Results 61 to 70 of about 6,776,291 (296)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Effects of Reinforcing Fiber Strength on Mechanical Properties of High-Strength Concrete

open access: yesFibers, 2019
This paper investigates the effects of the tensile strength of steel fiber on the mechanical properties of steel fiber-reinforced high-strength concrete.
Hyun-Do Yun   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Investigation of fiber/matrix adhesion: test speed and specimen shape effects in the cylinder test [PDF]

open access: yes, 2013
The cylinder test, developed from the microdroplet test, was adapted to assess the interfacial adhesion strength between fiber and matrix. The sensitivity of cylinder test to pull-out speed and specimen geometry was measured.
Vas, L. M., Czigany, T., Morlin, B.
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

High power, ultra-broadband supercontinuum source based on highly GeO2 doped silica fiber [PDF]

open access: yes, 2017
We demonstrate a 74 mol % GeO2 doped fiber for mid-infrared supercontinuum generation. Experiments ensure a highest output power for a broadest spectrum from 700nm to 3200nm from this fiber, while being pumped by a broadband 4 stage Erbium fiber based ...
Daryl Ho   +11 more
core   +1 more source

High power fiber sources: more than kilowatts [PDF]

open access: yes, 2007
Fiber lasers and amplifiers have reached several kilowatts of output power, and offer many attractions beyond raw power. This tutorial discusses basic scientific and practical issues of fiber sources, and advantages and limitations that derive from ...
Nilsson, J., Johan Nilsson
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

open access: yesFEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual   +3 more
wiley   +1 more source

Research on Dynamic Mechanical Properties and Constitutive Model of Basalt Fiber Reinforced Concrete after Exposure to Elevated Temperatures under Impact Loading

open access: yesApplied Sciences, 2020
The dynamic mechanical properties of basalt fiber reinforced concrete (BFRC) with different fiber contents (0.0%, 0.1%, 0.2%, 0.3%, 0.4%), confining pressures (0 MPa, 5 MPa, 10 MPa, 15 MPa) and exposed to different temperatures (20 °C, 200 °C, 400 °C ...
Wenbiao Liang   +5 more
doaj   +1 more source

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