channel hERG.
Elvira, Bernat, Föller, Michael, Pakladok, Tatsiana, Almilaji, Ahmad, Voelkl, Jakob, Völkl, Jakob Georg Jonathan, Lang, Florian, Seebohm, Guiscard, Shumilina, Ekaterina, Munoz, Carlos, Muñoz Hernando, Carlos   +10 more
core   +1 more source

Data_Sheet_1_Reduced Plasma Levels of α-Klotho and Their Correlation With Klotho Polymorphisms in Elderly Patients With Major Depressive Disorders.docx

, 2021
Background: Recent literature suggests that α-Klotho, a widely recognized anti-aging protein, is involved in longevity as well as in many diseases, including Alzheimer's disease, and depression.
Yuhong Li (448146), Guofu Zhang (463042), Guangwei Ma (8503014), Hong Xu (71477), Xiang Gao (4077), Zuoli Sun (10077130), Qi Deng (314917), Min Liu (45756), Rena Li (284970), Yane Gao (11556388), Jixuan Zhou (11556391)   +10 more
core   +1 more source

Klotho Enhances Postnatal Skeletal Muscle Growth [PDF]

, 2015
Klotho is a pleiotrophic gene that regulates homeostasis in various tissues. Although Klotho function has been typically viewed in the context of an "anti-aging" molecule, we have observed that its expression in muscle decreases during postnatal muscle ...
Lindsay, Catherine Claire
core   +1 more source

Reduced Circulating α‐Klotho Levels Are Associated With Elevated Mortality and Arterial Calcifications of Aorta and Iliac Arteries

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background α‐Klotho is a multifunctional protein implicated in vascular aging. Declining Klotho levels are associated with arterial stiffness, endothelial dysfunction, and vascular calcification.
Elias Hellou, Parvin Kalhor, Ali Babaie, Nadia Akhiyat, Negin Mahmoudi Hamidabad, Valentina Nardi, Matteo Manzato, Kai Nogami, Elizabeth Copley, Lilach O Lerman, Amir Lerman   +10 more
doaj   +1 more source

Effect of Two Therapeutic Renal Diets on Hormonal and Regulatory Pathways Affecting Calcium Homeostasis in Cats With Early‐Stage Chronic Kidney Disease

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Chronic kidney disease (CKD) is a known risk factor for hypercalcemia in cats. Phosphate‐restricted diets have also been implicated in causing hypercalcemia, in part because phosphate restriction increases the Ca:P ratio. The primary objective of this study was to evaluate the impact of two different therapeutic renal foods on ionized (iCa ...
Jean A. Hall, Elizabeth M. Morris, Dale A. Fritsch, John J. Brejda, Kim M. Wilson   +4 more
wiley   +1 more source