Results 41 to 50 of about 200,520 (286)

Prion Amyloid Polymorphs – The Tag Might Change It All

Frontiers in Molecular Biosciences, 2020
Sup35p is a protein from Saccharomyces cerevisiae. It can propagate using a prion-like mechanism, which means that it can recruit non-prion soluble Sup35p into insoluble fibrils.
Luc Bousset, Nina Luckgei, Mehdi Kabani, Carole Gardiennet, Anne K. Schütz, Ronald Melki, Beat H. Meier, Anja Böckmann   +7 more
doaj   +1 more source

Anisotropic microsphere-based approach to damage in soft fibered tissue [PDF]

, 2012
The final publication is available at Springer via http://dx.doi.org/10.1007/s10237-011-0336-9An anisotropic damage model for soft fibered tissue is presented in this paper, using a multi-scale scheme and focusing on the directionally dependent behavior ...
Alastrué, V., Doblaré, Manuel, Martínez, Miguel Ángel, Pena, Estefania, Sáez Viñas, Pablo   +4 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Transgenic Tobacco as a Bioreactor for the Production of Bioactive and Triple-Helical Recombinant Type III Collagen

Plants
Collagen is the primary protein in the extracellular matrix of human cells and the body and is essential for cell structure and function. Here, for the first time, we report a method for producing recombinant triple-helical collagen type III (rhCOL3) in ...
Tairu Wu, Weisong Pan, Jiahao Pan, Yahui Wu, Wai Chin Li, Eric Po Keung Tsang, Chuan Wu   +6 more
doaj   +1 more source

Bright fibrils in Ca II K

, 2009
Context: Except for the Ca II resonance lines, fibrils are ubiquitously present in most high-resolution observations of chromospheric lines. Aims: We show that fibrils are also a prevailing feature in Ca II K, provided the spatial-resolution is ...
A. Pietarila, Ayres, Beckers, Bel, Bianda, Carlsson, Carlsson, Cauzzi, Centeno, Cheung, de Boer, de Pontieu, Fontenla, Hansteen, Holzreuter, J. Hirzberger, Janssen, Jefferies, Jones, Lagg, Marsh, McIntosh, Patsourakos, Puschmann, Rutten, Rybicki, Rybicki, S. K. Solanki, Schrijver, Selwa, Smith, Solanki, Solanki, Solanki, Title, Tritschler, Uchida, Uitenbroek, V. Zakharov, van Noort, Vecchio, Vecchio, Veeder, Weigelt, Withbroe, Wöger, Zirin   +46 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Dependence of Self-Assembled Peptide Hydrogel Network Structure on Local Fibril Nanostructure [PDF]

, 2009
Physically cross-linked, fibrillar hydrogel networks are formed by the self-assembly of β-hairpin peptide molecules with varying degrees of strand asymmetry.
Hammouda, Boualem, Hule, Rohan A., Nagarkar, Radhika P., Pochan, Darrin J., Schneider, Joel P.   +4 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Revealing Accessibility of Cryptic Protein Binding Sites within the Functional Collagen Fibril

Biomolecules, 2017
Fibrillar collagens are the most abundant proteins in the extracellular matrix. Not only do they provide structural integrity to all of the connective tissues in the human body, but also their interactions with multiple cell receptors and other matrix ...
Cody L. Hoop, Jie Zhu, Ana Monica Nunes, David A. Case, Jean Baum   +4 more
doaj   +1 more source

Limited proteolysis in the investigation of beta2-microglobulin amyloidogenic and fibrillar states. [PDF]

, 2005
Amyloid fibrils of patients treated with regular haemodialysis essentially consists of β2-microglobulin (β2-m) and its truncated species ΔN6β2-m lacking six residues at the amino terminus.
AMORESANO, ANGELA, BELLOTTI V, GIORGETTI S, MONTI, MARIA, PUCCI, PIETRO   +4 more
core   +1 more source