Results 61 to 70 of about 510,893 (315)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review

Frontiers in Oncology, 2019
Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin. This neoplasia features aggressive behavior, resulting in a 5-year overall survival rate of 40%. In 2008, Feng et al.
Thibault Kervarrec, Thibault Kervarrec, Thibault Kervarrec, Mahtab Samimi, Mahtab Samimi, Serge Guyétant, Serge Guyétant, Bhavishya Sarma, Jérémy Chéret, Emmanuelle Blanchard, Emmanuelle Blanchard, Patricia Berthon, David Schrama, Roland Houben, Antoine Touzé   +14 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Regulation of Growth of Fibroblasts

Journal of Investigative Dermatology, 1978
Present knowledge on regulation of fibroblast growth is based on in vitro culture of fibroblasts from different sources. The research has focused on 2 problems: identification of the signal that reaches the fibroblast from outside and tells it to grow and identification of metabolic reactions inside the cell that commit it to initiate DNA synthesis ...
Robert W. Holley, Hans‐Jürgen Ristow, Trudy O. Messmer   +2 more
openaire   +2 more sources

Cardiac Fibroblast p38 MAPK: A Critical Regulator of Myocardial Remodeling

Journal of Cardiovascular Development and Disease, 2019
The cardiac fibroblast is a remarkably versatile cell type that coordinates inflammatory, fibrotic and hypertrophic responses in the heart through a complex array of intracellular and intercellular signaling mechanisms.
Neil A. Turner, Nicola M. Blythe
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Anoctamin 3: A Possible Link between Cluster Headache and Ca²⁺ Signaling

Brain Sciences, 2019
Cluster headache is a severe primary headache characterized by extremely painful attacks of unilateral headache. Verapamil is commonly used as a prophylactic treatment with good effect.
Caroline Ran, Carmen Fourier, Donia Arafa, Franziska Liesecke, Christina Sjöstrand, Elisabet Waldenlind, Anna Steinberg, Andrea Carmine Belin   +7 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Inhibition of Circulating Exosomal miRNA-20b-5p Accelerates Diabetic Wound Repair

International Journal of Nanomedicine, 2021
Kai Chen, Tao Yu, Xin Wang Department of Orthopedic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, People’s Republic of ChinaCorrespondence: Xin Wang; Tao YuDepartment of Orthopedic Surgery, Tongji Hospital, Tongji
Chen K, Yu T, Wang X
doaj  

The role of liquid smoke coconut shell in the proliferation phase of an oral traumatic ulcer [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2020
Context: Liquid smoke coconut shell (LS-CS) contains phenolic compounds that are able to promote wound healing by interfering with the inflammation phase of wound healing. The homeostatic mechanism that decreases the inflammation releases a growth factor
Nurina Febriyanti Ayuningtyas, Meircurius Dwi Condro Surboyo, Diah Savitri Ernawati, Adiastuti Endah Parmadiati, Hening Tuti Hendarti, Fatma Yasmin Mahdani, Saka Winias, Fitriatuz Zakia, Indira Arella Harianto   +8 more
doaj