Results 191 to 200 of about 17,091 (230)

Serum Klotho Levels and Major Age-Related Ocular Disorders: A Cross-Sectional and Genetic Association Study. [PDF]

Transl Vis Sci Technol
Guo R, Song M, Liu W.
europepmc   +1 more source

Recent research progress on the etiology and pathogenesis of tumor-induced osteomalacia: A review. [PDF]

J Bone Oncol
Liu S, Xing J, Song A, Liu Y, Xia W.
europepmc   +1 more source

Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group. [PDF]

Calcif Tissue Int
Guldan M, Ozbek L, Fidan DG, Narin AE, Hansen D, Diaz-Tocados JM, Haarhaus M, de Borst MH, Alfieri C, Ferraro PM, Bellasi A, Kanbay M.   +11 more
europepmc   +1 more source

Correction to: "Alpha-klotho, Insulin Resistance, and Adiposity Among Older Adults". [PDF]

J Endocr Soc
europepmc   +1 more source

Current understanding of klotho [PDF]

Ageing Research Reviews, 2009
Klotho is a new anti-aging gene. Genetic mutation of klotho causes multiple premature aging-like phenotypes and strikingly shortens lifespan. Overexpression of the klotho gene in mice suppresses aging and extends lifespan which may involve the mechanism of suppression of insulin signaling and oxidant stress.
Zhongjie Sun
exaly   +3 more sources

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Klotho

Pflügers Archiv - European Journal of Physiology, 2009
The klotho gene was identified as an "aging-suppressor" gene in mice that accelerates aging when disrupted and extends life span when overexpressed. It encodes a single-pass transmembrane protein and is expressed primarily in renal tubules. The extracellular domain of Klotho protein is secreted into blood and urine by ectodomain shedding. The two forms
openaire   +2 more sources

Klotho and kidney disease

Journal of Nephrology, 2010
Abstract Klotho is a single-pass transmembrane protein that exerts its biological functions through multiple modes. Membrane-bound Klotho acts as coreceptor for the major phosphatonin fibroblast growth factor-23 (FGF23), while soluble Klotho functions as an endocrine substance.
Ming-Chang, Hu, Makoto, Kuro-o, Orson W, Moe   +2 more
openaire   +2 more sources

Klotho and βKlotho

2012
Endocrine fibroblast growth factors (FGFs) have been recognized as hormones that regulate a variety of metabolic processes. FGF19 is secreted from intestine upon feeding and acts on liver to suppress bile acid synthesis. FGF21 is secreted from liver upon fasting and acts on adipose tissue to promote lipolysis and responses to fasting. FGF23 is secreted
openaire   +2 more sources

Klotho in health and disease

Current Opinion in Nephrology and Hypertension, 2012
The klotho gene was originally identified as a putative aging-suppressor gene in mice that extended life span when overexpressed and induced a premature aging syndrome when disrupted. Subsequently, it became clear that the Klotho family of membrane proteins function as obligate co-receptors for endocrine fibroblast growth factors (FGFs) that regulate ...
openaire   +2 more sources

Establishment of the Anti-Klotho Monoclonal Antibodies and Detection of Klotho Protein in Kidneys

Biochemical and Biophysical Research Communications, 2000
A novel gene, klotho (kl), which is involved in the development of a syndrome resembling human aging in mice, was recently identified. The kl gene encodes a single-pass membrane protein whose extracellular domain carries homology to beta-glucosidases. There also exists a splice variant of kl mRNA which encodes a putative secreted protein in both human ...
Y, Kato, E, Arakawa, S, Kinoshita, A, Shirai, A, Furuya, K, Yamano, K, Nakamura, A, Iida, H, Anazawa, N, Koh, A, Iwano, A, Imura, T, Fujimori, M, Kuro-o, N, Hanai, K, Takeshige, Y, Nabeshima   +16 more
openaire   +2 more sources