Results 71 to 80 of about 2,560 (174)

A Chemical Probe for Increasing Leaf Tocopherol Levels by Coordinated Modulation of Biosynthesis, Competition and Storage

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant biofortification with phytonutrients typically relies on metabolic engineering strategies known as ‘push’ (enhancing biosynthetic flux), ‘block’ (inhibiting competing pathways) and ‘pull’ (promoting metabolite storage). Here, we describe a novel synthetic compound, X57, that simultaneously targets biosynthesis, competition and storage to
Pablo Perez‐Colao, Gaetan Glauser, Jacobo Cruces, Jorge Lozano‐Juste, Manuel Rodriguez‐Concepcion   +4 more
wiley   +1 more source

Subtle balance of tropoelastin molecular shape and flexibility regulates dynamics and hierarchical assembly [PDF]

, 2015
The assembly of the tropoelastin monomer into elastin is vital for conferring elasticity on blood vessels, skin, and lungs. Tropoelastin has dual needs for flexibility and structure in self-assembly.
Baldock, Clair, Buehler, Markus J, Tarakanova, Anna, Weiss, Anthony S., Wise, Steven G., Yeo, Giselle C.   +5 more
core   +1 more source

Tobamoviruses CP Proteins Hijack Light‐Induced Protein (NbLIP1) to Promote Viral Replication by Facilitating VRO Formation

Plant Biotechnology Journal, EarlyView.
ABSTRACT Tobamoviruses establish viral replication organelles (VROs) on the host endoplasmic reticulum (ER) for their replication, a process demanding substantial different types of lipids. However, how viruses efficiently transfer these lipids from other compartments like chloroplasts remains incompletely understood.
Haoyu Chen, Mingjie Wu, Xiao Guo, Hongmei Xu, Chenwei Feng, Duxuan Liu, Jing Hua, Yanhong Hua, Zhen He, Peter Moffett, Kun Zhang   +10 more
wiley   +1 more source

Plastid lipid droplets at the crossroads of prenylquinone metabolism [PDF]

, 2017
Lipid droplets called plastoglobules (PGs) exist in most plant tissues and plastid types. In chloroplasts, the polar lipid monolayer surrounding these low-density lipoprotein particles is continuous with the outer lipid leaflet of the thylakoid membrane.
Abraham, Marion, Besagni, Céline, Dörmann, Peter, Eugeni Piller, Lucia, Kessler, Felix   +4 more
core  

Bronchopulmonary dysplasia - an overview about pathophysiologic concepts [PDF]

, 2015
Neonatal chronic lung disease in the preterm infant, i.e. bronchopulmonary dysplasia (BPD) is characterized by impaired pulmonary development with its effects persisting into adulthood.
Anne Hilgendorff, Sophie Niedermaier
core   +1 more source

Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren's disease

The Journal of Pathology, Volume 268, Issue 4, Page 383-397, April 2026.
Abstract Dupuytren's disease is a fibroproliferative disorder of the palmer fascia (PF) characterised by flexion contractures in the hand. Dupuytren's disease can be treated surgically, but disease recurrence rates are high, potentially due to continual production of matrisomal proteins.
Gabriella Cooper, Jade A Gumbs, Sahem Alkharabsheh, Katie J Lee, Alan Carter, Hannah Coleman, Niamh S O'Heneghan‐Yates, Rama Ijaz, Emma Beamish, Lisa A Menezes, Triantafillos Liloglou, Peter D Clegg, Elizabeth G. Canty‐Laird   +12 more
wiley   +1 more source

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils [PDF]

Matrix Biology, 2011
The contribution of non-collagenous components of the extracellular matrix to bone strength is largely undefined. Here we report that deficiency of fibrillin-1 or fibrillin-2 microfibrils causes distinct changes in bone material and mechanical properties. Morphometric examination of mice with hypomorphic or null mutations in fibrillin-1 or fibrillin-2,
Emilio, Arteaga-Solis, Lee, Sui-Arteaga, Minwook, Kim, Mitchell B, Schaffler, Karl J, Jepsen, Nancy, Pleshko, Francesco, Ramirez   +6 more
openaire   +2 more sources

DPY-17 and MUA-3 Interact for Connective Tissue-Like Tissue Integrity in Caenorhabditis elegans: A Model for Marfan Syndrome [PDF]

, 2015
mua-3 is a Caenorhabditis elegans homolog of the mammalian fibrillin1, a monogenic cause of Marfan syndrome. We identified a new mutation of mua-3that carries an in-frame deletion of 131 amino acids in the extracellular domain, which allows the mutants ...
Fotopoulos, Pauline, Hyun, Moonjung, Kim, Jeongho, Lee, Inhwan, Qamari, Waiss, You, Young-Jai   +5 more
core   +5 more sources

ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish. [PDF]

, 2013
ATF6α and ATF6β are membrane-bound transcription factors activated by regulated intramembrane proteolysis in response to endoplasmic reticulum (ER) stress to induce various ER quality control proteins.
Ishikawa, Tokiro, Ishikawa-Fujiwara, Tomoko, Kamei, Yasuhiro, Mori, Kazutoshi, Morishita, Shinichi, Okada, Tetsuya, Saito, Taro L, Sakaki, Yoshiyuki, Shigenobu, Shuji, Takeda, Shunichi, Tanaka, Minoru, Taniguchi, Yoshihito, Todo, Takeshi, Toyoda, Atsushi, Yoshimura, Jun   +14 more
core   +1 more source

Biomolecular Changes Upon Ablative Laser Therapy of the Skin: A Scoping Review

International Journal of Dermatology, Volume 65, Issue 4, Page 753-762, April 2026.
(Fractional) ablative laser therapy results in a wound healing response characterized by an inflammatory phase, dermal matrix degradation, and remodeling, collagenesis and elastogenesis. This is characterized by an increase in metalloproteinases, collagen type I, III, VII, and tropoelastin.
Marie‐Eline Pauline Henriette Debeuf, Maartje Hendrika Pieternel Rauwenhoff, Michel van Geel, Peter Martin Steijlen, Valerie Lydie Roland Marc Verstraeten   +4 more
wiley   +1 more source