Results 21 to 30 of about 200,520 (286)
Nanomaterials, 2020 Protein fibrils characterized with a cross-β-sheet quaternary structure have gained interest as nanomaterials in biomedicine, including in the design of subunit vaccines.
Soultan Al-Halifa +5 more
doaj +1 more source
Polymorphic Aβ42 fibrils adopt similar secondary structure but differ in cross-strand side chain stacking interactions within the same β-sheet. [PDF]
, 2020 Formation of polymorphic amyloid fibrils is a common feature in neurodegenerative diseases involving protein aggregation. In Alzheimer's disease, different fibril structures may be associated with different clinical sub-types.
Duo, Lan +5 more
core +1 more source
On the tear resistance of skin. [PDF]
, 2015 Tear resistance is of vital importance in the various functions of skin, especially protection from predatorial attack. Here, we mechanistically quantify the extreme tear resistance of skin and identify the underlying structural features, which lead to ...
Gludovatz, Bernd +6 more
core +2 more sources
The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils
Viruses, 2021 Cytoplasmic aggregation of the primarily nuclear TAR DNA-binding protein 43 (TDP-43) affects neurons in most amyotrophic lateral sclerosis (ALS) and approximately half of frontotemporal lobar degeneration (FTLD) cases.
Carlo Scialò +8 more
doaj +1 more source
Mimiviruses Interfere With IκBα Degradation
Frontiers in Virology, 2022 Many aspects of giant viruses biology still eludes scientists, with viruses such as Acanthamoeba polyphaga mimivirus (APMV) and Tupanvirus (TPV) possessing large virions covered by fibrils and are cultivated in laboratories using Acanthamoeba cells as ...
Juliana dos Santos Oliveira +10 more
doaj +1 more source
MoleculesA recent analysis compared the proteome of (i) blood clots seen in two diseases—sepsis and long COVID—when blood was known to have clotted into an amyloid microclot form (as judged by staining with the fluorogenic amyloid stain thioflavin T) with (ii ...
Douglas B. Kell, Etheresia Pretorius
doaj +1 more source
Impact of Aβ40 and Aβ42 Fibrils on the Transcriptome of Primary Astrocytes and Microglia
Biomedicines, 2022 Fibrillar amyloid β-protein (Aβ) deposits in the brain, which are primarily composed of Aβ40 or Aβ42 peptides, are key pathological features of Alzheimer’s disease (AD) and related disorders. Although the underlying mechanisms are still not clear, the Aβ
Xiaoyue Zhu +4 more
doaj +1 more source
Co-populated Conformational Ensembles of β(2)-Microglobulin Uncovered Quantitatively by Electrospray Ionization Mass Spectrometry [PDF]
, 2004 Ordered assembly of monomeric human β(2)-microglobulin (β(2)m) into amyloid fibrils is associated with the disorder hemodialysis-related amyloidosis. Previously, we have shown that under acidic conditions (pH
Bjorkman +46 more
core +1 more source
Extracellular Alpha-Synuclein: Mechanisms for Glial Cell Internalization and Activation
Biomolecules, 2022 Alpha-synuclein (α-syn) is a small protein composed of 140 amino acids and belongs to the group of intrinsically disordered proteins. It is a soluble protein that is highly expressed in neurons and expressed at low levels in glial cells.
Cecilia Chavarría +2 more
doaj +1 more source
Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix [PDF]
, 2015 Despite the crucial role of extracellular matrix (ECM) in directing cell fate in healthy and diseased tissues--particularly in development, wound healing, tissue regeneration and cancer--the mechanisms that direct the assembly and regulate hierarchical ...
Gourdon, Delphine +7 more
core +2 more sources