Results 131 to 140 of about 17,091 (230)

Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Aging is a systemic decline in physiological integrity, driving chronic diseases such as neurodegeneration, cardiovascular disorders, and metabolic syndromes. Rapid global population aging urgently demands effective interventions. Traditional Chinese medicine (TCM) formulas, characterized by multi‐component, multi‐target, and multi‐pathway ...
Chenrong Jin, Ding Du, Xiaorui Yu, Xiaoyan Ji, Xiuyun Zhang, Anning Li, Shuang Zu, Bo Qu, Daqing Zhao, Dianpeng Wu, Meichen Liu   +10 more
wiley   +1 more source

Fenofibrate Protects Against Antipsychotic‐Induced Hyperglycemia Through Weight Loss and FGF21 Dependent Mechanisms

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
The proposed mechanism through which fenofibrate protects against olanzapine‐induced hyperglycemia in mice. ABSTRACT Antipsychotic (AP) medications, such as olanzapine, cause acute weight gain independent of hyperglycemia through a glucagon‐dependent mechanism.
Michael Akcan, Stewart Jeromson, Bradley J. Baranowski, Annalaura Bellucci, Serena Trang, Katelyn Eisner, Ailish Babicki‐Moore, Hadil Alfares, Meagan Arbeau, Kyle Medak, Margaret Hahn, David C. Wright   +11 more
wiley   +1 more source

The effects of Klotho delivering mesenchymal stem cell-derived small extracellular vesicles on acute kidney injury

Journal of Nanobiotechnology
Acute kidney injury (AKI) is a life-threating syndrome characterized by sudden loss of kidney function, and its management is challenging and often suboptimal.
Xiao-Hui Deng, Zi-Cong Wu, Qi Sun, Long-Xin Huang, Ying-Chun Xie, Dong-Xiao Lou, Chan-Gu Li, Xiao-Qing Liu, Zhi-Rou Zhou, Tian Tian, Chang-Lin Lian, Qing-Ling Fu   +11 more
doaj   +1 more source

Klotho and The Kidney

Klotho has emerged as one of the most important renoprotective proteins linking kidney function with systemic metabolic, endocrine, and cardiovascular health.
Neha Sharma, Sanjay Kalra, Sourabh Sharma   +2 more
core   +1 more source

P2X7 receptors and klotho [PDF]

Purinergic Signalling, 2020
openaire   +2 more sources

Decreased Klotho expression inhibits VEGFR2/PAK1 signaling.

, 2013
(A) Flow cytometry analysis for VEGFR2 expression in BEL7402 cells stably transfected with nonspecific shRNA, and Klotho 1# shRNA, respectively. (B) Western blot analysis of PAK1, Klotho and GAPDH protein levels and (C) immunofluorescence staining of ...
Deng Pan (47215), Haiou Liu (389061), Qian Wu (209382), Le Xu (102322), Jiejie Xu (389064), Heng Zhang (320479), Yu Zhu (250261), Weisi Liu (389063), Shifang Ren (335763), Jing Liu (38537), Hongyong He (389062), Lin Chen (54305), Jianxin Gu (335766), Yidong Liu (155545), Shanshan Wang (283009)   +14 more
core   +1 more source

Klotho-mediated activation of the anti-oxidant Nrf2/ARE signal pathway affects cell apoptosis, senescence and mobility in hypoxic human trophoblasts: involvement of Klotho in the pathogenesis of preeclampsia

Cell Division
The anti-aging gene Klotho is implicated in the pathogenesis of preeclampsia (PE), which is a pregnancy disease characterized by hypertension and proteinuria.
Baomei Xu, Fang Cheng, Xiaolei Xue
doaj   +1 more source

The association between serum soluble α-Klotho and thyroid profile among adults from NHANES 2007–2012

BMC Endocrine Disorders
Background Thyroid hormone is the key endocrine regulator of growth, development, metabolism, and other bodily functions. α-Klotho has been involved in the aging process and acts as an endocrine factor involved in the regulation of various metabolic ...
Jing Dong, Min Liu, Guangda Xiang, Ling Yue, Xiaoli Xu, Lin Xiang   +5 more
doaj   +1 more source

Characterization of the zebrafish orthologue of Klotho. [PDF]

, 2011
Klotho is a multi-functional anti-ageing protein. Its deletion causes accelerated ageing in mice while its overexpression increases mouse longevity. Klotho is a single pass transmembrane protein and its extracellular domain is cleaved at the cell surface
Sugano, Yuya
core  

Association Between Serum Klotho and Chronic Obstructive Pulmonary Disease in US Middle-Aged and Older Individuals: A Cross-Sectional Study from NHANES 2013–2016

Yushan Shi,1,* Zhangmeng Xu,2,* Shuangshuang Pu,1 Kanghong Xu,1 Yanan Wang,1 Chunlai Zhang1 1Department of Laboratory Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 25000, People’s Republic ...
Xu K, Wang Y, Zhang C, Xu Z, Pu S, Shi Y
core