Results 91 to 100 of about 216,066 (287)

Effect of fibrinogen concentration on the velocity of platelet aggregation.

, 1991
The relationship between fibrinogen binding to its receptor and platelet aggregation has been investigated by comparing 125I-fibrinogen binding and aggregation velocities of gel-filtered platelets in the presence of adenosine diphosphate (ADP ...
De Cristofaro, Raimondo, De Candia, Erica, Landolfi, Raffaele, Rocca, Bianca   +3 more
core  

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

Impact of the Intraoperative Use of Fibrinogen Concentrate for Hypofibrinogenemia during Thoracic Aortic Surgery [PDF]

, 2015
2015-02Thoracic aortic surgery often causes massive bleeding due to coagulopathy. Hypofibrinogenemia is one of the major causative factors, but the utility of the intraoperative administration of fibrinogen concentrate has not yet been proven. The aim of
OSHIMA, HIDEKI, YAGAMI, KEI, ITO, HIDEKI, USUI, AKIHIKO, FUJIMOTO, KAZURO, MUTSUGA, MASATO, TOKUDA, YOSHIYUKI, ABE, TOMONOBU, ARAKI, YOSHIMORI, TERAZAWA, SACHIE   +9 more
core   +1 more source

Penilaian Kadar Fibrinogen pada Subjek Sindroma Metabolik dan Obesitas

, 2013
Background: Fibrinogen plays an important role in the process of thrombosis both primary (platelets aggregation) and secondary (blood coagulation), and also play a role in increasing blood viscosity thus spur the process of the formation of the ...
Handayani, Tut Wuri
core  

“No End Point Detected”: A Unique Coagulation Profile Unmasking Dysfibrinogenemia

Case Reports in Hematology
Dysfibrinogenemia is a rare qualitative fibrinogen disorder that can present with bleeding, thrombosis, or both. We report a case of a young woman with first-trimester pregnancy loss and severe hemorrhage, whose coagulation tests reported “no end point ...
Kelsey Uminski, Xiu Yan Jiang
doaj   +1 more source

3D fibrinogen inhibits IFN-γ-induced apoptosis in hepatoma cells via the Nanog/STAT1/IRF1 signaling axis

Journal of Radiation Research and Applied Sciences
Objectives: Fibrinogen and interferon-γ (IFN-γ) are key extracellular matrix components and inflammatory cytokines present in tumor tissues. Recent research has demonstrated that fibrinogen promotes tumor cell proliferation and enhances anti-apoptotic ...
Hongxia Li
doaj   +1 more source

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

Studies on Genetic Polymorphism in Human Fibrinogen Gamma Chain [PDF]

, 1995
In the gene of human fibrinogen gamma chain, nucleotide poly(di)morphism has been reported at eight different positions. Among them, nucleotide 2543 is the middle base of the codon which encords residue 88 resulting in an amino acid substitution of ...
奥村, 伸生, 降旗, 謙一, 寺澤, 文子   +2 more
core  

Beyond Charge: Field‐Effect Transistors in Multimodal Biosensing Platforms for Biomolecular Interaction Studies

Advanced Electronic Materials, EarlyView.
This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler, Ciril Reiner‐Rozman, Christoph Kleber, Jakub Dostalek, Wolfgang Knoll   +4 more
wiley   +1 more source