Results 21 to 30 of about 202,201 (346)

Harnessing the Activation of Toll-Like Receptor 2/6 by Self-Assembled Cross-β Fibrils to Design Adjuvanted Nanovaccines

Nanomaterials, 2020
Protein fibrils characterized with a cross-β-sheet quaternary structure have gained interest as nanomaterials in biomedicine, including in the design of subunit vaccines.
Soultan Al-Halifa, Ximena Zottig, Margaryta Babych, Mélanie Côté-Cyr, Steve Bourgault, Denis Archambault   +5 more
doaj   +1 more source

Fibril fragmentation in amyloid assembly and cytotoxicity: When size matters [PDF]

, 2010
Amyloid assemblies are associated with several debilitating human disorders. Understanding the intra- and extracellular assembly of normally soluble proteins and peptides into amyloid aggregates and how they disrupt normal cellular functions is therefore
Xue, Wei-Feng, Hellewell, Andrew L., Hewitt, Eric W., Radford, Sheena E., Eric W. Hewitt, Andrew L. Hellewell, Wei-Feng Xue, Sheena E. Radford   +7 more
core   +1 more source

Assessment of Aggregated and Exosome-Associated α-Synuclein in Brain Tissue and Cerebrospinal Fluid Using Specific Immunoassays

Diagnostics, 2023
Even though it is currently well-established that α-synuclein aggregation is closely associated with the pathological events in Parkinson’s disease (PD) and several other neurodegenerative disorders, collectively called synucleinopathies, the mechanistic
Dimitrios Anagnostou, Garifalia Sfakianaki, Katerina Melachroinou, Miltiadis Soutos, Vassilios Constantinides, Nishant Vaikath, Ioanna Tsantzali, George P. Paraskevas, Omar El Agnaf, Kostas Vekrellis, Evangelia Emmanouilidou   +10 more
doaj   +1 more source

Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K. [PDF]

, 2013
PMCID: PMC3591419This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
Chad M Rienstra, Julia M. George (386756), Rikardsen, LK, Shin W Lee, Lars K. Rikardsen (386754), Gemma Comellas, Luisel R. Lemkau, Shin W. Lee (386753), Lars K Rikardsen, Rienstra Chad M., Lee, SW, Lee Shin W., Woods, WS, Lemkau, LR, Julia M. George, Luisel R. Lemkau (386752), Comellas, G, George, JM, Rikardsen Lars K., Wendy S. Woods (386755), Wendy S Woods, Woods Wendy S., Chad M. Rienstra, George Julia M., Shin W. Lee, Rienstra, CM, Lars K. Rikardsen, Chad M. Rienstra (386757), Luisel R Lemkau, Julia M George, Wendy S. Woods, Lemkau Luisel R., Comellas Gemma, Gemma Comellas (371865)   +33 more
core   +2 more sources

Is This Atrial Fibrillation? [PDF]

Annals of Noninvasive Electrocardiology, 2009
A 19‐year‐old girl was referred to our cardiology department for catheter ablation (isolation of the pulmonary veins) of paroxysmal atrial fibrillation (AF). The diagnosis was made upon a 12‐lead ECG of the arrhythmia documented in the emergency room. The ECG showed an irregular tachycardia without wide QRS complexes.
Jadidi, Amir S., Sunthorn, Henri, Burri, Haran Kumar, Gentil-Baron, Pascale, Shah, Dipen   +4 more
openaire   +3 more sources

Atrial Fibrillation [PDF]

Heart Lung <html_ent glyph="@amp;" ascii="&amp;"/> Circulation, 2003
Atrial fibrillation (AF) is a hetrogeneous disease that may present in many forms. Advances in our understanding of the mechanism responsible for AF have led to exciting new therapies that may soon provide a definitive cure.
openaire   +4 more sources

β-microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH [PDF]

, 2014
Although the molecular mechanisms underlying the pathology of amyloidoses are not well understood, the interaction between amyloid proteins and cell membranes is thought to play a role in several amyloid diseases. Amyloid fibrils of β-microglobulin (βm),
Eric W. Hewitt, Xue, W-F, Beales Paul A., Sheynis, T, Radford, SE, Neil A. Ranson (610030), Sheena E. Radford (197775), Beales, Paul A, Goodchild Sophia C., Thompson, Rebecca, Xue Wei-Feng, Neil A. Ranson, Thompson Rebecca, Sheena E Radford, Sophia C. Goodchild, Sheynis Tania, Eric W Hewitt, Kevin W. Tipping (610028), Radford Sheena E., Tipping Kevin W., Sheena E. Radford, Hewitt, EW, Xue, Wei-Feng, Beales, PA, Radford, Sheena E, Tipping, KW, Sophia C Goodchild, Paul A Beales, Goodchild, SC, Ranson, Neil A, Rebecca Thompson, Wei-Feng Xue (610029), Ranson Neil A., Neil A Ranson, Tipping, Kevin W, Tania Sheynis (610026), Kevin W Tipping, Tania Sheynis, Sheynis, Tania, Wei-Feng Xue, Goodchild, Sophia C, Eric W. Hewitt (197779), Hewitt, Eric W, Hewitt Eric W., Sophia C. Goodchild (283440), Ranson, NA, Rebecca Thompson (610027), Paul A. Beales (435545), Thompson, R, Paul A. Beales   +49 more
core   +1 more source

Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment

Frontiers in Neuroscience, 2023
Accumulation of TMEM106B fibrils composed of cleaved C-terminal fragments (CTF) of transmembrane protein 106B (TMEM106B) has recently been observed in the brains of elderly subjects and individuals with neurodegenerative diseases.
Ruoyi Ishikawa, Yu Yamazaki, Masahiro Nakamori, Tetsuya Takahashi, Hirofumi Maruyama   +4 more
doaj   +1 more source

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

Nature Communications, 2019
The formation of Aβ amyloid fibrils is a neuropathological hallmark of Alzheimer’s disease and cerebral amyloid angiopathy. However, the structure of Aβ amyloid fibrils from brain tissue is poorly understood. Here we report the purification of Aβ amyloid
M. Kollmer, William L. Close, L. Funk, Jay Rasmussen, Aref Bsoul, A. Schierhorn, Matthias Schmidt, C. Sigurdson, M. Jucker, M. Fändrich   +9 more
semanticscholar   +1 more source

Atrial Fibrillation Degenerates Into Ventricular Fibrillation

Journal of the American College of Cardiology, 2010
![Figure][1] A 43-year-old man with paroxysmal atrial fibrillation (AF) and an implantable cardioverter defibrillator (ICD) placed for documented ventricular fibrillation (VF), presented with an ICD shock. Ventricular pre-excitation was not present.
Venkataraman, Ganesh, Strickberger, S. Adam   +1 more
openaire   +2 more sources