Results 111 to 120 of about 17,091 (230)

α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid

Frontiers in Aging Neuroscience
IntroductionCSF α-klotho levels might affect Aβ40, Aβ42, and the Aβ42/40 ratio in the cerebrospinal fluid (CSF).MethodsCSF α-klotho was assayed in ovariectomized rhesus macaques (NHPs) maintained on a Western-style diet (WSD) to assess the effect of ...
Jacob Raber, Jacob Raber, Jacob Raber, Jacob Raber, Alexandra Pederson, Emily Bunnell, Nora Mattek, Nora E. Gray, Steven G. Kohama, Alison R. Weiss, Alison R. Weiss, Alison R. Weiss, Joseph F. Quinn, Henryk F. Urbanski, Henryk F. Urbanski, Henryk F. Urbanski   +15 more
doaj   +1 more source

Review Article: Fibrosis Reversal in Metabolic Dysfunction‐Associated Steatohepatitis—The Promise of Emerging Therapeutics

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 9, Page 1184-1196, November 2026.
Metabolic dysfunction‐associated steatohepatitis is the second commonest US indication for liver transplantation but remains largely undiagnosed and untreated. Fibrosis stage is the strongest predictor of major adverse liver outcomes, with decompensation rates and transplant‐free survival diverging sharply between F3 and F4, while cardiovascular ...
Malek Ayoub, Tsubasa Tsutsumi, Mary E. Rinella   +2 more
wiley   +1 more source

Renal Klotho in mineral metabolism

, 2014
Calcium and phosphorous are critical elements in a number of physiological processes, including maintenance of bone structure, cell signaling and energy metabolism.
Risul Amin (18665890)
core   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, Volume 30, Issue 5, Page 627-640, October 2026.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Gallstone formation and hepatobiliary tumour risk: Clinical implications of the bile acid–gut microbiota axis

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Irregular dietary patterns (e.g., late breakfast, reduced meal frequency) upregulate the bai gene cluster by disrupting cholecystokinin (CCK) release rhythms and gut microbiota circadian rhythms, leading to increased production of secondary bile acids, particularly DCA. High‐carbohydrate dietary patterns increase gallstone risk (OR = 1.329).
Rui Li, Yong Zhang, Kaishuang Cai, Shaojun Deng, Chaofeng Tan, Yunjie Li, Wenjin Liang   +6 more
wiley   +1 more source

Gender-specific association between circulating serum Klotho and metabolic components in adults

BMC Endocrine Disorders
Background Klotho plays a pivotal role in human aging. Metabolic syndrome (MetS) is composed of multiple conditions that are also risk factors for cardiovascular disease and diabetes.
Zhenzhen Wang, Hang Zhang, Guixia Zheng, Zheng Wang, Lei Shi   +4 more
doaj   +1 more source

Acute Effects of Brief Exercise on Alcohol Craving Among Young Adults With Problematic Alcohol Use: A Systematic Review

European Journal of Sport Science, Volume 26, Issue 10, October 2026.
ABSTRACT Alcohol craving is a key process in alcohol abuse, especially during young adulthood, a period of heightened vulnerability and continued brain development. Although acute physical exercise has been proposed as a potential strategy to reduce craving and modulate affective and cognitive processes, current evidence remains limited regarding its ...
P. Sampedro‐Piquero, A. Cordellat‐Marzal, M. Dragotti, L. Mandolesi, O. Gigliotta, R. D. Moreno‐Fernández   +5 more
wiley   +1 more source

The Role Of Klotho In Adult Neurogenesis [PDF]

, 2017
Klotho is an anti-aging protein that when upregulated, extends lifespan and enhances cognition. Klotho knockout mice age prematurely and die by ~8 weeks of life after developing cognitive impairment.
Laszczyk, Ann
core  

Klotho gene and endothelial function

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2006
The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes (e.g. arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, skin atrophy). We have demonstrated that mice deficient for the klotho gene show endothelial dysfunction as manifested by an attenuated response of aortic relaxation in ...
Saito, Yuichiro, Kurabayashi, Masahiko, Nakamura, Tetsuya, Nagai, Ryozo   +3 more
openaire   +3 more sources

Role of Triceps Muscle Fiber‐Specific Myokines in Pancreatic β‐Cell Protection: Implications for Type 2 Diabetes: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Type 2 diabetes (T2D) is a major global health challenge, primarily driven by insulin resistance and progressive β‐cell dysfunction aggravated by chronic low‐grade inflammation. Skeletal muscle has emerged as a pivotal endocrine organ through the secretion of myokines, which exert systemic metabolic and immunomodulatory ...
Christian Tague, Dujardin Makeda, Hermann Yokolo, Joshua Ekouo   +3 more
wiley   +1 more source