Results 71 to 80 of about 127,967 (338)

The interplay of intrinsic disorder and macromolecular crowding on {\alpha}-synuclein fibril formation

open access: yes, 2016
{\alpha}-synuclein ({\alpha}-syn) is an intrinsically disordered protein which is considered to be one of the causes of Parkinson's disease. This protein forms amyloid fibrils when in a highly concentrated solution.
Kikuchi, Macoto, Shirai, Nobu C.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

The quiet Sun's magnetic flux estimated from CaIIH bright inter-granular G-band structures [PDF]

open access: yes, 2008
We determine the number density and area contribution of small-scale inter-granular calcium-II bright G-band structures in images of the quiet Sun as tracers of kilo-Gauss magnetic flux-concentrations.
B. Bovelet   +24 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Relationships between the tensile strength and diameter of collagen fibrils isolated from mouse tail tendons

open access: yesJournal of Biomechanical Science and Engineering, 2017
The purpose of the present study is to determine the tensile properties of the single collagen fibrils with various diameters using our original tensile test method. The fibrils were directly isolated from mouse tail tendons.
Noritaka YAMAMOTO, Shun NAKAMURA
doaj   +1 more source

Flaw-tolerance in silk fibrils explains strength, extensibility and toughness of spider silk [PDF]

open access: yes, 2011
Silk is an ancient but remarkably strong, extensible and tough material made from simple protein building blocks. Earlier work has shown that the particular molecular geometry of silk with a composite of semi-amorphous and nanocrystalline beta-sheet ...
Markus J. Buehler, Melis Arslan
core   +2 more sources

Protein O‐glycosylation in the Bacteroidota phylum

open access: yesFEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns   +2 more
wiley   +1 more source

Curcumin Reduces Amyloid Fibrillation of Prion Protein and Decreases Reactive Oxidative Stress

open access: yesPathogens, 2013
Misfolding and aggregation into amyloids of the prion protein (PrP) is responsible for the development of fatal transmissible neurodegenerative diseases.
Raymond Chung   +4 more
doaj   +1 more source

Spatial extent of charge repulsion regulates assembly pathways for lysozyme amyloid fibrils. [PDF]

open access: yesPLoS ONE, 2011
Formation of large protein fibrils with a characteristic cross β-sheet architecture is the key indicator for a wide variety of systemic and neurodegenerative amyloid diseases.
Shannon E Hill   +3 more
doaj   +1 more source

Penumbral micro-jets at high spatial and temporal resolution

open access: yes, 2019
Sunspot observations in chromospheric spectral lines have revealed the existence of short-lived linear bright transients, commonly referred to as penumbral micro-jets (PMJs).
Drews, Ainar, van der Voort, Luc Rouppe
core   +1 more source

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