Results 101 to 110 of about 17,091 (230)

Seven days of warm‐water immersion enhances resting irisin and BDNF, but not klotho, in older men

Experimental Physiology, EarlyView.
Abstract We examined whether seven consecutive days of warm‐water immersion could elevate resting and exercise‐induced levels of brain‐derived neurotrophic factor (BDNF), irisin and klotho in older adults. These biomarkers support cognitive and metabolic health, but their levels decline with age.
Joel M Garrett, James J McCormick, Kelli E King, Kristina‐Marie T Janetos, Nathalie V Kirby, Fergus K O'Connor, Glen P Kenny   +6 more
wiley   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Inflammation-Induced Klotho Deficiency: A Possible Key Driver of Chronic Kidney Disease Progression [PDF]

Yan Liang,1 Qi Zhang,1 Jing-Rong Qian,2 Sha-Sha Li,3 Qi-Feng Liu1,2 1Gusu School, Nanjing Medical University, The First People’s Hospital of Kunshan, Kunshan, Jiangsu, 215300, People’s Republic of China; 2Department of Nephrology, Affiliated Kunshan ...
Liu QF, Liang Y, Qian JR, Li SS, Zhang Q
core  

Structure and functions of Klotho protein [PDF]

, 2012
Klotho gene was identified in 1997, and named after a Greek goddess Klotho, who spun the thread of life. The inactivation of Klotho gene in mice leads to a syndrome resembling aging, whereas the overexpression of Klotho extends their life span.
Szymczak, Agnieszka, Forma, Ewa
core  

Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane [PDF]

, 2004
Klotho mutant mice exhibit a set of phenotypes resembling human ageing. Although the function of Klotho remains unclear, mediation of its pleiotropic functions by putative humoral factor(s) has been presumed.
Hashimoto, Nobuo, Fujimori, Toshihiko, Akiko Iwano, Toshihiko Fujimori, Nabeshima, Yo-Ichi, Osamu Tohyama, Iwano, Akiko, Yoshihito Tsuji, Nobuo Hashimoto, Tohyama, Osamu, Imura, Akihiro, Yo-Ichi Nabeshima, Akihiro Imura, Nozaki, Kazuhiko, Tsuji, Yoshihito, Kazuhiko Nozaki   +15 more
core   +1 more source

Mechanisms of Exercise Training in Ameliorating Cognitive Function in Patients With Depression: A Narrative Review of Molecular Targets and Clinical Prescriptions

European Journal of Sport Science, Volume 26, Issue 11, November 2026.
ABSTRACT Depression is frequently accompanied by core cognitive impairments, notably in executive function and memory. Although the ameliorative effects of exercise training have been widely corroborated, the evidence regarding its underlying mechanisms remains fragmented. To provide a comprehensive and integrated view, this review proposes a testable,
Zhaohui Guo, Lingling Dong, Jessie J. X. Lin, Yanping Duan, Weizhi Liu, Wanting Jiang, Cong Liu, Shuqi Jia, Yagang Song, Feng Ding, Zhenwen Xie, Mingyue Yin, Kang Zhu, Xiaochen Ma, Peng Wang, Chen Wei, Felipe Barreto Schuch, Xing Wang   +17 more
wiley   +1 more source

Recombinant α-Klotho Protein Alleviated Acute Cardiorenal Injury in a Mouse Model of Lipopolysaccharide-Induced Septic Cardiorenal Syndrome Type 5

Analytical Cellular Pathology, 2019
Background and Aims. Klotho is an aging-suppressor gene mainly expressed in the renal tubules. The klotho gene encodes the α-klotho protein, which has many functions. Previous studies have found that α-klotho protein has a cardiorenal protective function.
Xi Liu, Yangyang Niu, Xiaoqin Zhang, Yingying Zhang, Ying Yu, Jieli Huang, Jiangtao Li, Chen Yu   +7 more
doaj   +1 more source

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source

Klotho Exerts an Emerging Role in Cytokinesis

, 2020
The Klotho gene functions as an anti-aging gene. A previous klotho-knockout mice study indicated that neither male nor female gametocytes could accomplish the first meiotic division. It suggested that Klotho might regulate cell division.
Chiao-Yin Sun, Kang-Chieh Lo, Yan-Liang Liou, Chi-Yuan Chou, Yu-Ying Hsieh, Yau-Hung Chen   +5 more
core   +1 more source

α-Klotho Expression in Human Tissues. [PDF]

, 2015
CONTEXT: α-Klotho has emerged as a powerful regulator of the aging process. To date, the expression profile of α-Klotho in human tissues is unknown, and its existence in some human tissue types is subject to much controversy. OBJECTIVE: This is the first

core   +2 more sources