Results 91 to 100 of about 17,091 (230)

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

Life Extension Factor Klotho Enhances Cognition [PDF]

, 2014
SummaryAging is the primary risk factor for cognitive decline, an emerging health threat to aging societies worldwide. Whether anti-aging factors such as klotho can counteract cognitive decline is unknown. We show that a lifespan-extending variant of the
Kramer, Joel H., Yu, Gui-Qiu, Lei Yu, Gary W. Small, Wang, Dan, Sturm, Virginia E., Ho, Kaitlyn, Carmela R. Abraham, Mucke, Lennart, Lauren Broestl, Dubal, Dena B., Worden, Kurtresha, Zhu, Lei, Kurtresha Worden, Makoto Kuro-o, Kirsten E. Eilertson, David A. Bennett, Eilertson, Kirsten E, Kim, Daniel, Virginia E. Sturm, Daniel Kim, Miller, Bruce L., Klein, Eric, Small, Gary W., Abraham, Carmela R., Lei Zhu, Eilertson, Kirsten E., Philip L. De Jager, Kaitlyn Ho, Small, Gary W, Kramer, Joel H, Coppola, Giovanni, Bennett, David A, Joel H. Kramer, Bruce L. Miller, Abraham, Carmela R, Lennart Mucke, Sturm, Virginia E, Dan Wang, Gui-Qiu Yu, De Jager, Philip L, Miller, Bruce L, Broestl, Lauren, Dubal, Dena B, Bennett, David A., Eric Klein, Dena B. Dubal, De Jager, Philip L., Yu, Lei, Yokoyama, Jennifer S, Giovanni Coppola, Kuro-o, Makoto, Jennifer S. Yokoyama, Yokoyama, Jennifer S.   +53 more
core   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Knockdown of klotho leads to cell movement impairment during zebrafish gastrulation

(1) Background: Klotho is a multifunctional protein, but its biophysiological roles during fish early development are unclear. (2) Methods: We carried out anti-sense Klotho morpholino injection and whole-mount in situ hybridization experiments in this ...
Pan, Heng-Chih;Pan, Heng-Chih;Lo, Kang-Chieh;Wang, Yun-Hsin;Huang, Han-Ting;Cheng, Shu-Chun;Sun, Chiao-Yin;Chen, Yau-Hung
core   +1 more source

Klotho and the Aging Process

The Korean Journal of Internal Medicine, 2011
The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the thread of life.
openaire   +2 more sources

Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients

International Journal of Endocrinology, 2015
Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form.
Naoko Otani-Takei, Takahiro Masuda, Tetsu Akimoto, Sumiko Honma, Yuko Watanabe, Kazuhiro Shiizaki, Takuya Miki, Eiji Kusano, Yasushi Asano, Makoto Kuro-o, Daisuke Nagata   +10 more
doaj   +1 more source

Serum klotho level as an indicator for predicting the progression of renal function in chronic kidney disease stages 3~5

Di-san junyi daxue xuebao, 2020
Objective To investigate the association of serum klotho level with renal function deterioration and whether serum klotho level can be used as a predictor of progression of chronic kidney disease (CKD) into renal end point events.
YANG Jiangxin, XIONG Jiachuan, YANG Ke, ZHAO Jinghong   +3 more
doaj   +1 more source

Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance

Periodontology 2000, EarlyView.
Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf, Ulrike Schulze‐Späte, Thomas Van Dyke, Stefan Wolfart, Thomas Dietrich, Alberto Ortiz, Zhuojun Wu, Joachim Jankowski   +7 more
wiley   +1 more source

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

Correlation between renal Klotho methylation level and renal Klotho immunostaining intensity in 47 patients with CKD.

, 2013
Immunostaining of consecutive kidney sections for Klotho in IgA nephropathy (A) and focal segmental glomerulosclerosis (B). Magnification, x200. Arrows indicate the detection of Klotho mainly in renal tubules.
Han Zhang (110653), Chen Zhang (66790), Qing Wu (277441), Xiaoqiang Ding (411454), Xiaoyan Zhang (50085), Jing Lin (50818), Jing Chen (4762)   +6 more
core   +1 more source