Results 71 to 80 of about 202,201 (346)

Disintegration of Amyloid fibrils using chaperones, inorganic chemicals

, 2023
Protein aggregation in the form of amyloid has been implicated in more than 50 human diseases. These diseases range from neuropathic, like Alzheimer's and Parkinson's, to common diseases like cataracts. The number of people getting affected by amyloid is
Bedsole, Sidney Ethan, NC DOCKS at East Carolina University   +1 more
core  

Self-Assembly of Amyloid Fibrils That Display Active Enzymes. [PDF]

, 2014
Enzyme immobilization is an important strategy to enhance the stability and recoverability of enzymes and to facilitate the separation of enzymes from reaction products.
Smith, Andrew T, Perrett, Sarah, Knowles, Tuomas PJ, Zhang, Hong, Sawyer, Elizabeth B, Entwistle, Aiman, Jackson, Antony P, Zhou, Xiao-Ming, Mason, Thomas O, Shimanovich, Ulyana, Mason, T.O., Jackson, A.P., Shimanovich, U., Zhang, H., Zhou, X.-M., Entwistle, A., Perrett, S., Knowles, T.P.J., Sawyer, E.B., Smith, A.T.   +19 more
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Additive Manufacturing of Prostheses Using Forest-Based Composites

Bioengineering, 2020
A custom-made prosthetic product is unique for each patient. Fossil-based thermoplastics are the dominant raw materials in both prosthetic and industrial applications; there is a general demand for reducing their use and replacing them with renewable ...
Erik Stenvall, Göran Flodberg, Henrik Pettersson, Kennet Hellberg, Liselotte Hermansson, Martin Wallin, Li Yang   +6 more
doaj   +1 more source

Proteostasis Response to Protein Misfolding in Controlled Hypertension

Cells, 2022
Hypertension is the most determinant risk factor for cardiovascular diseases. Early intervention and future therapies targeting hypertension mechanisms may improve the quality of life and clinical outcomes.
Manuel Teixeira, Dário Trindade, Marisol Gouveia, Roberta Eller-Borges, Sandra Magalhães, Ana Duarte, Miriam Ferreira, Maria I. Simões, Maria Conceição, Alexandra Nunes, Ana Gabriela Henriques, Fernando Ribeiro, Sandra I. Vieira   +12 more
doaj   +1 more source

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

Journal of the American Chemical Society, 2016
Amyloid-β (Aβ) is a 39–42 residue protein produced by the cleavage of the amyloid precursor protein (APP), which subsequently aggregates to form cross-β amyloid fibrils that are a hallmark of Alzheimer’s disease (AD).
Michael T. Colvin, R. Silvers, Qing-Zhe Ni, T. V. Can, I. Sergeyev, M. Rosay, K. Donovan, Brian Michael, J. Wall, S. Linse, R. Griffin   +10 more
semanticscholar   +1 more source

Vibrational characteristics of polymorphic hIAPP fibrils.

, 2014
(a) Mode indices for the deformation modes of hIAPP fibrils. (b) Natural frequencies of polymorphic hIAPP fibrils at a given deformation mode. (c) Contribution of each deformation mode to the thermal fluctuation of polymorphic hIAPP fibrils.
Sungsoo Na (262181), Myeongsang Lee (523341), Jae In Kim (523342), Gwonchan Yoon (523340), Kilho Eom (262191)   +4 more
core   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Orientation Matters: Polarization Dependent IR Spectroscopy of Collagen from Intact Tendon Down to the Single Fibril Level

Molecules, 2020
Infrared (IR) spectroscopy has been used for decades to study collagen in mammalian tissues. While many changes in the spectral profiles appear under polarized IR light, the absorption bands are naturally broad because of tissue heterogeneity.
Gorkem Bakir, Benoit E. Girouard, Richard Wiens, Stefan Mastel, Eoghan Dillon, Mustafa Kansiz, Kathleen M. Gough   +6 more
doaj   +1 more source

Tau and Membranes: Interactions That Promote Folding and Condensation

Frontiers in Cell and Developmental Biology, 2021
Tau misfolding and assembly is linked to a number of neurodegenerative diseases collectively described as tauopathies, including Alzheimer’s disease (AD) and Parkinson’s disease.
Chad A. Sallaberry, Barbie J. Voss, Jaroslaw Majewski, Jaroslaw Majewski, Jaroslaw Majewski, Jacek Biernat, Eckhard Mandelkow, Eckhard Mandelkow, Eckhard Mandelkow, Eva Y. Chi, Crystal M. Vander Zanden   +10 more
doaj   +1 more source