Results 61 to 70 of about 109,242 (281)

Emerging strategies to target metastasis and therapy resistance in melanoma

Molecular Oncology, EarlyView.
Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley   +1 more source

Flexible lensless endoscope with a conformationally invariant multi-core fiber [PDF]

, 2019
The lensless endoscope represents the ultimate limit in miniaturization of imaging tools: an image can be transmitted through a (multi-mode or multi-core) fiber by numerical or physical inversion of the fiber's pre-measured transmission matrix.
Andresen, Esben Ravn, Baudelle, Karen, Bouwmans, Géraud, Habert, Rémi, Rigneault, Hervé, Sivankutty, Siddharth, Tsvirkun, Viktor, Vanvincq, Olivier   +7 more
core   +4 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Chromatic-Dispersion Monitor Based on a Differential Phase-Shift Method Using a Kerr Phase-Interrogator

IEEE Photonics Journal, 2015
We present a novel approach for real-time chromatic-dispersion (CD) monitoring using a Kerr phase-interrogator. CD induces a differential phase shift between two sinusoidal signals carried by two different wavelengths.
Yang Lu, Chams Baker, Liang Chen, Xiaoyi Bao   +3 more
doaj   +1 more source

Background-free fibre optic Brillouin probe for remote mapping of micromechanics

, 2020
Brillouin spectroscopy is a century-old technique that has recently received renewed interest, as modern instrumentation has transformed it into a powerful contactless and label-free probe of micromechanical properties for biomedical applications.
Basirun, Carin, Chou, Joshua, Gao, Shoufei, Kabakova, Irina V., Török, Peter, Wang, Yingying, Warkiani, Majid E., Xiang, YuChen   +7 more
core   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source

Splitting and Motions of Dissipative Soliton Resonance Pulses in Mode-Locked Fiber Lasers

Frontiers in Physics, 2019
We numerically investigated the splitting and motions of dissipative soliton resonance (DSR) pulses in an all-normal-dispersion Yb-doped fiber laser mode-locked by a non-linear optical loop mirror.
Yanjia Lyu, Chen Wei, Wenxiong Du, Heping Li, Yong Liu   +4 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Methods for Estimation of Optical Fiber Non-Linearity Using Self-Phase Modulation Effect [PDF]

Latvian Journal of Physics and Technical Sciences, 2011
Methods for Estimation of Optical Fiber Non-Linearity Using Self-Phase Modulation Effect Due to ever increasing channel density in WDM systems the nonlinear optical effects in fibers become a limiting factor for the high-speed data transmission, which necessitates determination of such important characteristic as the coefficient of optical ...
A. Supe, J. Porins
openaire   +1 more source