Fibroblast Activation Protein Alpha (FAPα) in Fibrosis: Beyond a Perspective Marker for Activated Stromal Cells? [PDF]
Biomolecules, 2023 The development of tissue fibrosis is a complex process involving the interaction of multiple cell types, which makes the search for antifibrotic agents rather challenging.
Nataliya Basalova +4 more
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Imaging of Fibroblast Activation Protein Alpha Expression in a Preclinical Mouse Model of Glioma Using Positron Emission Tomography [PDF]
Molecules, 2020 Glioblastoma multiforme (GBM) is the most aggressive glioma of the primary central nervous system. Due to the lack of effective treatment options, the prognosis for patients remains bleak.
Darpan N. Pandya +6 more
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Genetic ablation of fibroblast activation protein alpha attenuates left ventricular dilation after myocardial infarction. [PDF]
PLoS ONE, 2021 IntroductionRegulating excessive activation of fibroblasts may be a promising target to optimize extracellular matrix deposition and myocardial stiffness.
Daniel B Hoffmann +5 more
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The fibroblast activation protein alpha as a biomarker of pulmonary fibrosis [PDF]
Frontiers in MedicineIdiopathic pulmonary fibrosis (IPF) is a rare, chronic, and progressive interstitial lung disease with an average survival of approximately 3 years. The evolution of IPF is unpredictable, with some patients presenting a relatively stable condition with ...
Philomène Lavis +6 more
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Fibroblast Activation Protein-Alpha is a Prognostic Biomarker Associated With Ferroptosis in Stomach Adenocarcinoma [PDF]
Frontiers in Cell and Developmental Biology, 2022 Background: The potential role of fibroblast activation protein-alpha (FAP) in modulating the progression and invasion of stomach adenocarcinoma (STAD) has not yet been comprehensively investigated. This study aimed to explore the role of FAP in STAD and
Zejian Lyu +16 more
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Protein-based Radiopharmaceuticals that target fibroblast activation protein alpha: a review of current progress [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Fibroblast activation protein alpha (FAP) is a serine protease that is expressed at basal levels in benign tissues but is overexpressed in a variety of pathologies, including cancer.
Abdelrahman Homedan +3 more
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Dental Tissue and Stem Cells Revisited: New Insights From the Expression of Fibroblast Activation Protein-Alpha [PDF]
Frontiers in Cell and Developmental Biology, 2020 Fibroblast activation protein-α (FAPα) is a membrane protein with dipeptidyl-peptidase and type I collagenase activity and is expressed during fetal growth.
Ronald B. Driesen +19 more
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Role of Fibroblast Activation Protein Alpha in Fibroblast-like Synoviocytes of Rheumatoid Arthritis
Iranian Journal of Allergy, Asthma and Immunology, 2021 Fibroblast-like synoviocytes (FLSs) have been introduced in recent years as a key player in the pathogenesis of rheumatoid arthritis (RA), but the exact mechanisms of their transformation and intracellular pathways have not yet been determined.
Mohammad Javad Mousavi +10 more
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Colorectal cancer cell intrinsic fibroblast activation protein alpha binds to Enolase1 and activates NF-κB pathway to promote metastasis [PDF]
Cell Death and Disease, 2021 Fibroblast activation protein alpha (FAP) is a marker of cancer-associated fibroblast, which is also expressed in cancer epithelial cells. However, the role of FAP in colorectal cancer (CRC) cells remains to be elucidated.
Ziming Yuan +14 more
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Stromal fibroblast activation protein alpha promotes gastric cancer progression via epithelial-mesenchymal transition through Wnt/ β-catenin pathway [PDF]
BMC Cancer, 2018 Background To investigate the influence of fibroblast activation protein alpha (FAP) derived from cancer-associated fibroblasts (CAFs), as well as potential mechanism of epithelial mesenchymal transition (EMT), on gastric cancer (GC) progression. Methods
Jiuyang Liu +7 more
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