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Current Opinion in Nephrology and Hypertension, 2012
The klotho gene was originally identified as a putative aging-suppressor gene in mice that extended life span when overexpressed and induced a premature aging syndrome when disrupted. Subsequently, it became clear that the Klotho family of membrane proteins function as obligate co-receptors for endocrine fibroblast growth factors (FGFs) that regulate ...
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The klotho gene was originally identified as a putative aging-suppressor gene in mice that extended life span when overexpressed and induced a premature aging syndrome when disrupted. Subsequently, it became clear that the Klotho family of membrane proteins function as obligate co-receptors for endocrine fibroblast growth factors (FGFs) that regulate ...
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Establishment of the Anti-Klotho Monoclonal Antibodies and Detection of Klotho Protein in Kidneys
Biochemical and Biophysical Research Communications, 2000A novel gene, klotho (kl), which is involved in the development of a syndrome resembling human aging in mice, was recently identified. The kl gene encodes a single-pass membrane protein whose extracellular domain carries homology to beta-glucosidases. There also exists a splice variant of kl mRNA which encodes a putative secreted protein in both human ...
Y, Kato +16 more
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Klotho: a novel biomarker for cancer
Journal of Cancer Research and Clinical Oncology, 2014The Klotho gene was originally identified as an anti-aging gene in 1997. Recent studies have demonstrated aberrant expression of Klotho in a number of cancers, including breast cancer, lung cancer, hepatocellular carcinoma (HCC), and so on.A literature search focusing on dysregulation of Klotho and its possible mechanisms in cancer was performed ...
Xiangxiang, Zhou, Xin, Wang
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Nihon rinsho. Japanese journal of clinical medicine, 2004
The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes(e.g. arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, short lifespan). We have shown that mice deficient for the klotho gene show endothelial dysfunction as manifested by an attenuated response of aortic relaxation in ...
Yuichiro, Saito +2 more
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The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes(e.g. arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, short lifespan). We have shown that mice deficient for the klotho gene show endothelial dysfunction as manifested by an attenuated response of aortic relaxation in ...
Yuichiro, Saito +2 more
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Toward a Better Understanding of Klotho
Science of Aging Knowledge Environment, 2006klotho mutant mice were originally described as a short-lived mouse model with premature aging-like disorders. The klotho gene responsible for these phenotypes encodes a type I membrane protein with a considerable similarity to β-glycosidase.
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2021
During the evolution of skeletons, vertebrates acquired the bone made of calcium phosphate. By keeping the extracellular fluid in a supersaturated condition regarding calcium and phosphate, vertebrates create the bone when and where they want simply by providing a cue for precipitation.
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During the evolution of skeletons, vertebrates acquired the bone made of calcium phosphate. By keeping the extracellular fluid in a supersaturated condition regarding calcium and phosphate, vertebrates create the bone when and where they want simply by providing a cue for precipitation.
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Klotho protein and insulin resistance
Clinica Chimica ActaKlotho was initially identified as an anti-ageing protein expressed mainly in renal distal tubular cells and the choroid plexus. The Klotho family comprises several members, including α-Klotho (αKl), β-Klotho (βKl), Klotho-LPH related protein (KLPH; lactase-phlorizin hydrolase), and Klotho-related protein (KlrP), which perform a multitude of functions ...
Yaqin, Cai +6 more
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Klotho Prevents Translocation of NFκB
2016Klotho protein is a β-glucuronidase capable of hydrolyzing steroid β-glucuronides. Two molecules are produced by the Klotho gene, a membrane bound form and a circulating form. This protein is recognized as an antiaging gene with pleiotropic functions.
P, Buendía +3 more
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The Klotho proteins in health and disease
Nature Reviews Nephrology, 2018The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity binding of FGF19, FGF21 and FGF23 to their cognate FGF receptors (FGFRs). Collectively, these proteins form a unique endocrine system that governs multiple metabolic processes in ...
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Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans
EBioMedicine, 2022Yi Zhu +2 more
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