Results 21 to 30 of about 12,218 (212)

Fibrillins in Adult Human Ovary and Polycystic Ovary Syndrome: Is Fibrillin-3 Affected in PCOS? [PDF]

Journal of Histochemistry & Cytochemistry, 2010
Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age. Although genetic linkage analyses have demonstrated a susceptibility locus for PCOS mapping to the fibrillin-3 gene, the presence of fibrillin proteins in normal and polycystic ovaries has not been characterized.
C Diana, Jordan, Sandra D, Bohling, Noe L, Charbonneau, Lynn Y, Sakai   +3 more
openaire   +3 more sources

Macromolecular crowding enhances fibrillin-1 deposition in the extracellular matrix [PDF]

European Cells & Materials, 2022
Biochemical and biophysical factors need consideration when modelling in vivo cellular behaviour using in vitro cell culture systems. One underappreciated factor is the high concentration of macromolecules present in vivo, which is typically not ...
B Satz-Jacobowitz, N Taye, SZ Karoulias, D Hubmacher   +3 more
doaj   +1 more source

Circulating fibrillin fragment concentrations in patients with and without aortic pathology

JVS - Vascular Science, 2022
Objective: Fragments of fibrillin-1 and fibrillin-2 will be detectable in the plasma of patients with aortic dissections and aneurysms. We sought to determine whether the plasma fibrillin fragment levels (PFFLs) differ between patients with thoracic ...
Eric J. Carlson, PhD, Megan Rushkin, BA, Derek Darby, BA, Trisha Chau, BS, Renee L. Shirley, PhD, Jeff S. King, PhD, Khanh Nguyen, MD, Gregory J. Landry, MD, Gregory L. Moneta, MD, Cherrie Abraham, MD, Lynn Y. Sakai, PhD, Amir F. Azarbal, MD   +11 more
doaj   +1 more source

Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels? [PDF]

International Neurourology Journal, 2015
Purpose: Pelvic organ prolapse is a multifactorial disorder in which extracellular matrix defects are implicated. Fibrillin-1 level is reduced in stress urinary incontinence.
Ayla Eser, Eylem Unlubilgin, Fatih Hizli, Muradiye Acar, Zeynep Kamalak, Aydin Kosus, Nermin Kosus, Deniz Hizli, Esra Gunduz   +8 more
doaj   +1 more source

Contrast-Enhanced Tissue Processing of Fibrillin-Rich Elastic Fibres for 3D Visualization by Volume Scanning Electron Microscopy

Methods and Protocols, 2021
Elastic fibres constitute an important component of the extracellular matrix and currently are the subject of intensive study in order to elucidate their assembly, function and involvement in cell–matrix interactions and disease.
Philip N. Lewis, Robert D. Young, R. B. Souza, Andrew J. Quantock, Keith M. Meek   +4 more
doaj   +1 more source

Fibrillin and the eye [PDF]

British Journal of Ophthalmology, 2000
The glycoprotein fibrillin is the principal component of the ciliary zonule and has an important role in the strength and elasticity of ocular connective tissues. Fibrillin polymers form the structural scaffold of extensible microfibrils1-3 which are present in ocular elastic tissues and are arranged in parallel bundles to form the zonular fibres.4 ...
J L, Ashworth, C M, Kielty, D, McLeod
openaire   +2 more sources

Role of fibrilins in human cancer: A narrative review

Health Science Reports, 2023
Background Fibrillin is one of the extracellular matrix glycoproteins and participates in forming microfibrils found in many connective tissues. The microfibrils enable the elasticity and stretching properties of the ligaments and support connective ...
Mahsa Mahdizadehi, Marie Saghaeian Jazi, Seyyed Mostafa Mir, Seyyed Mehdi Jafari   +3 more
doaj   +1 more source

Autosomal Recessive Cutis Laxa 1C Mutations Disrupt the Structure and Interactions of Latent TGFβ Binding Protein-4

Frontiers in Genetics, 2021
Latent TGFβ binding protein-4 (LTBP4) is a multi-domain glycoprotein, essential for regulating the extracellular bioavailability of TGFβ and assembly of elastic fibre proteins, fibrillin-1 and tropoelastin.
Yasmene F. Alanazi, Michael P. Lockhart-Cairns, Stuart A. Cain, Thomas A. Jowitt, Anthony S. Weiss, Anthony S. Weiss, Anthony S. Weiss, Clair Baldock   +7 more
doaj   +1 more source

A Pan-Transcriptome Analysis Indicates Efficient Downregulation of the FIB Genes Plays a Critical Role in the Response of Alfalfa to Cold Stress

Plants, 2022
Alfalfa (Medicago sativa L.) is a perennial forage legume that is widely distributed throughout the world, and cold stress is an important environmental factor limiting the growth and production of alfalfa in cold regions. However, little is known of the
Xueqi Zhang, Huanhuan Yang, Manman Li, Yan Bai, Chao Chen, Donglin Guo, Changhong Guo, Yongjun Shu   +7 more
doaj   +1 more source

Late spontaneous bilateral intraocular lens subluxation accompanied with intraocular pressure elevation in a patient with acromegaly

Taiwan Journal of Ophthalmology, 2020
A 53-year-old male with newly diagnosed acromegaly came to our clinic with the chief complaint of diplopia. He had the past ocular history of uneventful phacoemulsification cataract surgery with intraocular lens (IOL) implantation in the right eye 17 ...
Yin-Hsi Chang, San-Ni Chen
doaj   +1 more source