Results 61 to 70 of about 1,131,844 (424)
Challenges for Clinical Drug Development in Pulmonary Fibrosis
Frontiers in Pharmacology, 2022 Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium. Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a number of which are characterized by progressive pulmonary fibrosis ...
Eric S. White +4 more
doaj +1 more source
Cell Sequence and Mitosis Affect Fibroblast Directional Decision-Making during Chemotaxis in Tissue-Mimicking Microfluidic Mazes [PDF]
Pham, Q.L., Rodrigues, L.N., Maximov, M.A. et al. Cel. Mol.
Bioeng. (2018), 2017 Directed fibroblast migration is central to highly proliferative processes in regenerative medicine and developmental biology, such as wound healing and embryogenesis. However, the mechanisms by which single fibroblasts affect each other's directional decisions, while chemotaxing in microscopic tissue pores, are not well understood.
arxiv +1 more source
Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. [PDF]
, 2018 Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown.
Aguirre, Aitor +19 more
core +3 more sources
Cardiac Fibrosis: The Fibroblast Awakens.
Circulation Research, 2016 Myocardial fibrosis is a significant global health problem associated with nearly all forms of heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is responsible for the homeostasis of the extracellular matrix; however ...
Joshua G. Travers +4 more
semanticscholar +1 more source
Cell migration guided by a groove with branches
Journal of Biomechanical Science and Engineering, 2017 Cell migration is an important process both in physiological and pathological conditions. Migrating cells in vivo respond to various extracellular environmental factors and change their migratory behavior.
Hiromi MIYOSHI +5 more
doaj +1 more source
Presence and localization of a 30-kDa basic fibroblast growth factor-like protein in rodent testes [PDF]
, 1991 We have used a recently characterized rabbit antiserum against basic fibroblast growth factor (bFGF), which recognizes various forms of bFGF, to examine the presence and localization of bFGF in the testes of adult rats and mice and the 5-day-old rat.
Gratzl, Manfred +4 more
core +1 more source
Annual Review of Physiology, 2020 Cardiac fibrosis is a pathological condition that occurs after injury and during aging. Currently, there are limited means to effectively reduce or reverse fibrosis.
M. Tallquist
semanticscholar +1 more source
Frontiers in Oncology, 2021 This investigation was conducted to elucidate whether atractylenolide-I (ATL-1), which is the main component of Atractylodes macrocephala Koidz, can sensitize triple-negative breast cancer (TNBC) cells to paclitaxel and investigate the possible mechanism
Meng Wang +5 more
doaj +1 more source
Fibroblast mediated dynamics in diffusively uncoupled myocytes -- a simulation study using 2-cell motifs [PDF]
arXiv, 2023 In healthy hearts myocytes are typically coupled to nearest neighbours through gap junctions. Under pathological conditions such as fibrosis, or in scar tissue, or across ablation lines myocytes can uncouple from their neighbours. Electrical conduction may still occur via fibroblasts that not only couple proximal myocytes but can also couple otherwise ...
arxiv
Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas [PDF]
, 2019 BACKGROUND Head and neck squamous cell carcinoma (HNSCC) is considered to be a progressive disease resulting from alterations in multiple genes regulating cell proliferation and differentiation like receptor tyrosine kinases (RTKs) and members of the ...
Bergmann, C. +5 more
core +2 more sources