Results 11 to 20 of about 22,293 (293)
Microenvironmental regulation by fibrillin-1. [PDF]
PLoS Genetics, 2012 Fibrillin-1 is a ubiquitous extracellular matrix molecule that sequesters latent growth factor complexes. A role for fibrillin-1 in specifying tissue microenvironments has not been elucidated, even though the concept that fibrillin-1 provides ...
Gerhard Sengle +14 more
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Frontiers in Aging Neuroscience, 2016 Tendons among connective tissue, mainly collagen, contain also elastic fibres made of fibrillin 1, fibrillin 2 and elastin that are broadly distributed in tendons and represent 1-2% of the dried mass of the tendon.
Betti Giusti, Guglielmina Pepe
doaj +4 more sources
The evolution of extracellular fibrillins and their functional domains.
PLoS ONE, 2012 Fibrillins constitute the major backbone of multifunctional microfibrils in elastic and non-elastic extracellular matrices, and are known to interact with several binding partners including tropoelastin and integrins.
Adam Piha-Gossack +2 more
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The role of calcium in the organization of fibrillin microfibrils [PDF]
FEBS Letters, 1993 The microfibrillar glycoprotein fibrillin has a multidomain structure which contains forty-three epidermal growth factor-like motifs with calciumbinding consensus sequences.
Kielty, Cay M., Shuttleworth, C.Adrian
core +5 more sources
The Supramolecular Organization of Fibrillin-Rich Microfibrils [PDF]
The Journal of Cell Biology, 2001 We propose a new model for the alignment of fibrillin molecules within fibrillin microfibrils. Automated electron tomography was used to generate three-dimensional microfibril reconstructions to 18.6-Å resolution, which revealed many new organizational details of untensioned microfibrils, including heart-shaped beads from which two arms emerge, and ...
Clair Baldock +7 more
openalex +6 more sources
Fibrillin-1 and fibrillin-1-derived asprosin in adipose tissue function and metabolic disorders [PDF]
Journal of Cell Communication and Signaling, 2020 The extracellular matrix microenvironment of adipose tissue is of critical importance for the differentiation, remodeling and function of adipocytes. Fibrillin-1 is one of the main components of microfibrils and a key player in this process. Furin processing of profibrillin-1 results in mature fibrillin-1 and releases the C-terminal propeptide as a ...
Muthu L. Muthu, D. Reinhardt
semanticscholar +4 more sources
Macromolecular crowding enhances fibrillin-1 deposition in the extracellular matrix [PDF]
European Cells & Materials, 2022 Biochemical and biophysical factors need consideration when modelling in vivo cellular behaviour using in vitro cell culture systems. One underappreciated factor is the high concentration of macromolecules present in vivo, which is typically not ...
B Satz-Jacobowitz +3 more
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Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development
eLife, 2022 The embryonic extracellular matrix (ECM) undergoes transition to mature ECM as development progresses, yet few mechanisms ensuring ECM proteostasis during this period are known.
Timothy J Mead +10 more
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Fibrillin-1 regulates endothelial sprouting during angiogenesis
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Mutations in the gene coding for fibrillin-1, a protein in the extracellular matrix, cause Marfan syndrome, which is characterized by pathological changes in large blood vessels. We show that fibrillin-1 regulates angiogenesis, the formation
F. Alonso +7 more
semanticscholar +1 more source
Cancer Communications, 2022 Chemotherapy resistance is a primary reason of ovarian cancer therapy failure; hence it is important to investigate the underlying mechanisms of chemotherapy resistance and develop novel potential therapeutic targets.
Ziliang Wang +11 more
semanticscholar +1 more source