RHYTHM-AF: design of an international registry on cardioversion of atrial fibrillation and characteristics of participating centers [PDF]
BACKGROUND Atrial fibrillation is a serious public health problem posing a considerable burden to not only patients, but the healthcare environment due to high rates of morbidity, mortality, and medical resource utilization. There are limited data on the
AJ Camm+36 more
core +3 more sources
Introduction. Growing evidence suggests that fibrotic changes can be observed in atrial fibrillation (AF) in both atria. Quantification of the scar burden during electroanatomical mapping might have important therapeutic and prognostic consequences ...
Szilvia Herczeg+7 more
doaj +1 more source
Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose–response meta-analysis of prospective studies [PDF]
Different adiposity measures have been associ- ated with increased risk of atrial fibrillation, however, results have previously only been summarized for BMI. We therefore conducted a systematic review and meta- analysis of prospective studies to clarify
Aune, D+8 more
core +1 more source
Major Outcomes in Atrial Fibrillation Patients with One Risk Factor: Impact of Time in Therapeutic Range [PDF]
BACKGROUND: The benefits and harms of oral anticoagulation (OAC) therapy in patients with only one stroke risk factor (i.e. CHA2DS2-VASc= 1 in males, or 2 in females) has been subject of debate.
Lip, Gregory Y. H., Proietti, Marco
core +2 more sources
Dichlorotriazine reactive crosslinker has been used to reduce the fibrillation of Lyocell. The fibrillation propensity and mechanism of 4, 6-dichloro-2-sodium dioxy-1, 3, 5-triazine treatment on Lyocell fibers were studied, and the mechanical properties ...
Zhongkai Xu+7 more
doaj +1 more source
Amyloid Fibril Solubility [PDF]
It is well established that amyloid fibril solubility is protein specific, but how solubility depends on the interactions between the fibril building blocks is not clear. Here we use a simple protein model and perform Monte Carlo simulations to directly measure the solubility of amyloid fibrils as a function of the interaction between the fibril ...
arxiv +1 more source
Current clinician perspective on non-vitamin K antagonist oral anticoagulant use in challenging clinical cases. [PDF]
OBJECTIVE: The evolution of non-vitamin K antagonist anticoagulants (NOACs) has changed the horizon of stroke prevention in atrial fibrillation (SPAF).
Acar, RD+12 more
core +1 more source
Advanced-Glycation Endproducts: How cross-linking properties affect the collagen fibril behavior [PDF]
Advanced-Glycation-Endproducts (AGEs) are known to be a major cause of impaired tissue material properties. In collagen fibrils, the main building component of human tissue, these AGEs appear as fibrillar cross-links. When AGEs accumulate in collagen fibrils, a process often caused by diabetes and aging, the mechanical properties of the collagen fibril
arxiv
The burden of proof: the current state of atrial fibrillation prevention and treatment trials [PDF]
Atrial fibrillation (AF) is an age-related arrhythmia of enormous socioeconomic significance. In recent years, our understanding of the basic mechanisms that initiate and perpetuate AF has evolved rapidly, catheter ablation of AF has progressed from ...
Calkins, Hugh+12 more
core +1 more source
Quiescent Elongation of α-Synuclein Pre-form Fibrils Under Different Solution Conditions
The intracellular aggregation of α-synuclein in neurons/glia is considered to be a key step in the pathogenesis of synucleinopathy [including Parkinson’s disease (PD), dementia with Lewy body (DLB), multiple system atrophy (MSA), etc.].
Hengxu Mao+6 more
doaj +1 more source