Results 91 to 100 of about 11,920 (192)

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Association of glucagon‐like peptide‐1 receptor agonist use with clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 766-780, May 2026.
This TriNetX (US, 2016–2023) study compared clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes treated with GLP‐1 receptor agonists vs DPP4 inhibitors. ABSTRACT Objectives To evaluate whether glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are associated with improved survival and renal outcomes in patients with ...
Yu‐Ting Yu, Ying Chun Lee, Yu‐Wei Fang, Wen‐Hui Hsieh, Ming‐Hsien Tsai   +4 more
wiley   +1 more source

Gender-specific association between circulating serum Klotho and metabolic components in adults

BMC Endocrine Disorders
Background Klotho plays a pivotal role in human aging. Metabolic syndrome (MetS) is composed of multiple conditions that are also risk factors for cardiovascular disease and diabetes.
Zhenzhen Wang, Hang Zhang, Guixia Zheng, Zheng Wang, Lei Shi   +4 more
doaj   +1 more source

Sex differences in the association between serum α-Klotho levels and hyperlipidemia: a cross-sectional study from NHANES 2013–2016

Scientific Reports
This study assessed the association between serum α-Klotho levels and hyperlipidemia. The aim was to ascertain the potential of serum α-Klotho levels as a predictive biomarker for hyperlipidemia.
Yu Han, Chao Liu, Ying Nie, Xijuan Jiang, Na An, Yabin Qin, Yinghua Ma, Zhihua An, Yile Zhao   +8 more
doaj   +1 more source

Klotho-mediated activation of the anti-oxidant Nrf2/ARE signal pathway affects cell apoptosis, senescence and mobility in hypoxic human trophoblasts: involvement of Klotho in the pathogenesis of preeclampsia

Cell Division
The anti-aging gene Klotho is implicated in the pathogenesis of preeclampsia (PE), which is a pregnancy disease characterized by hypertension and proteinuria.
Baomei Xu, Fang Cheng, Xiaolei Xue
doaj   +1 more source

Update on FGF23 and Klotho signaling

Molecular and Cellular Endocrinology, 2016
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone known to suppress phosphate reabsorption and vitamin D hormone production in the kidney. Klotho was originally discovered as an anti-aging factor, but the functional role of Klotho is still a controversial issue. Three major functions have been proposed, a hormonal function of soluble Klotho,
openaire   +2 more sources

The association between serum soluble α-Klotho and thyroid profile among adults from NHANES 2007–2012

BMC Endocrine Disorders
Background Thyroid hormone is the key endocrine regulator of growth, development, metabolism, and other bodily functions. α-Klotho has been involved in the aging process and acts as an endocrine factor involved in the regulation of various metabolic ...
Jing Dong, Min Liu, Guangda Xiang, Ling Yue, Xiaoli Xu, Lin Xiang   +5 more
doaj   +1 more source

Association between serum α-klotho levels and the incidence of diabetic kidney disease and mortality in type 2 diabetes: evidence from a Chinese cohort and the NHANES database

Diabetology & Metabolic Syndrome
Background The α-klotho is crucial in diabetes and its related complications. This study seeks to explore the link between α-klotho levels and the risk of diabetic kidney disease (DKD) as well as all-cause and cardiovascular mortality among individuals ...
Yi Kang, Qian Jin, Mengqi Zhou, Huijuan Zheng, Danwen Li, Jingwei Zhou, Jie Lv, Yaoxian Wang   +7 more
doaj   +1 more source

P2X7 receptors and klotho [PDF]

Purinergic Signalling, 2020
openaire   +2 more sources

The effects of Klotho delivering mesenchymal stem cell-derived small extracellular vesicles on acute kidney injury

Journal of Nanobiotechnology
Acute kidney injury (AKI) is a life-threating syndrome characterized by sudden loss of kidney function, and its management is challenging and often suboptimal.
Xiao-Hui Deng, Zi-Cong Wu, Qi Sun, Long-Xin Huang, Ying-Chun Xie, Dong-Xiao Lou, Chan-Gu Li, Xiao-Qing Liu, Zhi-Rou Zhou, Tian Tian, Chang-Lin Lian, Qing-Ling Fu   +11 more
doaj   +1 more source