Klotho and phosphate are modulators of pathologic uremic cardiac remodeling
Cardiac dysfunction in CKD is characterized by aberrant cardiac remodeling with hypertrophy and fibrosis. CKD is a state of severe systemic Klotho deficiency, and restoration of Klotho attenuates vascular calcification associated with CKD.
Faul, Christian +15 more
core +1 more source
Renal Klotho in mineral metabolism [Elektronisk resurs]
Calcium and phosphorous are critical elements in a number of physiological processes, including maintenance of bone structure, cell signaling and energy metabolism.
Amin, R
core
Białko Klotho a przewlekła choroba nerek [PDF]
W 1997 roku dr Kuro-o i wsp. odkryli gen Klotho i nazwali go imieniem jednej z Mojr (tej, która nawijała na wrzeciono nić życia). Ekspresja białka Klotho zachodzi w różnych tkankach, szczególnie cewkach dystalnych w nerce, splocie naczyniówkowym w mózgu ...
Małyszko, Jolanta; Klinika Nefrologii i Transplantologii Uniwersytetu Medycznego w Białymstoku
core
Background and Objective Klotho is a protein that is closely related to human aging. Soluble Klotho (S-Klotho) is a circulating protein, and its level decreases in response to systemic inflammation.
Caijuan Huang +4 more
doaj +1 more source
Pharmaceutical Strategies for Translating Klotho-Based Therapeutics: From Biologic Developability to Advanced Delivery Systems. [PDF]
Zeng L, Chen X, Li Y, Xiong W.
europepmc +1 more source
Serum Alpha-Klotho and Coronary Atherosclerosis: Associations with Coronary CT Angiography Findings and Atherogenic Indices. [PDF]
Tuzcu A +5 more
europepmc +1 more source
Characterization of Umbilical Cord Mesenchymal Stromal Cells Overexpressing Klotho and In Vitro Anti-Aging Efficacy of Their Derived Extracellular Vesicles. [PDF]
Zhang A +8 more
europepmc +1 more source
Endocrine crosstalk in cardiovascular-kidney-metabolic syndrome-related heart failure: the fibroblast growth factor 23-Klotho axis and cardiometabolic therapy. [PDF]
Sun D +5 more
europepmc +1 more source

