Results 11 to 20 of about 202,201 (346)
Fibrillation of transferrin [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012 The nature of fibrillar deposits from aqueous solutions of human serum and recombinant human transferrin on mica and carbon-coated formvar surfaces has been investigated.Atomic force microscopy showed that the deposition of recombinant transferrin onto the hydrophilic surface of mica resulted in the formation of a monolayer-thick film composed of ...
C. Booyjzsen +6 more
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Prognostications of Fibrillations [PDF]
Stroke, 2015 See related article, p 1210. Post-hospital evaluation for the cause of ischemic stroke has gained increased attention in the last decade, particularly the search for paroxysmal atrial fibrillation. Initial studies of Holter monitoring documented rates of atrial fibrillation of ≈5% or 1 in 20 patients.1 Further, prolonged monitoring for as long as 1 ...
Silver, Brian, Windecker, Stephan
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Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice
Nature Neuroscience, 2020 Parkinson’s disease is a synucleinopathy that is characterized by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates.
C. Challis +8 more
semanticscholar +1 more source
Nursing Standard, 2016 Atrial fibrillation (AF) is the most common sustained cardiac rhythm disorder, and increases in prevalence with increasing age and the number of cardiovascular comorbidities. AF is characterized by a rapid and irregular heartbeat that can be asymptomatic or lead to symptoms such as palpitations, dyspnoea and dizziness.
Lip, Gregory +10 more
+13 more sources
Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
Frontiers in Molecular Neuroscience, 2019 Parkinson’s disease (PD) is one of the most common neurodegenerative disorders with a global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both the sporadic and familial forms of the disease.
Carroll Rutherford Fields +2 more
doaj +1 more source
Extracellular matrix: not just pretty fibrils
Science, 2009 Extracellular matrix (ECM) has many effects beyond providing structural support. ECM proteins typically comprise multiple, independently folded domains whose sequences and arrangement are highly conserved.
R. Hynes
semanticscholar +1 more source
2.7 Å cryo-EM structure of ex vivo RML prion fibrils
Nature Communications, 2021 Mammalian prions propagate as distinct strains and are composed of multichain assemblies of misfolded host-encoded prion protein (PrP). Here, we present a near-atomic resolution cryo-EM structure of PrP fibrils present in highly infectious prion rod ...
S. Manka +7 more
semanticscholar +1 more source
The utiquity and many roles of exopolymers (EPS) in aquatic systems
Scientia Marina, 2004 Exopolymers (EPS) are produced by unicellular and multicellular organisms. They consist largely of polysaccharides that hydrate rapidly on contact with water and link to form gels.
Roger S. Wotton
doaj +1 more source
Analysis of Toxic Amyloid Fibril Interactions at Natively Derived Membranes by Ellipsometry [PDF]
, 2015 There is an ongoing debate regarding the culprits of cytotoxicity associated with amyloid disorders. Although small pre-fibrillar amyloid oligomers have been implicated as the primary toxic species, the fibrillar amyloid material itself can also induce ...
Smith, Rachel A. S. +24 more
core +2 more sources
Fibril Breaking Accelerates α-Synuclein Fibrillization [PDF]
The Journal of Physical Chemistry B, 2015 The formation of amyloid fibrils of α-synuclein (αSyn), the key protein in Parkinson's disease, is an autocatalytic process that is seeded by mature αSyn fibrils. Based on systematic measurements of the dependence of the fibril growth rate on the concentrations of monomers and preformed fibrillar seeds, we propose a mechanism of αSyn aggregation that ...
Shvadchak, Volodymyr V. +2 more
openaire +4 more sources