Results 31 to 40 of about 23,678,950 (225)

A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion. [PDF]

J Biol Chem, 2019
Fibrillins serve as scaffolds for the assembly of elastic fibers that contribute to the maintenance of tissue homeostasis and regulate growth factor signaling in the extracellular space.
Del Cid JS, Reed NI, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB.   +9 more
europepmc   +2 more sources

Extracellular Regulation of Bone Morphogenetic Protein Activity by the Microfibril Component Fibrillin-1

Journal of Biological Chemistry, 2016
Since the discovery of bone morphogenetic proteins (BMPs) as pluripotent cytokines extractable from bone matrix, it has been speculated how targeting of BMPs to the extracellular matrix (ECM) modulates their bioavailability. Understanding these processes
Alexander P. Wohl, Helen Troilo, Richard F. Collins, Clair Baldock, Gerhard Sengle   +4 more
openalex   +2 more sources

Ca2+-dependent Interface Formation in Fibrillin-1 [PDF]

Journal of Biological Chemistry, 2005
The calcium-binding epidermal growth factor-like (cbEGF) domain is a common structural motif in extracellular and transmembrane proteins. K(d) values for Ca2+ vary from the millimolar to nanomolar range; however the molecular basis for this variation is poorly understood.
Sacha A. Jensen, Adam R. Corbett, Vroni Knott, Christina Redfield, Penny A. Handford   +4 more
openalex   +4 more sources

Fibrillin-1 and −2 contain heparin-binding sites important for matrix deposition and that support cell attachment [PDF]

Biochemical Journal, 2003
Claudio C Werneck
exaly   +2 more sources

Acromicric dysplasia caused by a mutation of fibrillin 1 in a family: A case report. [PDF]

World J Clin Cases, 2023
Shen R, Feng JH, Yang SP.
europepmc   +2 more sources

Fibulin-5 interacts with fibrillin-1 molecules and microfibrils [PDF]

Biochemical Journal, 2005
Fibulin-5 plays an important role in elastic fibre formation in vivo. We have investigated the molecular interactions between fibulin-5 and components of fibrillin-rich microfibrils which form a template for elastin. Fibulin-5 interacted in a dose-dependent manner with a fibrillin-1 N-terminal sequence and with tropoelastin, but not with MAGP-1 ...
Lyle J. Freeman, Amanda Lomas, Nigel W. Hodson, Michael J. Sherratt, Kieran T. Mellody, Anthony S. Weiss, Adrian Shuttleworth, Cay M. Kielty   +7 more
openalex   +5 more sources

Macromolecular crowding enhances fibrillin-1 deposition in the extracellular matrix [PDF]

European Cells & Materials, 2022
Biochemical and biophysical factors need consideration when modelling in vivo cellular behaviour using in vitro cell culture systems. One underappreciated factor is the high concentration of macromolecules present in vivo, which is typically not ...
B Satz-Jacobowitz, N Taye, SZ Karoulias, D Hubmacher   +3 more
doaj   +1 more source

Novel fibrillin-1 mutation with variable presentation as a thoracic aortic aneurysm and intramural hematoma. [PDF]

JTCVS Tech, 2021
Brahmandam A, Vallabhajosyula P.
europepmc   +3 more sources

Protein Interaction Studies of MAGP-1 with Tropoelastin and Fibrillin-1 [PDF]

Journal of Biological Chemistry, 2001
Elastic fibers consist primarily of an amorphous elastin core associated with microfibrils, 10-12 nm in diameter, containing fibrillins and microfibril-associated glycoproteins (MAGPs). To investigate the interaction of MAGP-1 with tropoelastin and fibrillin-1, we expressed human MAGP-1 as a T7-tag fusion protein in Escherichia coli.
Sacha A. Jensen, Dieter P. Reinhardt, Mark Gibson, Anthony S. Weiss   +3 more
openalex   +6 more sources

Marfan syndrome variation of the POGLUT2 and POGLUT3 consensus sequence can produce aberrant fibrillin-1 O-glucosylation. [PDF]

J Biol Chem
Kegley NR, Ito A, Williamson DB, McArdle CC, Haltiwanger RS.   +4 more
europepmc   +2 more sources