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Biochimica et Biophysica Acta (BBA) - General Subjects, 2009 The klotho gene encodes a single-pass transmembrane protein that forms a complex with multiple fibroblast growth factor (FGF) receptors and functions as an obligatory co-receptor for FGF23, a bone-derived hormone that induces negative phosphate balance.
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Klotho and the Treatment of Human Malignancies [PDF]
Cancers, 2020 Klotho was first discovered as an anti-ageing protein linked to a number of age-related disease processes, including cardiovascular, renal, musculoskeletal, and neurodegenerative conditions. Emerging research has also demonstrated a potential therapeutic role for Klotho in cancer biology, which is perhaps unsurprising given that cancer and ageing share
Aishani Sachdeva +6 more
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Kidney International, 2011 Klotho is a putative aging suppressor gene encoding a single-pass transmembrane co-receptor that makes the fibroblast growth factor (FGF) receptor specific for FGF-23. In addition to multiple endocrine organs, Klotho is expressed in kidney distal convoluted tubules and parathyroid cells, mediating the role of FGF-23 in bone-kidney-parathyroid control ...
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The vascular secret of Klotho [PDF]
Kidney International, 2015 Klotho is an evolutionarily highly conserved protein related to longevity. Increasing evidence of a vascular protecting effect of the Klotho protein has emerged and might be important for future treatments of uremic vascular calcification. It is still disputed whether Klotho is locally expressed in the vasculature or whether its vascular effects arise ...
Ewa, Lewin, Klaus, Olgaard
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Soluble α-Klotho Serum Levels in Chronic Kidney Disease
International Journal of Endocrinology, 2015 Transmembrane α-Klotho (TM-Klotho), expressed in renal tubules, is a cofactor for FGF23-receptor. Circulating soluble-α-Klotho (s-Klotho) results from TM-Klotho shedding and acts on Phosphate (P) and Calcium (Ca) tubular transport.
Silverio Rotondi +8 more
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Cell Death and Disease, 2023 Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming growth factor-β2 (TGF-β2) and oxidative stress play a critical role in the progression of age-related macular degeneration (AMD).
Ha Young Jang +3 more
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Klotho is upregulated in human cardiomyopathy independently of circulating Klotho levels [PDF]
Scientific Reports, 2018 AbstractKlotho is an antiaging protein which exerts known cardioprotection. In kidney, trans-membrane Klotho acts as essential co-receptor of fibroblast growth factor 23 (FGF23). In the heart, soluble Klotho (sKlotho) protects from systolic dysfunction independently of FGF23.
G. Poelzl +9 more
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The Organ Handling of Soluble Klotho in Humans
Kidney & Blood Pressure Research, 2019 Background: Chronic kidney disease (CKD) reduces both Klotho expression and its shedding into circulation, an effect that accelerates progression and cardiovascular complications.
Daniela Picciotto +10 more
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microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress.
PLoS ONE, 2019 KLOTHO deficiency is associated with the progression of kidney dysfunction, whereas its overexpression exerts renoprotective effects. Oxidative stress suppresses KLOTHO expression in renal epithelial cells but upregulates microRNA-200c (miR-200c) in ...
Kenichi Morii +8 more
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International Journal of Cell Biology, 2020 Antiaging protein Klotho exhibits impressive properties of anti-inflammation, however is declined early after intervertebral disc injury, making Klotho restoration an attractive strategy of treating intervertebral disc inflammatory disorders.
Fangfang Bi +4 more
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