Results 11 to 20 of about 280,507 (256)
Fibroblast Activation Protein Expression in Sarcomas [PDF]
Sarcoma, 2023 Objectives. Fibroblast activation protein alpha (FAP) is highly expressed by cancer-associated fibroblasts in multiple epithelial cancers. The aim of this study was to characterize FAP expression in sarcomas to explore its potential utility as a diagnostic and therapeutic target and prognostic biomarker in sarcomas. Methods.
Jacquelyn N. Crane +14 more
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The application of FAPI-targeted theranostics in pancreatic cancer: a narrative review
Journal of Pancreatology, 2022 Pancreatic cancer is one of the most lethal malignancies in the world. Cancer-associated fibroblasts are one of the main components of tumor microenvironment in pancreatic cancer and play an essential role in tumor progression.
Meixi Liu +3 more
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Frontiers in Chemistry, 2022 Purpose: 68Ga-labeled fibroblast activation protein inhibitors, such as [68Ga]Ga-DOTA-FAPI-04 and [68Ga]Ga-DOTA-FAPI-46, have been successfully applied in positron emission tomography imaging of various tumor types.
Cheng Wang +9 more
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Nature Communications, 2022 Activated hepatic stellate cells contribute towards the pathogenesis of liver fibrosis, and overexpress fibroblast activation protein. Here the authors report a targeted peptide-delivery system in which fibroblast activation protein liberates the ...
Jaiwoo Lee +3 more
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Fibroblast activation protein [PDF]
Cancer Biology & Therapy, 2012 The concept of targeting antigens selectively expressed on the surface of tumor capillary endothelial cells or in tumor stroma has emerged as a promising strategy for cancer therapeutics. Identification of stromal targets for anticancer therapy and development of selective inhibitors of these targets are of great clinical interest.
Rui, Liu +4 more
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Isolation of Fibroblast-Activation Protein-Specific Cancer-Associated Fibroblasts [PDF]
BioMed Research International, 2017 The current study is to develop a gentle and efficient method for purification of fibroblast-activation protein positive (FAP+) cancer-associated fibroblasts (CAFs) from tumor tissues. Fresh tissues were isolated from BALB/c-Nude mice bearing human liver cancer cell line (HepG2), fully minced and separated into three parts, and digested with trypsin ...
Yingying Huang +10 more
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Fibroblast activation protein and the tumour microenvironment: challenges and therapeutic opportunities. [PDF]
Oncol RevLee HH, Al-Ogaili Z.
europepmc +2 more sources
Expression of fibroblast-activation protein in keloid tissue and its clinical significance
Pifu-xingbing zhenliaoxue zazhi, 2020 Objective: To investigate the expression of fibroblast-activation protein(FAP) in keloid tissue and its role in the development of keloid. Methods: Immunochemical staining was used to evaluate the expression of FAP in 30 cases of keloid tissue (case ...
Yu-xiong ZOU, Ming-chun CHEN, Li-da XU
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Biomolecules, 2023 The development of tissue fibrosis is a complex process involving the interaction of multiple cell types, which makes the search for antifibrotic agents rather challenging.
Nataliya Basalova +4 more
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Automated Radiosynthesis and Micro PET/CT Imaging of 18F-FAPI-42
Journal of Isotopes, 2023 Fibroblast activation protein is highly expressed in most epithelial malignant tumors. FAP inhibitor (FAPI) has been used in the early diagnosis of tumors after radionuclide labeling.
WANG Hua;WANG Meng;HUANG Shun;SUN Penghui;HU Kongzheng;XIANG Xianhong;LIN Weiyuan;ZHI Shengfang;TANG Ganghua;HAN Yanjiang
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