Results 11 to 20 of about 17,091 (230)
Klotho, Aging, and the Failing Kidney [PDF]
Frontiers in Endocrinology, 2020 Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of members of the fibroblast growth factor (FGF) family.
Sarah Buchanan +3 more
doaj +6 more sources
Soluble Klotho causes hypomineralization in Klotho-deficient mice [PDF]
Journal of Endocrinology, 2018 The type I transmembrane protein αKlotho (Klotho) serves as a coreceptor for the phosphaturic hormone fibroblast growth factor 23 (FGF23) in kidney, while a truncated form of Klotho (soluble Klotho, sKL) is thought to exhibit multiple activities ...
Kozai, Katsuyuki +13 more
core +7 more sources
Klotho and the treatment of human malignancies [PDF]
Cancers, 2020 Klotho was first discovered as an anti-ageing protein linked to a number of age-related disease processes, including cardiovascular, renal, musculoskeletal, and neurodegenerative conditions. Emerging research has also demonstrated a potential therapeutic
Sachdeva, A. +26 more
core +8 more sources
Circulating Klotho levels: clinical relevance and relationship with tissue Klotho expression [PDF]
Kidney International, 2013 Klotho is a protein that exerts paracrine and endocrine functions. In chronic kidney disease (CKD), its expression is decreased in several tissues. This decrease probably plays important roles in various complications associated with CKD, in both a ...
Massy, Ziad A., Drüeke, Tilman B.
core +4 more sources
Klotho is upregulated in human cardiomyopathy independently of circulating Klotho levels [PDF]
Scientific Reports, 2018 Klotho is an antiaging protein which exerts known cardioprotection. In kidney, trans-membrane Klotho acts as essential co-receptor of fibroblast growth factor 23 (FGF23).
M. M. Zaruba +9 more
core +3 more sources
Clinical Interventions in Aging, 2015 Ao Bian,1,2 Javier A Neyra,3 Ming Zhan,4 Ming Chang Hu1,3 1Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Nephrology, First Affiliated Hospital ...
Bian A, Zhan M, Hu MC, Neyra JA
core +5 more sources
Klotho dataTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Wang, Z (via Mendeley Data)
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O grande papel de Klotho [PDF]
, 2021 Klotho is a single-pass transmembrane protein consisting of 1012 amino acids and expressed strongly and weakly in proximal and distal tubular renal epithelial cells, respectively. There are four groups of Klotho proteins.
Delgado Troche, Fabiana Verónica
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Downregulation of Klotho expression by dehydration
American Journal of Physiology-Renal Physiology, 2011 Klotho, a transmembrane protein, protease, and hormone mainly expressed in renal tissue counteracts aging. Overexpression of Klotho substantially prolongs the life span.
Ganesh Pathare +5 more
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The Interrelated Multifactorial Actions of Cortisol and Klotho: Potential Implications in the Pathogenesis of Parkinson's Disease. [PDF]
, 2022 The pathogenesis of Parkinson's disease (PD) is complex, multilayered, and not fully understood, resulting in a lack of effective disease-modifying treatments for this prevalent neurodegenerative condition.
Clow, A., Corcos, D.M., Luthra, N.S.
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