Results 131 to 140 of about 1,957,077 (351)

PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation.

, 2016
The Notch/CSL pathway plays an important role in skin homeostasis and carcinogenesis. CSL, the key effector of canonical Notch signaling endowed with an intrinsic transcription repressive function, suppresses stromal fibroblast senescence and Cancer ...
Kim, D.E., Dotto, G.P., Jo, S.H., Clocchiatti, A., Jo SH, Kim DE, Clocchiatti A, Dotto GP   +7 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Classification of differentially activated groups of fibroblasts using morphodynamic and motile features

APL Bioengineering
Fibroblasts play essential roles in cancer progression, exhibiting activation states that can either promote or inhibit tumor growth. Understanding these differential activation states is critical for targeting the tumor microenvironment (TME) in cancer ...
Minwoo Kang, Chanhong Min, Somayadineshraj Devarasou, Jennifer H. Shin   +3 more
doaj   +1 more source

Rapid normal fibroblast‐tumor crosstalk promotes cancer‐associated fibroblast‐like activation and attenuates mitomycin C cytotoxicity in bladder cancer [PDF]

Normal fibroblasts (NFs) are among the earliest stromal cells encountered by bladder cancer cells during invasion into the lamina propria, yet their contribution to tumor progression and intravesical chemotherapy response remains poorly defined. Here, we
Jinhui Gao, Eleanor Stride, John Hines, Richard T. Bryan, Cindy Xinyu Ji, Ci Ren, Jennifer L. Rohn, Bryan, R.T., Ren, C., Hines, John, Stride, Eleanor, Ji, C.X., Rohn, J.L., Ren, Ci, Ji, Cindy Xinyu, Bryan, Richard T.; id_orcid, Rohn, Jennifer L., Stride, E., Hines, J., Gao, Jinhui, Gao, J.   +20 more
core   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

CAR T cells targeting fibroblast activation protein-α for the treatment of pulmonary fibrosis [PDF]

Ying Chen, Qian Zhang, Juanjuan Wu, Di Xu, Cong Wei, Xiaoyan Gao, Shi Chen, Chenghong Li, Shuqiao Gao, Haikui Bian, Shuang Liu, Fajiu Li   +11 more
openalex   +1 more source

A novel fibroblast activation protein-targeted near-infrared fluorescent off-on probe for cancer cell detection, &ITin vitro&IT and &ITin vivo &ITimaging

, 2018
A new hemicyanine-based fibroblast activation protein-targeted near-infrared fluorescent probe is designed and it shows high selectivity and sensitivity to cancer cell detection, and in vitro and in vivo imaging.
Xiang, Lingchao, Li, Zihou, Xing, Jie, Xia, Yuanzhi, Wu, Aiguo, Yu, Zhangsen, Ye, Yufan, Zou, Ruifen, Gong, Qiuyu   +8 more
core  

The Role Of Calcineurin/nfat Signaling In Fibroblast Homeostasis And Activation [PDF]

, 2019
Fibroblast activation is a crucial step in tumor growth and metastatic progression; activated fibroblasts remodel extracellular matrix (ECM) in primary tumor and metastatic microenvironments, exerting both pro- and anti-tumorigenic effects.
Lieberman, Allyson Elizabeth, Lieberman, Allyson   +1 more
core