Results 1 to 10 of about 280,358 (112)
Pharmaceuticals, 2021 Over the past decade, the tumor microenvironment (TME) has become a new paradigm of cancer diagnosis and therapy due to its unique biological features, mainly the interconnection between cancer and stromal cells.
Surachet Imlimthan +6 more
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Frontiers in Bioengineering and Biotechnology, 2022 Recently, fibroblast activation protein (FAP), an overexpressed transmembrane protein of activated fibroblast in pulmonary fibrosis, has been considered as the new target for diagnosing and treating pulmonary fibrosis.
Qi Fang +10 more
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Fibroblast activation protein-based theranostics in pancreatic cancer
Frontiers in Oncology, 2022 Fibroblast activation protein-α (FAP) is a type II transmembrane serine protease that has specific endopeptidase activity. Given its well-established selective expression in the activated stromal fibroblasts of epithelial cancers, although not in ...
Chien-shan Cheng +9 more
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Fibroblast activation protein inhibitor (FAPI) PET imaging in pulmonary fibrosis: pathophysiology, clinical utility, and emerging theranostic applications [PDF]
Respiratory ResearchPulmonary fibrosis arises from a dysregulated wound-healing response in which activated fibroblasts drive excessive extracellular matrix deposition and irreversible lung architectural distortion.
Ali Al-waqeerah +5 more
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Targeting fibroblast activation protein-α to treat renal fibrosis [PDF]
Cellular & Molecular Biology LettersBackground Renal fibrosis is the common outcome of chronic renal disease. Currently, there are no effective therapies. Fibroblast activation and extracellular matrix accumulation are key processes driving renal fibrosis.
Li Gong +17 more
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18F-labeled tracers targeting fibroblast activation protein
EJNMMI Radiopharmacy and Chemistry, 2021 Background Cancer-associated fibroblasts are found in the stroma of epithelial tumors. They are characterized by overexpression of the fibroblast activation protein (FAP), a serine protease which was already proven as attractive target for chelator-based
Thomas Lindner +11 more
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EJNMMI Research, 2023 Background The diagnostic accuracy of [18F]-fluorodeoxyglucose ([18F]-FDG) positron emission tomography imaging in accurately identifying thyroid lesions is limited, primarily due to the physiological uptake of normal head and neck tissues and ...
Yuhua Wang +3 more
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Frontiers in Oncology, 2023 PurposeThis study aimed to compare the diagnostic performance of [68Ga]Ga-FAPI-04 PET/CT and [18F]F-FDG PET/CT in primary and metastatic colorectal cancer (CRC) lesions.MethodsThis single-center preliminary clinical study (NCT04750772) was conducted at ...
Xinfeng Lin +9 more
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Correction: Targeting fibroblast activation protein-α to treat renal fibrosis [PDF]
Cellular & Molecular Biology LettersLi Gong +17 more
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Oxidatively stressed extracellular microenvironment drives fibroblast activation and kidney fibrosis
Redox Biology, 2023 Kidney fibrosis is associated with tubular injury, oxidative stress and activation of interstitial fibroblasts. However, whether these events are somehow connected is poorly understood.
Li Li +13 more
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