Results 51 to 60 of about 2,864,852 (356)
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Practical application of SSR-markers in flax breeding (Linum usitatissimum L.)
Аграрная наука Евро-Северо-ВостокаFlax is a promising crop oriented towards industrial use and export. Traditional breeding methods require significant time and labor resources, but modern DNA-markers such as microsatellites significantly accelerate the development of new cultivars and ...
T. A. Bazanov +5 more
doaj +1 more source
AMB Express, 2022 The high cost of cellulase is one of the main obstacles hindering the large-scale biorefining of lignocellulosic biomass. Therefore, developing efficient method for preparation of cellulase is promising.
Cha Cao +8 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
BMC Genomics, 2021 Background Cannabis sativa L., a dioecious plant derived from China, demonstrates important medicinal properties and economic value worldwide. Cannabis properties have been usually harnessed depending on the sex of the plant.
Gen Pan +11 more
doaj +1 more source
Fiber Strong Shape Theory for Topological Spaces [PDF]
, 2017 In the paper we construct and develop a fiber strong shape theory for arbitrary spaces over fixed metrizable space $\Bo$. Our approach is based on the method of Marde\v{s}i\'{c}-Lisica and instead of resolutions, introduced by Marde\v{s}i\'{c}, their ...
Baladze, Vladimer, Tsinaridze, Ruslan
core +2 more sources
A survey on fiber nonlinearity compensation for 400 Gbps and beyond optical communication systems
, 2017 Optical communication systems represent the backbone of modern communication networks. Since their deployment, different fiber technologies have been used to deal with optical fiber impairments such as dispersion-shifted fibers and dispersion ...
Amari, Abdelkerim +5 more
core +1 more source
Fused fiber couplers for fiber photometry
Cell Reports Methods, 2023 In this issue of Cell Reports Methods, Formozov et al. present an innovative fiber photometry system that uses a fused fiber coupler (FFC) instead of a dichroic mirror to split the excitation and emission light. The FFC-based photometry system is highly flexible and can be easily reconfigured to record from different biosensors.
Alex A, Legaria, Alexxai V, Kravitz
openaire +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
IEEE Photonics Journal, 2015 A five-channel frequency-division multiplexing (FDM) fiber laser sensor array based on multilongitudinal mode fiber lasers (MLMFLs) and beat frequency demodulation was proposed. Detailed theoretical analysis of the FDM principle was also described.
X. J. Yu +5 more
doaj +1 more source