Results 91 to 100 of about 12,216 (191)

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 170-188, June 2026.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Sex differences in the association between serum α-Klotho levels and hyperlipidemia: a cross-sectional study from NHANES 2013–2016

Scientific Reports
This study assessed the association between serum α-Klotho levels and hyperlipidemia. The aim was to ascertain the potential of serum α-Klotho levels as a predictive biomarker for hyperlipidemia.
Yu Han, Chao Liu, Ying Nie, Xijuan Jiang, Na An, Yabin Qin, Yinghua Ma, Zhihua An, Yile Zhao   +8 more
doaj   +1 more source

Update on FGF23 and Klotho signaling

Molecular and Cellular Endocrinology, 2016
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone known to suppress phosphate reabsorption and vitamin D hormone production in the kidney. Klotho was originally discovered as an anti-aging factor, but the functional role of Klotho is still a controversial issue. Three major functions have been proposed, a hormonal function of soluble Klotho,
openaire   +2 more sources

Gender-specific association between circulating serum Klotho and metabolic components in adults

BMC Endocrine Disorders
Background Klotho plays a pivotal role in human aging. Metabolic syndrome (MetS) is composed of multiple conditions that are also risk factors for cardiovascular disease and diabetes.
Zhenzhen Wang, Hang Zhang, Guixia Zheng, Zheng Wang, Lei Shi   +4 more
doaj   +1 more source

Association between serum α-klotho levels and the incidence of diabetic kidney disease and mortality in type 2 diabetes: evidence from a Chinese cohort and the NHANES database

Diabetology & Metabolic Syndrome
Background The α-klotho is crucial in diabetes and its related complications. This study seeks to explore the link between α-klotho levels and the risk of diabetic kidney disease (DKD) as well as all-cause and cardiovascular mortality among individuals ...
Yi Kang, Qian Jin, Mengqi Zhou, Huijuan Zheng, Danwen Li, Jingwei Zhou, Jie Lv, Yaoxian Wang   +7 more
doaj   +1 more source

The effects of Klotho delivering mesenchymal stem cell-derived small extracellular vesicles on acute kidney injury

Journal of Nanobiotechnology
Acute kidney injury (AKI) is a life-threating syndrome characterized by sudden loss of kidney function, and its management is challenging and often suboptimal.
Xiao-Hui Deng, Zi-Cong Wu, Qi Sun, Long-Xin Huang, Ying-Chun Xie, Dong-Xiao Lou, Chan-Gu Li, Xiao-Qing Liu, Zhi-Rou Zhou, Tian Tian, Chang-Lin Lian, Qing-Ling Fu   +11 more
doaj   +1 more source

Klotho-mediated activation of the anti-oxidant Nrf2/ARE signal pathway affects cell apoptosis, senescence and mobility in hypoxic human trophoblasts: involvement of Klotho in the pathogenesis of preeclampsia

Cell Division
The anti-aging gene Klotho is implicated in the pathogenesis of preeclampsia (PE), which is a pregnancy disease characterized by hypertension and proteinuria.
Baomei Xu, Fang Cheng, Xiaolei Xue
doaj   +1 more source

The association between serum soluble α-Klotho and thyroid profile among adults from NHANES 2007–2012

BMC Endocrine Disorders
Background Thyroid hormone is the key endocrine regulator of growth, development, metabolism, and other bodily functions. α-Klotho has been involved in the aging process and acts as an endocrine factor involved in the regulation of various metabolic ...
Jing Dong, Min Liu, Guangda Xiang, Ling Yue, Xiaoli Xu, Lin Xiang   +5 more
doaj   +1 more source

P2X7 receptors and klotho [PDF]

Purinergic Signalling, 2020
openaire   +2 more sources

The association of platelet count, high-density lipoprotein cholesterol, and platelet/high-density lipoprotein cholesterol ratio with serum soluble Klotho

Lipids in Health and Disease
Background and Objective Klotho is a protein that is closely related to human aging. Soluble Klotho (S-Klotho) is a circulating protein, and its level decreases in response to systemic inflammation.
Caijuan Huang, Yibing Guan, Lele Chen, Ying Xu, Haiping Yang   +4 more
doaj   +1 more source