Results 31 to 40 of about 268,185 (235)

Impaired Cardiac AMPK (5′‐Adenosine Monophosphate‐Activated Protein Kinase) and Ca2+‐Handling, and Action Potential Duration Heterogeneity in Ibrutinib‐Induced Ventricular Arrhythmia Vulnerability

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We recently demonstrated that acute administration of ibrutinib, a Bruton's tyrosine kinase inhibitor used in chemotherapy for blood malignancies, increases ventricular arrhythmia (VA) vulnerability.
Yanan Zhao, Beibei Du, Praloy Chakraborty, Nathan Denham, Stéphane Massé, Patrick F.H. Lai, Mohammed Ali Azam, Filio Billia, Paaladinesh Thavendiranathan, Husam Abdel‐Qadir, Gary D. Lopaschuk, Kumaraswamy Nanthakumar   +11 more
doaj   +1 more source

Glycemic control is associated with atrial structural remodeling in patients with type 2 diabetes

BMC Cardiovascular Disorders, 2019
Background Diabetes mellitus (DM) has been demonstrated to be a strong risk factor for development and perpetuation of atrial fibrillation (AF). However, how DM and glycemic control affect the pathogenesis of AF has not been sufficiently investigated ...
Qing Wang, Jing Wang, Pei Wang, Liaoyuan Wang, Lanting Jia, Xinyu Ling, Wang Xi, Jie Min, Hua Shen, Jian Xiao, Jinxiang Yuan, Zhinong Wang   +11 more
doaj   +1 more source

Polymorphism in alpha-synuclein oligomers and its implications in toxicity under disease conditions

Frontiers in Molecular Biosciences, 2022
The major hallmark of Parkinson’s disease (PD) is represented by the formation of pathological protein plaques largely consisting of α-synuclein (αSN) amyloid fibrils.
Je Min Yoo, Yuxi Lin, Yunseok Heo, Young-Ho Lee, Young-Ho Lee, Young-Ho Lee, Young-Ho Lee   +6 more
doaj   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen, Xiao‐Xue Wang, Shao‐Rui Bao, Sui‐Li Lin, Mei‐Chun Shu, Xi‐Xi Ye, Wen‐Jie Cong   +6 more
wiley   +1 more source

Nonsustained Atrial Fibrillation in Ischemic Stroke Patients and Stroke‐Free Controls From the Perspective of Stroke Pathophysiology

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundShort‐lasting (
Ezgi Yetim, Mehmet Akif Topcuoglu, Ugur Canpolat, Rahsan Gocmen, Kader K. Oguz, Necla Ozer, Kudret Aytemir, Ethem Murat Arsava   +7 more
doaj   +1 more source

Prediction Model for Etiologic Differentiation of Isolated Vestibular Syndrome in Emergency Settings

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to develop and validate a predictive model for differentiating central from peripheral etiologies in patients with isolated vestibular syndrome (VS). Methods In this multicenter retrospective cohort study, 506 patients with isolated VS from five hospitals were divided into derivation (n = 301) and validation (n = 205)
Guo Wenting, Du Liping, Yang Yi, Hu Jin, Ye Bijun, Wang Jianer, Liu Shuangsi, Guo Shunyuan, Cai Xiaofeng, Wang Huiyuan, Wu Bin, Yu Xiang, Shi Tianming   +12 more
wiley   +1 more source

Physicians’ Perceptions of Their Patients’ Attitude and Knowledge of Long-Term Oral Anticoagulant Therapy in Bulgaria

Medicina, 2019
Background and Objectives: Oral anticoagulation (OAC) is widely used in daily clinical practice worldwide for various indications. We aimed to explore the perception of Bulgarian clinicians about their patients’ attitude and knowledge of long-term ...
Nikolay Runev, Tatjana Potpara, Stefan Naydenov, Anita Vladimirova, Gergana Georgieva, Emil Manov   +5 more
doaj   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source

Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams, Malachi Keo, Jennifer Guo, Daire Daly, Richard Ahern, Kimon Zachary, Gregory Robbins, Rajesh T. Gandhi, Bragi Sveinsson, Adam de Havenon, Kevin N. Sheth, Otto Rapalino, Juan Eugenio Iglesias Gonzales, W. Taylor Kimberly, Shibani S. Mukerji   +14 more
wiley   +1 more source

Nanoparticles With a Specific Size and Surface Charge Promote Disruption of the Secondary Structure and Amyloid-Like Fibrillation of Human Insulin Under Physiological Conditions

Frontiers in Chemistry, 2019
Nanoparticles attract much interest as fluorescent labels for diagnostic and therapeutic tools, although their applications are often hindered by size- and shape-dependent cytotoxicity.
Alyona Sukhanova, Alyona Sukhanova, Simon Poly, Svetlana Bozrova, Éléonore Lambert, Maxime Ewald, Alexander Karaulov, Michael Molinari, Igor Nabiev, Igor Nabiev   +9 more
doaj   +1 more source