Results 41 to 50 of about 7,077 (251)

Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights into Microfibril Organization [PDF]

, 2004
Human fibrillin-1, the major structural protein of extracellular matrix (ECM) 10–12 nm microfibrils, is dominated by 43 calcium binding epidermal growth factor-like (cbEGF) and 7 transforming growth factor β binding protein-like (TB) domains.
Altroff, Altroff, Arnaout, Baldock, Bax, Brunger, Cardy, CCP4, Chobotova, Colman, Dallas, de La Fortelle, Dietz, Downing, Eriksen, Esnouf, Fowler, Garcia, Gibson, Gibson, Giltay, Gouet, Handford, Harlos, Hotchin, Irie, Isogai, Jensen, Kabsch, Kanzaki, Kettle, Kielty, Knott, Krawczak, Laskowski, Lawrence, Lin, Lin, Logan, Mardon, McGettrick, Merritt, Moren, Mould, Obara, Oberhauser, Otwinowski, Pereira, Pfaff, Qian, Rao, Reinhardt, Reinhardt, Reinhardt, Saharinen, Sakai, Sakai, Sakamoto, Sheldrick, Sherratt, Sherratt, Stuart, Taipale, Takagi, Thompson, Trask, Werner, Wess, Xiong, Xiong, Yin, Yuan, Yuan, Zhang, Zhang   +74 more
core   +3 more sources

Targeting of Bone Morphogenetic Protein Growth Factor Complexes to Fibrillin [PDF]

Journal of Biological Chemistry, 2008
Both latent transforming growth factor-β (TGF-β)-binding proteins fibrillins are components of microfibril networks, and both interact with members of the TGF-β family of growth factors.
Gerhard Sengle, Noé L. Charbonneau, Robert N. Ono, Takako Sasaki, Jennifer Alvarez, Douglas R. Keene, Hans Peter Bächinger, Lynn Y. Sakai   +7 more
openalex   +2 more sources

LTBP4 in Health and Disease

Genes, 2021
Latent transforming growth factor β (TGFβ)-binding protein (LTBP) 4, a member of the LTBP family, shows structural homology with fibrillins. Both these protein types are characterized by calcium-binding epidermal growth factor-like repeats interspersed ...
Chi-Ting Su, Z. Urban
semanticscholar   +1 more source

Microenvironmental Regulation by Fibrillin-1

PLoS Genetics, 2012
Fibrillin-1 is a ubiquitous extracellular matrix molecule that sequesters latent growth factor complexes. A role for fibrillin-1 in specifying tissue microenvironments has not been elucidated, even though the concept that fibrillin-1 provides extracellular control of growth factor signaling is currently appreciated.
Eric J. Carlson, Eric J. Carlson, Kiyotoshi Sekiguchi, Susan J. Hayflick, Gerhard Sengle, Gerhard Sengle, Takako Sasaki, Takako Sasaki, Sara F. Tufa, Lynn Y. Sakai, Lynn Y. Sakai, Ko Tsutsui, Ko Tsutsui, Ko Tsutsui, Robert N. Ono, Douglas R. Keene, Mary K. Wirtz, John R. Samples, Liselotte I. Fessler, John H. Fessler, Noe L. Charbonneau   +20 more
openaire   +6 more sources

A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation. [PDF]

, 1996
Mice carrying the Tight skin (Tsk) mutation have thickened skin and visceral fibrosis resulting from an accumulation of extracellular matrix molecules.
Buchberg, Arthur M., Christner, Paul J., Jimenez, Sergio A., Ma, Qing, Manne, Jayanthi, McGrath, Rodney, Moskow, John J., Siracusa, Linda D.   +7 more
core   +3 more sources

The role of the stromal extracellular matrix in the development of pterygium pathology: an update [PDF]

, 2021
22 p.Pterygium is a benign fibrovascular lesion of the bulbar conjunctiva with frequent involvement of the corneal limbus. Its pathogenesis has been mainly attributed to sun exposure to ultraviolet-B radiation.
Benito Martínez, Selma, Buján Varela, María Julia Araceli, Martín López, Javier, Pascual González, María Gemma, Pérez Köhler, Bárbara, Pérez Rico, María Consuelo   +5 more
core   +1 more source

Fibrillins, fibulins, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide.

Biochemistry, 2008
Elastin is the polymeric protein responsible for the properties of extensibility and elastic recoil of the extracellular matrix in a variety of tissues.
J. Cirulis, C. Bellingham, E. Davis, D. Hubmacher, D. Reinhardt, R. Mecham, F. Keeley   +6 more
semanticscholar   +1 more source

Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts

Scientific Reports, 2017
Tissue microenvironments formed by extracellular matrix networks play an important role in regulating tissue structure and function. Extracellular microfibrillar networks composed of fibrillins and their associated ligands such as LTBPs, fibulins, and ...
Alvise Schiavinato, Douglas R. Keene, Thomas Imhof, Roberto Doliana, Takako Sasaki, Gerhard Sengle   +5 more
doaj   +1 more source

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development

Matrix Biology, 2002
The extracellular glycoproteins fibrillin-1 and fibrillin-2 are major components of connective tissue microfibrils. Mutations in the fibrillin-1 and fibrillin-2 genes are responsible for the phenotypical manifestations of Marfan syndrome and congenital contractural arachnodactyly respectively, which emphasizes their essential roles in developmental ...
Quondamatteo, Fabio, Reinhardt, D. P., Charbonneau, N. L., Pophal, G., Sakai, L. Y., Herken, R.   +5 more
openaire   +4 more sources

Arabidopsis fibrillin 1-2 subfamily members exert their functions via specific protein–protein interactions

Journal of Experimental Botany, 2021
Fibrillins (FBNs) are plastidial proteins found in photosynthetic organisms from cyanobacteria to higher plants. The function of most FBNs remains unknown. Here, we focused on members of the FBN subgroup comprising FBN1a, FBN1b, and FBN2.
Diego Torres-Romero, Ángeles Gómez-Zambrano, A. Serrato, M. Sahrawy, Á. Mérida   +4 more
semanticscholar   +1 more source