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2020
Fibrinogen is a large glycoprotein, synthesized primarily in the liver. With a normal plasma concentration of 1.5-3.5 g/L, fibrinogen is the most abundant blood coagulation factor. The final stage of blood clot formation is the conversion of soluble fibrinogen to insoluble fibrin, the polymeric scaffold for blood clots that stop bleeding (a protective ...
John W. Weisel +3 more
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Fibrinogen is a large glycoprotein, synthesized primarily in the liver. With a normal plasma concentration of 1.5-3.5 g/L, fibrinogen is the most abundant blood coagulation factor. The final stage of blood clot formation is the conversion of soluble fibrinogen to insoluble fibrin, the polymeric scaffold for blood clots that stop bleeding (a protective ...
John W. Weisel +3 more
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Annual Review of Biochemistry, 1975
Fibrinogen is a soluble plasma protein that is converted to polymeric fibrin in response to damage to the vascular system. The clotting process is initiated when platelets aggregate at the wound site. Their disruption releases biologically active amines and a proteolytic cascade follows which culminates in the conversion of fibrinogen to fibrin.
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Fibrinogen is a soluble plasma protein that is converted to polymeric fibrin in response to damage to the vascular system. The clotting process is initiated when platelets aggregate at the wound site. Their disruption releases biologically active amines and a proteolytic cascade follows which culminates in the conversion of fibrinogen to fibrin.
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European Heart Journal, 1995
As evidence accumulates to implicate fibrinogen as a risk factor for cardiovascular disease (CVD) it becomes important to characterize the levels and correlates of fibrinogen in diverse populations. Knowledge of the correlates of fibrinogen may help researchers to disentangle the independent contribution of elevated fibrinogen concentrations to CVD ...
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As evidence accumulates to implicate fibrinogen as a risk factor for cardiovascular disease (CVD) it becomes important to characterize the levels and correlates of fibrinogen in diverse populations. Knowledge of the correlates of fibrinogen may help researchers to disentangle the independent contribution of elevated fibrinogen concentrations to CVD ...
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Fibrinogen Amsterdam, Another Hereditary Abnormality of Fibrinogen
British Journal of Haematology, 1971Summary. A coagulation defect, characterized by a prolonged thrombin and pro‐thrombin time, was discovered in a family without haemorrhagic diathesis. The disorder is caused by a delayed aggregation of fibrin monomers. Patient's and normal purified fibrin monomers showed the same aggregation properties, but the patient's fibrin monomers aggregated ...
J. Vreeken, Catherine L. Janssen
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Chicken Fibrinogen and Human Fibrinogen [PDF]
Thrombosis and Haemostasis, 1973 SummaryIn order to investigate the immunological features of chicken fibrinogen and to compare them with human fibrinogen, monospecific rabbit antichicken and antihuman fibrinogen antisera have been prepared. Both antisera agglutinated human tanned red cells coated with human fibrinogen.
Marie-Claude Guillin +3 more
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Fibrinogen and fibrinogen-related peptides in cancer
1984At a previous International Symposium on Plasma Protein Metabolism1 we presented evidence that patients with advanced carcinomas of the lung, pancreas and liver metabolise fibrinogen abnormally. Figure 13.1 shows the overall schema for fibrinogen synthesis, distribution and metabolism which we used to obtain that evidence2. In health, fibrinogen mainly,
Betty Kao +3 more
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Fibrinogen Concentrates for Acquired Fibrinogen Deficiencies?
Seminars in Thrombosis and Hemostasis, 2016Surgical bleeding has been decreasing steadily for the last 20 years, but there are still some hemorrhagic procedures occurring in scheduled surgical settings and emergency procedures. The interest in potent hemostatic agents has recently focused on fibrinogen concentrates.
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2005
Fibrinogen is a large, complex, fibrous glycoprotein with three pairs of polypeptide chains linked together by 29 disulfide bonds. It is 45 nm in length, with globular domains at each end and in the middle connected by alpha-helical coiled-coil rods. Both strongly and weakly bound calcium ions are important for maintenance of fibrinogen's structure and
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Fibrinogen is a large, complex, fibrous glycoprotein with three pairs of polypeptide chains linked together by 29 disulfide bonds. It is 45 nm in length, with globular domains at each end and in the middle connected by alpha-helical coiled-coil rods. Both strongly and weakly bound calcium ions are important for maintenance of fibrinogen's structure and
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Fibrinogen ‘Haifa’ – A New Fibrinogen Variant
Pathophysiology of Haemostasis and Thrombosis, 1983A 30-year-old female presenting with arterial occlusions of the lower limbs was discovered to have a markedly abnormal thrombin time and reptilase time. Further investigations revealed the presence of a qualitatively abnormal fibrinogen. Two other family members who were completely asymptomatic had similar defects.
I Tatarsky +4 more
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