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Aging and FGF23-klotho system

2021
During the evolution of skeletons, vertebrates acquired the bone made of calcium phosphate. By keeping the extracellular fluid in a supersaturated condition regarding calcium and phosphate, vertebrates create the bone when and where they want simply by providing a cue for precipitation.
openaire   +2 more sources

[klotho gene].

Nihon rinsho. Japanese journal of clinical medicine, 2004
The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes(e.g. arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, short lifespan). We have shown that mice deficient for the klotho gene show endothelial dysfunction as manifested by an attenuated response of aortic relaxation in ...
Yuichiro, Saito   +2 more
openaire   +1 more source

Klotho protein and insulin resistance

Clinica Chimica Acta
Klotho was initially identified as an anti-ageing protein expressed mainly in renal distal tubular cells and the choroid plexus. The Klotho family comprises several members, including α-Klotho (αKl), β-Klotho (βKl), Klotho-LPH related protein (KLPH; lactase-phlorizin hydrolase), and Klotho-related protein (KlrP), which perform a multitude of functions ...
Yaqin, Cai   +6 more
openaire   +2 more sources

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans

EBioMedicine, 2022
Allyson Palmer   +2 more
exaly  

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Frontiers in Endocrinology, 2020
Paul G Shiels   +2 more
exaly  

[Klotho mice and klotho gene].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1998
J, Nakura, T, Miki
openaire   +1 more source

The relevance of α-KLOTHO to the central nervous system: Some key questions

Ageing Research Reviews, 2017
Marina M Cararo-Lopes   +2 more
exaly  

The role of the anti-ageing protein Klotho in vascular physiology and pathophysiology

Ageing Research Reviews, 2017
Rik Mencke, Jan-Luuk Hillebrands
exaly  

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