Results 21 to 30 of about 280,507 (256)

Highlights of Strategies Targeting Fibroblasts for Novel Therapies for Rheumatoid Arthritis

Frontiers in Medicine, 2022
Synovial fibroblasts of rheumatoid arthritis (RA) play a critical role in perpetuation of chronic inflammation by interaction with immune and inflammatory cells and in cartilage and bone invasion, but current therapies for RA are not directly targeted ...
Cong-Qiu Chu
doaj   +1 more source

Radioligands Targeting Fibroblast Activation Protein (FAP) [PDF]

Cancers, 2021
Targeting fibroblast activation protein (FAP) in cancer-associated fibroblasts (CAFs) has attracted significant attention in nuclear medicine. Since these cells are present in most cancerous tissues and FAP is rarely expressed in healthy tissues, anti-FAP tracers have a potential as pan-tumor agents.
Lindner, Thomas, Giesel, Frederik L., Kratochwil, Clemens, Serfling, Sebastian E.   +3 more
openaire   +3 more sources

Role of Fibroblast Activation Protein Alpha in Fibroblast-like Synoviocytes of Rheumatoid Arthritis

Iranian Journal of Allergy, Asthma and Immunology, 2021
Fibroblast-like synoviocytes (FLSs) have been introduced in recent years as a key player in the pathogenesis of rheumatoid arthritis (RA), but the exact mechanisms of their transformation and intracellular pathways have not yet been determined.
Mohammad Javad Mousavi, Elham Farhadi, Mohammad Vodjgani, Jafar Karami, Mohammad Naghi Tahmasebi, Arash Sharafat Vaziri, Marzieh Asgari, Nima Rezaei, Shayan Mostafaei, Ahmadreza Jamshidi, Mahdi Mahmoudi   +10 more
doaj   +1 more source

Effects of bone morphogenetic protein 4 on TGF-β1-induced cell proliferation, apoptosis, activation and differentiation in mouse lung fibroblasts via ERK/p38 MAPK signaling pathway [PDF]

PeerJ, 2022
Fibroblasts, in particular myofibroblasts, are the critical effector cells in idiopathic pulmonary fibrosis (IPF), a deadly lung disease characterized by abnormal lung remodeling and the formation of “fibroblastic foci”.
Zhou Cai, Hua Guo, Jing Qian, Wei Liu, Yuanyuan Li, Liang Yuan, You Zhou, Ran Lin, Xiaohui Xie, Qiong Yang, Guoying Wu, Qiongqiong Li, Li Zhao, Fei Liu, Jian Wang, Wenju Lu   +15 more
doaj   +2 more sources

Recent clinical advances in fibroblast activation protein targeted radioligand therapy for solid tumors. [PDF]

Front Nucl Med
Wu X, Wang Y, Li Y, Hu W.
europepmc   +2 more sources

Deletion of fibroblast activation protein provides atheroprotection [PDF]

Cardiovascular Research, 2020
AbstractAimsFibroblast activation protein (FAP) is upregulated at sites of tissue remodelling including chronic arthritis, solid tumours, and fibrotic hearts. It has also been associated with human coronary atherosclerotic plaques. Yet, the causal role of FAP in atherosclerosis remains unknown. To investigate the cause–effect relationship of endogenous
Sokrates Stein, Julien Weber, Stefanie Nusser-Stein, Jürgen Pahla, Hui E Zhang, Shafeeq A Mohammed, Sara Oppi, Daniel S Gaul, Francesco Paneni, Anne Tailleux, Bart Staels, Ferdinand von Meyenn, Frank Ruschitzka, Mark D Gorrell, Thomas F Lüscher, Christian M Matter   +15 more
openaire   +4 more sources

Fibroblast activation protein in liver fibrosis

Frontiers in Bioscience, 2019
Fibroblast activation protein (FAP) belongs to the dipeptidyl peptidase IV (DPP4; CD26) gene family. Other related genes in this family of enzyme include DPP4, 8 and 9. The FAP serine protease has the rare property of both dipeptidyl peptidase and endopeptidase activities capable of cleaving the post-proline bond at two or more residues from the N ...
Angelina J, Lay, Hui Emma, Zhang, Geoffrey William, McCaughan, Mark Douglas, Gorrell   +3 more
openaire   +2 more sources

Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21 [PDF]

Journal of Biological Chemistry, 2016
FGF21 is a stress-induced hormone with potent anti-obesity, insulin-sensitizing, and hepatoprotective properties. Although proteolytic cleavage of recombinant human FGF21 in preclinical species has been observed previously, the regulation of endogenously produced FGF21 is not well understood.
Diana Ronai, Dunshee, Travis W, Bainbridge, Noelyn M, Kljavin, Jose, Zavala-Solorio, Amy C, Schroeder, Ruby, Chan, Racquel, Corpuz, Manda, Wong, Wei, Zhou, Gauri, Deshmukh, Justin, Ly, Daniel P, Sutherlin, James A, Ernst, Junichiro, Sonoda   +13 more
openaire   +2 more sources

The Latest Developments in Imaging of Fibroblast Activation Protein [PDF]

Journal of Nuclear Medicine, 2020
Fibroblast activation protein (FAP), a membrane-anchored peptidase, is highly expressed in cancer-associated fibroblasts in more than 90% of epithelial tumors and contributes to progression and worse prognosis of different cancers. Therefore, FAP is considered a promising target for radionuclide-based approaches for diagnosis and treatment of tumors ...
Annette, Altmann, Uwe, Haberkorn, Jens, Siveke   +2 more
openaire   +2 more sources

Identification and characterization of the promoter of fibroblast activation protein [PDF]

Frontiers in Bioscience, 2010
Fibroblast activation protein (FAP) is a type II integral membrane glycoprotein belonging to the serine protease family. It is selectively expressed by tumor stromal fibroblasts and transiently in the fibroblasts of healing wounds. FAP has been shown to modulate growth, differentiation, adhesion, and metastasis of tumor cells. Despite the importance of
Jiping, Zhang, Matthildi, Valianou, Jonathan D, Cheng   +2 more
openaire   +2 more sources