Results 201 to 210 of about 13,534 (227)
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2005
Fibrillin microfibrils are widely distributed extracellular matrix assemblies that endow elastic and nonelastic connective tissues with long-range elasticity. They direct tropoelastin deposition during elastic fibrillogenesis and form an outer mantle for mature elastic fibers.
Kielty, Cay M. +3 more
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Fibrillin microfibrils are widely distributed extracellular matrix assemblies that endow elastic and nonelastic connective tissues with long-range elasticity. They direct tropoelastin deposition during elastic fibrillogenesis and form an outer mantle for mature elastic fibers.
Kielty, Cay M. +3 more
openaire +4 more sources
Immunohistochemical expression of fibrillin‐1 and fibrillin‐2 during tooth development
Journal of Periodontal Research, 2014Background and ObjectiveOxytalan fibers are categorized as a microfibril assembly without elastin deposition, and are unique components in the periodontal ligament (PDL). However, little is known about their formation during PDL development. To clarify the mechanisms of oxytalan fiber formation in developing PDL, we performed immunohistochemical ...
Masao Ozaki +4 more
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The structure and function of fibrillin.
Ciba Foundation symposium, 1995Fibrillin is a very large molecule whose primary structure is now known from the cloning and sequencing of 10 kb of cDNA. Immunohistochemical results suggest that one of the functions of fibrillin molecules is to contribute to the structure of the microfibril.
Lynn Y. Sakai +2 more
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Fibrillin immunofluorescence in pseudoxanthoma elasticum
Journal of the American Academy of Dermatology, 1995Pseudoxanthoma elasticum (PXE) is a rare heritable connective tissue disorder manifested by skin, ocular, and cardiovascular anomalies. The basic defect is unknown; however, the microscopic findings are indicative of defects in elastic fibers. Among the components of the elastic fibers are elastin and elastin-associated microfibrils.We assessed the ...
Jason Cisler +6 more
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The fibrillin‐marfan syndrome connection
BioEssays, 1993AbstractA few years ago no one would have suspected that the well‐known disorder of connective tissue, Marfan syndrome, could be caused by mutations in a recently discovered extracellular component, fibrillin. Likewise, nobody would have predicted that fibrillin represents a small family of proteins that are associated with several pheno‐typically ...
Brendan Lee +3 more
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2010
Microfibrils are supramolecular structures ubiquitously found in the extracellular matrix of elastic and nonelastic tissues. The three members of the cysteine-rich fibrillin family constitute the core of microfibrils. Mutations in fibrillin-1 and -2 lead to a number of heritable connective tissue disorders termed fibrillinopathies.
Dieter P. Reinhardt, Dirk Hubmacher
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Microfibrils are supramolecular structures ubiquitously found in the extracellular matrix of elastic and nonelastic tissues. The three members of the cysteine-rich fibrillin family constitute the core of microfibrils. Mutations in fibrillin-1 and -2 lead to a number of heritable connective tissue disorders termed fibrillinopathies.
Dieter P. Reinhardt, Dirk Hubmacher
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Abnormalities of fibrillin in acquired cutis laxa [PDF]
Journal of the American Academy of Dermatology, 1994 Degeneration of elastic tissue in acquired cutis laxa has been previously described, but microfibrils have not been adequately studied.We determined whether the microfibrillar component of elastic tissue is affected in skin of a patient with acquired cutis laxa.Lesional skin was examined with indirect immunofluorescence and immunoelectron microscopy ...
Martin Lebwohl +5 more
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Proteomic analysis of fibrillin‐rich microfibrils
PROTEOMICS, 2006AbstractMS has been used to investigate the composition of fibrillin‐rich microfibrils from non‐elastic and elastic tissues, and to compare fibrillin‐1 tryptic fingerprints derived from whole zonules, microfibrils and recombinant fibrillin‐1. In all microfibril preparations, fibrillin‐1 was abundant and the only fibrillin isoform.
Cay M. Kielty +6 more
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Journal of Dental Research, 2002
The elastic system fibers consist of three types—oxytalan, elaunin, and elastic fibers—differing in their relative microfibril and elastin contents. All three types are found in human gingiva, but human periodontal ligaments contain only elastin-free fibers.
Toshihiko Yajima +2 more
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The elastic system fibers consist of three types—oxytalan, elaunin, and elastic fibers—differing in their relative microfibril and elastin contents. All three types are found in human gingiva, but human periodontal ligaments contain only elastin-free fibers.
Toshihiko Yajima +2 more
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Biochemical Journal, 2016
The 10-12 nm diameter microfibrils of the extracellular matrix (ECM) impart both structural and regulatory properties to load-bearing connective tissues.
S. Jensen, P. Handford
semanticscholar +1 more source
The 10-12 nm diameter microfibrils of the extracellular matrix (ECM) impart both structural and regulatory properties to load-bearing connective tissues.
S. Jensen, P. Handford
semanticscholar +1 more source