Results 61 to 70 of about 200,520 (286)

Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling

Cells, 2021
The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate assembly of the ECM protein, fibronectin (FN).
Caleb J. Dalton, Christopher A. Lemmon
doaj   +1 more source

Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation. [PDF]

, 2019
Alzheimer's disease (AD) pathology is characterized by the aggregation of beta-amyloid (Aβ) and tau in the form of amyloid plaques and neurofibrillary tangles in the brain.
Bitan, Gal, Di, Jing, Jiang, Lin, Li, Binsen, Murray, Kevin A, Shin, Woo Shik, Sun, Chuanqi   +6 more
core  

Chromosome Centromeres: Structural and Analytical Investigations with High Resolution Scanning Electron Microscopy in Combination with Focused Ion Beam Milling [PDF]

, 2009
Whole mount mitotic metaphase chromosomes of different plants and animals were investigated with high resolution field emission scanning electron microscopy (FESEM) to study the ultrastructural organization of centromeres, including metacentric ...
Schroeder-Reiter, E., Wanner, Gerhard
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Chromospheric observations and magnetic configuration of a supergranular structure

, 2018
Unipolar magnetic regions are often associated with supergranular cells. The chromosphere above these regions is regulated by the magnetic field, but the field structure is poorly known.
Leenaarts, Jorrit, Pozuelo, Sara Esteban, Robustini, Carolina, Rodrìguez, Jaime de la Cruz   +3 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils

Nature Communications, 2021
Systemic AA amyloidosis is a protein misfolding disease caused by the formation of amyloid fibrils from serum amyloid A (SAA) protein. Here, the authors present the cryo-EM structures of AA amyloid fibrils isolated from mouse tissue and in vitro formed ...
Akanksha Bansal, Matthias Schmidt, Matthies Rennegarbe, Christian Haupt, Falk Liberta, Sabrina Stecher, Ioana Puscalau-Girtu, Alexander Biedermann, Marcus Fändrich   +8 more
doaj   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Ca2+-Induced Cold-Set Gelation of Whey Protein Isolate Fibrils

Applied Rheology, 2006
In this paper we describe the rheological behaviour of Ca2+-induced cold-set gels of whey protein mixtures. Cold- set gels are important applications for products with a low thermal stability.
Bolder Suzanne G., Hendrickx Hanneke, Sagis Leonard M.C., van der Linden Erik   +3 more
doaj   +1 more source

Spectropolarimetric observations of an arch filament system with the GREGOR solar telescope

, 2016
Arch filament systems occur in active sunspot groups, where a fibril structure connects areas of opposite magnetic polarity, in contrast to active region filaments that follow the polarity inversion line.
Balthasar, H., Berkefeld, T., Denker, C., Feller, A., Gömöry, P., Hofmann, A., Kavka, J., Kuckein, C., Kučera, A., Lagg, A., Manrique, S. J. González, Nicklas, H., Rezaei, R., Schlichenmaier, R., Schmidt, D., Schmidt, W., Schwartz, P., Sigwarth, M., Sobotka, M., Solanki, S. K., Soltau, D., Staude, J., Strassmeier, K. G., Suárez, D. Orozco, Vašková, R., Vera, M. Collados, Volkmer, R., von der Lühe, O., Waldmann, T., Yabar, A. Pastor   +29 more
core   +1 more source