Results 171 to 180 of about 12,218 (212)
Proteomic analysis of fibrillin-rich microfibrils
Proteomics, 2006 Abstract MS has been used to investigate the composition of fibrillin‐rich microfibrils from non‐elastic and elastic tissues, and to compare fibrillin‐1 tryptic fingerprints derived from whole zonules, microfibrils and recombinant fibrillin‐1.
Stuart A Cain +2 more
exaly +4 more sources
Fibrillin-1 regulates the bioavailability of TGFβ1 [PDF]
Journal of Cell Biology, 2007 We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) β1, a powerful cytokine that modulates cell survival and phenotype. Altered TGFβ signaling is a major contributor to the pathology of Marfan syndrome (MFS) and related diseases.
Stuart A Cain +2 more
exaly +4 more sources
Fibrillin-1 regulates endothelial sprouting during angiogenesis
Proceedings of the National Academy of Sciences of the United States of America, 2023 Fibrillin-1 is an extracellular matrix protein that assembles into microfibrils which provide critical functions in large blood vessels and other tissues.
Florian Alonso +2 more
exaly +2 more sources
Fibrillin-3 expression in human development
Matrix Biology, 2011 Fibrillin proteins are the major components of extracellular microfibrils found in many connective tissues. Fibrillin-1 and fibrillin-2 are well studied and mutations in these proteins cause a number of fibrillinopathies including Marfan syndrome and ...
Laetitia Sabatier +2 more
exaly +2 more sources
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The International Journal of Biochemistry & Cell Biology, 1999
Fibrillins 1 and 2 are the main constituents of the extracellular microfibrils responsible for the biomechanical properties of most tissues and organs. They are cysteine-rich glycoproteins predominantly made of multiple repeats homologous to the calcium-binding epidermal growth factor module, and are translated as precursor proteins cleaved by furine ...
F, Ramirez, L, Pereira
openaire +2 more sources
Fibrillins 1 and 2 are the main constituents of the extracellular microfibrils responsible for the biomechanical properties of most tissues and organs. They are cysteine-rich glycoproteins predominantly made of multiple repeats homologous to the calcium-binding epidermal growth factor module, and are translated as precursor proteins cleaved by furine ...
F, Ramirez, L, Pereira
openaire +2 more sources
Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils [PDF]
Matrix Biology, 2011 The contribution of non-collagenous components of the extracellular matrix to bone strength is largely undefined. Here we report that deficiency of fibrillin-1 or fibrillin-2 microfibrils causes distinct changes in bone material and mechanical properties. Morphometric examination of mice with hypomorphic or null mutations in fibrillin-1 or fibrillin-2,
Emilio Arteaga-Solis +2 more
exaly +3 more sources
2018
Fibrillins are one of the major components of supramolecular fibrous structures in the extracellular matrix of elastic and nonelastic tissues, termed microfibrils. Microfibrils provide tensile strength in nonelastic tissues and scaffolds for the assembly of tropoelastin in elastic tissues, and act a regulator of growth factor bioavailability and ...
Heena, Kumra, Dieter P, Reinhardt
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Fibrillins are one of the major components of supramolecular fibrous structures in the extracellular matrix of elastic and nonelastic tissues, termed microfibrils. Microfibrils provide tensile strength in nonelastic tissues and scaffolds for the assembly of tropoelastin in elastic tissues, and act a regulator of growth factor bioavailability and ...
Heena, Kumra, Dieter P, Reinhardt
openaire +2 more sources
Immunohistochemical expression of fibrillin‐1 and fibrillin‐2 during tooth development
Journal of Periodontal Research, 2014Background and ObjectiveOxytalan fibers are categorized as a microfibril assembly without elastin deposition, and are unique components in the periodontal ligament (PDL). However, little is known about their formation during PDL development. To clarify the mechanisms of oxytalan fiber formation in developing PDL, we performed immunohistochemical ...
M, Kira-Tatsuoka +4 more
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The fibrillin‐marfan syndrome connection
BioEssays, 1993AbstractA few years ago no one would have suspected that the well‐known disorder of connective tissue, Marfan syndrome, could be caused by mutations in a recently discovered extracellular component, fibrillin. Likewise, nobody would have predicted that fibrillin represents a small family of proteins that are associated with several pheno‐typically ...
F, Ramirez, L, Pereira, H, Zhang, B, Lee
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Cell adhesion and integrin binding to recombinant human fibrillin-1
FEBS Letters, 1996 Fibrillin-1 is a major constituent of tissue microfibrils that occur in most connective tissues, either in close association with or independent of elastin.
Dieter P Reinhardt +2 more
exaly +2 more sources