Results 131 to 140 of about 22,293 (293)

Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-Tagged Collagen Constructs [PDF]

, 2018
Type I collagen is the most abundant extracellular matrix protein in bone and other connective tissues and plays key roles in normal and pathological bone formation as well as in connective tissue disorders and fibrosis.
Bonewald, Lynda F., Dallas, Sarah L., Dusevich, Vladimir, Grillo, Michael A., Kamel-El Sayed, Suzan A., Lu, Yongbo, Phillips, Charlotte L., Tiede-Lewis, LeAnn M., Veno, Patricia A., Wang, Kun   +9 more
core   +1 more source

Proteomic analysis of liver fibrosis reveals EFEMP1 as a new modulator of focal adhesion and migration of hepatic stellate cells

The FASEB Journal, Volume 39, Issue 7, 15 April 2025.
Proteomic screening of decellularized fibrotic human liver samples identified three members of the fibulin protein family, fibulin‐2, ‐3, and ‐5, as significantly associated with fibrosis progression. More specifically, gene‐silencing studies in a hepatic stellate cell line suggest a pivotal role for fibulin‐3 in regulating focal adhesions and ...
Célia Thomas, Fidaa Bouezzedine, Dominique Bonnier, Vincent Legagneux, Nathalie Théret   +4 more
wiley   +1 more source

Project Retrosight. Understanding the returns from cardiovascular and stroke research: Case Studies [PDF]

, 2011
Copyright @ 2011 RAND Europe. All rights reserved. The full text article is available via the link below.This project explores the impacts arising from cardiovascular and stroke research funded 15-20 years ago and attempts to draw out aspects of the ...
Buxton, MJ, Grant, J, Hanney, S, Pollitt, A, Wooding, S   +4 more
core  

Extracellular Regulation of Bone Morphogenetic Protein Activity by the Microfibril Component Fibrillin-1*

Journal of Biological Chemistry, 2016
Since the discovery of bone morphogenetic proteins (BMPs) as pluripotent cytokines extractable from bone matrix, it has been speculated how targeting of BMPs to the extracellular matrix (ECM) modulates their bioavailability. Understanding these processes
Alexander P Wohl, Helen Troilo, R. Collins, C. Baldock, G. Sengle   +4 more
semanticscholar   +1 more source

Stroma gene signature predicts responsiveness to chemotherapy in pancreatic ductal adenocarcinoma patient‐derived xenograft models

Molecular Oncology, Volume 19, Issue 4, Page 1075-1091, April 2025.
Pancreatic ductal adenocarcinoma patient‐derived xenografts (PDAC‐PDXs) engrafted orthotopically in the pancreas of immunodeficient mice retain the main genetic and histopathological characteristics of the original human tumors. A 294 stroma gene signature differentiates between PDAC‐PDXs that are responsive to gemcitabine plus nab‐paclitaxel versus ...
Alessia Anastasia, Laura Formenti, Paola Ostano, Lucia Minoli, Andrea Resovi, Lavinia Morosi, Claudia Fioravanti, Edoardo Micotti, Cristina Matteo, Eugenio Scanziani, Giovanna Chiorino, Raffaella Giavazzi, Carmen Ghilardi, Dorina Belotti   +13 more
wiley   +1 more source

A comparative study of the elastic fibre system within the mouse and human cornea [PDF]

, 2018
The cornea relies on its organised extracellular matrix for maintaining transparency and biomechanical strength. Studies have identified an elastic fibre system within the human posterior cornea, thought to allow for slight deformations in response to ...
Feneck, Eleanor M., Lewis, Philip N., Meek, Keith M., Ralphs, Jim   +3 more
core   +2 more sources

De Novo Balanced Translocations Disrupting the FBN1 Gene Diagnosed by Genome Sequencing: An Uncommon Cause of Marfan Syndrome Modifying Genetic Counseling

American Journal of Medical Genetics Part A, Volume 197, Issue 4, April 2025.
ABSTRACT Marfan syndrome (MFS) is a well‐characterized rare genetic connective tissue disorder. The features of MFS are primarily skeletal, ocular, and cardiovascular and are mainly caused by single‐nucleotide variants (SNVs) in the FBN1 gene (MIM#134797) located on chromosome 15q21.1.
C. Racine, P. Callier, R. Touraine, A. Vitobello, N. Hanna, P. Arnaud, G. Jondeau, C. Boileau, C. Thauvin‐Robinet, I. Creveaux, V. Gatinois, M. Willems, L. Faivre   +12 more
wiley   +1 more source

P10.05 REDUCED MOLECULAR FLEXIBILITY IN THE LARGE ARTERIES OF DIABETIC RATS

Artery Research, 2009
In Type 1 and 2 diabetes tissue stiffening is evident from measurements of the gross mechanical properties of the vasculature. In general, pathological glycosylation of extracellular matrix proteins may play an important role in increasing stiffness in ...
R. Akhtar, N. Gardiner, J.K. Cruickshank, B. Derby, M.J. Sherratt   +4 more
doaj   +1 more source

Extracellular Matrix Molecules Facilitating Vascular Biointegration [PDF]

, 2014
All vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy.
Michael, Praveesuda, Ng, Martin K.C., Waterhouse, Anna, Wise, Steven G.   +3 more
core   +1 more source

Genome of Kumamoto Oyster Crassostrea sikamea Provides Insights Into Bivalve Evolution and Environmental Adaptation

Evolutionary Applications, Volume 18, Issue 4, April 2025.
ABSTRACT The Kumamoto oyster, Crassostrea sikamea, is a marine bivalve naturally distributed along the coasts of southern China and southern Japan, with a hatchery population that has been under domestication in the United States since its introduction from Japan in the 1940s.
Sheng Liu, Youli Liu, Ximing Guo, Naoki Itoh, Guangqiu Chang, Zhihua Lin, Qinggang Xue   +6 more
wiley   +1 more source