Results 11 to 20 of about 11,920 (192)
Hepatology, EarlyView., 2022 IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu +20 more
wiley +1 more source
Journal of the American Society of Nephrology, 2011 Ectopic calcification of the vasculature comes with age and is also prevalent in patients with chronic kidney disease (CKD). Klotho, a protein highly expressed in the kidney, has been identified as a novel anti-aging factor,[1][1],[2][2] and Klotho-deficient animals develop medial ...
Shroff, Rukshana, Shanahan, Catherine M.
openaire +3 more sources
Soluble Klotho causes hypomineralization in Klotho-deficient mice [PDF]
Journal of Endocrinology, 2018 The type I transmembrane protein αKlotho (Klotho) serves as a coreceptor for the phosphaturic hormone fibroblast growth factor 23 (FGF23) in kidney, while a truncated form of Klotho (soluble Klotho, sKL) is thought to exhibit multiple activities, including acting as a hormone, but whose mode(s) of action in different organ systems remains to be fully ...
Minamizaki, Tomoko +6 more
openaire +4 more sources
Klotho supplementation reverses renal dysfunction and interstitial fibrosis in remnant kidney.
Kidney & Blood Pressure Research, 2023 Introduction: While recent investigations show that klotho exerts reno-protective actions, it has not been fully addressed whether klotho protein supplementation reverses renal damage.
Tsuneo Takenaka +9 more
doaj +1 more source
Klotho and Renal Fibrosis [PDF]
Nephro-Urology Monthly, 2013 Klotho is a newly discovered protein with pleotropic effects and have affected different fields of renal medicine from translational research to clinical nephrology. Here we want to summarize some new scopes in the field of renal fibrosis and Klotho with this hope that in future it could be implemented as a new therapeutic strategy to combat the renal ...
Zununi Vahed, Sepide +2 more
openaire +2 more sources
Scientific Reports, 2021 The Naked Mole Rat (NMR), Heterocephalus glaber, provides an interesting model for studying biomarkers of longevity due to its long lifespan of more than 30 years, almost ten times longer than that of mice and rats.
M. Morevati +10 more
doaj +1 more source
Soluble klotho as an effective biomarker to characterize inflammatory states
Annals of Medicine, 2022 Background & Aims Soluble α-Klotho (s-Klotho) is a circulating protein with pleiotropic effects that mainly induce protective effects. Our study investigates the associations between s-Klotho and several established inflammatory biomarkers, with the aim ...
Shou-En Wu, Wei-Liang Chen
doaj +1 more source
Interaction of Klotho and sirtuins
Experimental Gerontology, 2023 In this article, we review the articles that have reported the interaction between Klotho and sirtuins.Sirtuins are a family of histone deacetylase enzymes that are considered to be the main regulators of biological processes. This family is one of the essential factors for postponing aging and increasing the life span of organisms.
Farzaneh Rostamzadeh +2 more
openaire +3 more sources
Growth hormone and Klotho [PDF]
Journal of Endocrinology, 2013 Acromegaly is characterized by excessively high GH and IGF1 levels. Recent data suggest that soluble Klotho (sKlotho) is also elevated in patients with active acromegaly. sKlotho decreases towards normal following removal of the GH-producing pituitary adenoma. TheKlothogene was identified in mice following its accidental disruption by ectopic DNA.
Schmid, Christoph +4 more
openaire +2 more sources
EBioMedicine, 2019 Background: The klotho (KL) gene is an anti-aging gene that has recently been shown to also function as a general tumor suppressor. However, there is currently only limited information regarding the potential molecular signals for regulation of Klotho ...
Bo Chen +10 more
doaj +1 more source