Results 1 to 10 of about 114,998 (297)

Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation [PDF]

Nature Communications
N- and C-terminal α-synuclein (α-syn) truncations are prevalent in Parkinson’s disease. Effects of the N- and C-terminal residues on α-syn aggregation and fibril propagation are distinct, where the N-terminus dictates fibril structure. Here, the majority
Ryan P. McGlinchey, Sashary Ramos, Emilios K. Dimitriadis, C. Blake Wilson, Jennifer C. Lee   +4 more
doaj   +2 more sources

New imaging tools reveal live cellular collagen secretion, fibril dynamics and network organisation [PDF]

Scientific Reports
Although light microscopy has been used to examine the early trafficking of collagen within the cell, much of our understanding of the detailed organisation of cell deposited collagen is from static electron microscopy studies. To understand the dynamics
Olivia Kent, Eleanor R. Casey, Max Brown, Steven Bell, Matthew C. Ehrman, Michael J. Flagler, Arto Määttä, Adam M. Benham, Timothy J. Hawkins   +8 more
doaj   +2 more sources

Cross‐sectional area on magnetic resonance images of the semitendinosus tendon is strongly related to the collagen fibril diameter [PDF]

Journal of Experimental Orthopaedics
Purpose Using a thin semitendinosus tendon as an autograft is a risk factor for poor clinical outcomes after anterior cruciate ligament reconstruction.
Yushin Mizuno, Junsuke Nakase, Tatsuya Ishikawa, Kazuki Asai, Yasushi Takata, Tomoyuki Kanayama, Takuya Sengoku, Noriyuki Ozaki, Hiroyuki Tsuchiya   +8 more
doaj   +2 more sources

Dialdehyde Cellulose Solution as Reducing Agent: Preparation of Uniform Silver Nanoparticles and In Situ Synthesis of Antibacterial Composite Films with High Barrier Properties

Molecules, 2023
The demand for antimicrobial materials is gradually increasing due to the threat of infections and diseases caused by microorganisms. Silver nanoparticles (AgNPs) are widely used because of their broad-spectrum antimicrobial properties, but their ...
Jinsong Zeng, Xinyi Xiong, Fugang Hu, Jinpeng Li, Pengfei Li   +4 more
doaj   +1 more source

Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein

Biomedicines, 2022
Misfolded toxic forms of alpha-synuclein (α-Syn) have been implicated in the pathogenesis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).
Ebrima Gibbs, Beibei Zhao, Andrei Roman, Steven S. Plotkin, Xubiao Peng, Shawn C. C. Hsueh, Adekunle Aina, Jing Wang, Clay Shyu, Calvin K. Yip, Sung-Eun Nam, Johanne M. Kaplan, Neil R. Cashman   +12 more
doaj   +1 more source

Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions

Biomolecules, 2022
The distinct neuropathological features of the different α-Synucleinopathies, as well as the diversity of the α-Synuclein (α-Syn) intracellular inclusion bodies observed in post mortem brain sections, are thought to reflect the strain diversity ...
Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffeteau, Antoine Loquet, François Ichas   +14 more
doaj   +1 more source

Extraction of Micro- and Nano-Fibrils from Nylon 6/Polypropylene Grafted with Maleic Anhydride/Polypropylene Blended Films [PDF]

علوم و تکنولوژی پلیمر, 2013
Atechnical feasibility study has been conducted on production of nano- and micro-fibrils from nylon 6/polypropylene grafted with maleic anhydride/polypropylene blended films.
E. Bagheban Kochak, E. Fallahi, M. Haghighat Kish   +2 more
doaj   +1 more source

Change in Collagen Fibril Diameter Distribution of Bovine Anterior Cruciate Ligament upon Injury Can Be Mimicked in a Nanostructured Scaffold

Molecules, 2021
More than 200,000 people are suffering from Anterior Cruciate Ligament (ACL) related injuries each year in the US. There is an unmet clinical demand for improving biological attachment between grafts and the host tissue in addition to providing ...
Zhuldyz Beisbayeva, Ainur Zhanbassynova, Gulzada Kulzhanova, Fariza Mukasheva, Cevat Erisken   +4 more
doaj   +1 more source

Morphology Research of Windmill Palm (Trachycarpus fortunei) Material [PDF]

Kemija u Industriji, 2015
Windmill palm (Trachycarpus fortunei) fibre was obtained from different parts of windmill-palm trunk sheath and then treated by sodium hydroxide solution and hydrogen peroxide to obtain the treated palm fibril.
C.-J. Chen, Y. Zhang, J.-J. Jia, M.-X. Wang , G.-H. Wang   +4 more
doaj   +1 more source

?2-Microglobulin Amyloid Fibril-Induced Membrane Disruption Is Enhanced by Endosomal Lipids and Acidic pH [PDF]

, 2014
Although the molecular mechanisms underlying the pathology of amyloidoses are not well understood, the interaction between amyloid proteins and cell membranes is thought to play a role in several amyloid diseases. Amyloid fibrils of ?2-microglobulin (?2m)
A Halle, A Ivankin, AD Petelska, AM Smith, B Boland, B Reed, C Cecchi, C Luquain, CJ Sarell, CL Bergstrom, CM Franzin, D Eisenberg, D Freeman, DE Lee, DP Smith, EE Ambroggio, Eric W. Hewitt, F Ferrone, F Gejyo, G van Meer, H Ohvo-Rekila, HD Gallala, HE White, I Benilova, IJ Morten, J Brotheru, J Brotherus, J Pan, J Villanueva, J Zimmerberg, JH Lee, JN Chebukati, JR Wherrett, JW Becker, K Berthelot, K Ditaranto, Kevin W. Tipping, L Milanesi, L Pieri, L Pieri, L Rajendran, M Arrasate, M Bostrom, M Bucciantini, M Duan, M Garcia-Garcia, M Stefani, MF Sciacca, MFM Engel, MFM Sciacca, MP Fogarty, MR Eftink, MY Porter, N Cremades, N Demaurex, N Liguori, Neil A. Ranson, NM Kad, NP Reynolds, Patrick van der Wel, Paul A. Beales, Rebecca Thompson, RF Chen, S Huterer, S Valleix, S Yamamoto, Sheena E. Radford, SL Myers, Sophia C. Goodchild, T Eichner, T Hayakawa, T Kobayashi, T Kobayashi, T Kobayashi, T Kobayashi, T Ookoshi, T Sheynis, T Umeda, Tania Sheynis, TE Frederick, TE Frederick, TL Williams, TL Williams, TP Knowles, TPJ Knowles, TR Jahn, TR Jahn, V Soura, VJ McParland, VN Uversky, Wei-Feng Xue, WF Xue, WF Xue, WF Xue, WF Xue, WF Xue, WG Wood, Y Hirakura, ZS Ji   +98 more
core   +14 more sources