Results 61 to 70 of about 829,663 (306)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

An error analysis of probabilistic fibre tracking methods: average curves optimization [PDF]

, 2009
Fibre tractography using diffusion tensor imaging is a promising method for estimating the pathways of white matter tracts in the human brain. The success of fibre tracking methods ultimately depends upon the accuracy of the fibre tracking algorithms and
Davydov, O., Hojjat, A., Ratnarajah, N., Simmons, A.   +3 more
core  

Modeling cell movement in anisotropic and heterogeneous network tissues [PDF]

, 2007
Cell motion and interaction with the extracellular matrix is studied deriving a kinetic model and considering its diffusive limit. The model takes into account of chemotactic and haptotactic effects, and obtains friction as a result of the interactions ...
Chauviere, A., Hillen, T., Preziosi, Luigi   +2 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Development of Mechanical Extractor for Utilization of Pineapple Leaf Agro-Waste for Textile Application

Journal of Natural Fibers
In Indian subcontinent, pineapple (Ananas Comosus) leaves are left unused after fruits are harvested resulting in a waste of natural resources that contain textile-graded fibers.
Laxmi Kanta Nayak, Nageshkumar T, Prateek Shrivastava, Manisha Jagadale, Haokhothang Baite, Vidya Bhushan Shambhu, Manjunatha B. S.   +6 more
doaj   +1 more source

Design and Simulation of Banana Pseudo-stem Fibre Extracting Raspador (Cylinder) Using FEA Technique

Journal of Natural Fibers, 2023
Development of mechanical fiber extractors without considering engineering knowledge can cause failures of the machine’s components during operations. Therefore, the present study was conducted to examine the structural strength of the banana pseudo-stem
Prateek Shrivastava, Nageshkumar T, Manisha Jagadale, Vidhya Bhushan Shambhu, Laxmi Kanta Nayak   +4 more
doaj   +1 more source

Fibre DFB lasers in a 4x10 Gbit/s WDM link with a single sinc-sampled fibre grating dispersion compensator

, 1998
WDM transmission and dispersion compensation at 40 Gbit/s over 200 km standard fibre is demonstrated on a 100 GHz grid using four high power single-polarisation single-sided output DFB fibre laser based transmitters and a single 4 channel WDM chirped ...
Fu, A., Geiger, H., Ibsen, M., Laming, R.I.   +3 more
core   +1 more source

Modelling selective activation of small myelinated nerve fibres using a monopolar point electrode [PDF]

, 1995
The aim of this study is to investigate theoretically the possibility for activation of small myelinated nerve fibres without activating larger ones when stimulating a nerve fibre bundle using a monopolar point electrode.
Debruyne, F.M.J., Holsheimer, J., Rijkhoff, N.J.M., Rijkhoff, N.J.M., Wijkstra, H.   +4 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Low-Cost Microcontroller-Enabled Embedded System for Assessing Jute Retting Water Quality Parameter

Journal of Natural Fibers
Quality of jute fiber depends to a very great extent on the quality of water used for retting. Efficient assessment of water quality is crucial to enable decision-makers to interpret this information and execute necessary management practices. Hence, the
Prateek Shrivastava, Deb Prasad Ray, Aishani Chowdhury, Nageshkumar T, Manisha Jagadale, V. B. Shambhu, Nilimesh Mridha, D. B. Shakyawar   +7 more
doaj   +1 more source