Results 21 to 30 of about 17,091 (230)
Hepatology, EarlyView., 2022 IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu +20 more
wiley +1 more source
Journal of the American Society of Nephrology, 2011 Ectopic calcification of the vasculature comes with age and is also prevalent in patients with chronic kidney disease (CKD). Klotho, a protein highly expressed in the kidney, has been identified as a novel anti-aging factor,[1][1],[2][2] and Klotho-deficient animals develop medial ...
Shroff, Rukshana, Shanahan, Catherine M.
openaire +3 more sources
Molecular Metabolism, 2021 Objective: Our laboratory recently identified the centrally circulating α-klotho protein as a novel hypothalamic regulator of food intake and glucose metabolism in mice. The current study aimed to investigate novel molecular effectors of central α-klotho
Taylor Landry +9 more
doaj +1 more source
Frontiers in Immunology, 2020 Acinetobacter baumannii is an important opportunistic pathogen that primarily afflicts elderly people. To clarify the pathogenicity of A. baumannii in the elderly, we investigated immune responses to A.
Yoshinori Sato +3 more
doaj +1 more source
Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma. [PDF]
PLoS ONE, 2013 Klotho was originally characterized as an aging suppressor gene that predisposed Klotho-deficient mice to premature aging-like syndrome. Although Klotho was recently reported to exhibit tumor suppressive properties during various malignant ...
Lin Chen +14 more
doaj +1 more source
The Role of Soluble α-klotho Protein in Acromegaly [PDF]
, 2023 Soluble α-klotho (sαKl) is an isoform of the α-klotho protein that regulates calcium metabolism but also has anti-aging, anti-apoptotic, and tumor suppressor effects.
Carmen Emanuela GEORGESCU, Oana PINZARIU
core +2 more sources
Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy.
PLoS ONE, 2021 The anti-aging gene, klotho, has been identified as a multi-functional humoral factor and is implicated in multiple biological processes. However, the effects of klotho on podocyte injury in diabetic nephropathy are poorly understood.
Jeong Suk Kang +8 more
doaj +1 more source
Klotho in vascular biology [PDF]
, 2018 Klotho is a protein named for the Greek goddess who spins the thread of life. This is a fitting name, as the Klotho protein has been characterized as an anti-ageing factor. Klotho is mainly produced in the kidney.
Mencke, Rik
core +28 more sources
Scientific Reports, 2021 The Naked Mole Rat (NMR), Heterocephalus glaber, provides an interesting model for studying biomarkers of longevity due to its long lifespan of more than 30 years, almost ten times longer than that of mice and rats.
M. Morevati +10 more
doaj +1 more source
Soluble klotho as an effective biomarker to characterize inflammatory states
Annals of Medicine, 2022 Background & Aims Soluble α-Klotho (s-Klotho) is a circulating protein with pleiotropic effects that mainly induce protective effects. Our study investigates the associations between s-Klotho and several established inflammatory biomarkers, with the aim ...
Shou-En Wu, Wei-Liang Chen
doaj +1 more source