Results 1 to 10 of about 5,296,642 (245)

Gallium-68 fibroblast activation protein inhibitor positron emission tomography in cardiovascular disease [PDF]

Frontiers in Nuclear Medicine, 2023
Gallium-68 fibroblast activation protein inhibitor [(68Ga)Ga-FAPI] is a new radiopharmaceutical positioning itself as the preferred agent in patients with malignant tumours, competing with 2-Deoxy-2-[18F]fluoro-d-glucose [2-(18F)FDG] using positron ...
Dineo Mpanya, Mike Sathekge, Mike Sathekge, Eric Klug, Eric Klug, Jenna Damelin, Stuart More, Bawinile Hadebe, Bawinile Hadebe, Mariza Vorster, Mariza Vorster, Nqoba Tsabedze   +11 more
doaj   +2 more sources

New Frontiers in Cancer Imaging and Therapy Based on Radiolabeled Fibroblast Activation Protein Inhibitors: A Rational Review and Current Progress

Pharmaceuticals, 2021
Over the past decade, the tumor microenvironment (TME) has become a new paradigm of cancer diagnosis and therapy due to its unique biological features, mainly the interconnection between cancer and stromal cells.
Surachet Imlimthan, Euy Sung Moon, Hendrik Rathke, Ali Afshar-Oromieh, Frank Rösch, Axel Rominger, Eleni Gourni   +6 more
doaj   +3 more sources

Fibroblast Activation Protein Inhibitor PET/CT in Gastric Cancer

PET Clinics, 2023
Like other major cancers, gastric cancer expresses fibroblast activation protein (FAP) in cancer-associated fibroblasts. Many recent studies have reported the utility and superiority of FAP inhibitor (FAPI)-PET over [18F]fluorodeoxyglucose (FDG)-PET in gastric cancers, from initial staging to recurrence detection.
Tadashi Watabe, Frederik L. Giesel
openaire   +4 more sources

Mesoporous Polydopamine Loaded Pirfenidone Target to Fibroblast Activation Protein for Pulmonary Fibrosis Therapy [PDF]

Frontiers in Bioengineering and Biotechnology, 2022
Recently, fibroblast activation protein (FAP), an overexpressed transmembrane protein of activated fibroblast in pulmonary fibrosis, has been considered as the new target for diagnosing and treating pulmonary fibrosis.
Qi Fang, Shaoyu Liu, Jiangyu Cui, Ruiyue Zhao, Qian Han, Peng Hou, Youcai Li, Jie Lv, Xiaoyao Zhang, Qun Luo, Xinlu Wang   +10 more
doaj   +2 more sources

Fibroblast Activation Protein Inhibitor (FAPI)-Based Theranostics

Pharmaceuticals
Fibroblast activation protein (FAP) is a serine protease selectively expressed in cancer-associated fibroblasts (CAFs), fibrotic tissues, and areas of active tissue remodeling, making it an attractive target for diagnostic imaging across a spectrum of ...
William Serumula, Venesen Pillay, Bawinile Hadebe, Mariza Vorster   +3 more
doaj   +3 more sources

Inhibitor-conjugated harmonic nanoparticles targeting fibroblast activation protein [PDF]

RSC Advances, 2019
Harmonic nanoparticles, functionalized with a selective inhibitor of FAP, provide imaging probes targeting the fibroblastic element of the tumor stroma.
Raphaël De Matos, Jérémy Vuilleumier, Christophe Mas, Samuel Constant, Davide Staedler, Sandrine Gerber-Lemaire   +5 more
openaire   +6 more sources

Based on small molecules: development and application of fibroblast activation protein inhibitors radiopharmaceutical in tumor precision therapy

Frontiers in Pharmacology
The discovery of biomarkers for malignant tumors is driving the development of new radiopharmaceuticals in nuclear medicine. The development and optimization of novel radiopharmaceuticals to occupy an increasingly important role in tumor diagnosis and ...
Yihui Luo, Haitian Fu, Haitian Fu, Chunjing Yu, Chunjing Yu   +4 more
doaj   +3 more sources

Fibroblast Upregulation of Vitamin D Receptor Represents a Self-Protective Response to Limit Fibroblast Proliferation and Activation during Pulmonary Fibrosis

Antioxidants, 2023
Dysregulation of vitamin D receptor (VDR) is implicated in chronic obstructive pulmonary disease. However, whether VDR dysregulation contributes to the development of pulmonary fibrosis remains largely unknown.
Juan Wei, Junhui Zhan, Hui Ji, Yitong Xu, Qingfeng Xu, Xiaoyan Zhu, Yujian Liu   +6 more
doaj   +2 more sources

Diagnostic value of [68Ga]Ga-FAPI-04 in patients with colorectal cancer in comparison with [18F]F-FDG PET/CT

Frontiers in Oncology, 2023
PurposeThis study aimed to compare the diagnostic performance of [68Ga]Ga-FAPI-04 PET/CT and [18F]F-FDG PET/CT in primary and metastatic colorectal cancer (CRC) lesions.MethodsThis single-center preliminary clinical study (NCT04750772) was conducted at ...
Xinfeng Lin, Yingjie Li, Shuailiang Wang, Yan Zhang, Xuetao Chen, Maomao Wei, Hua Zhu, Aiwen Wu, Zhi Yang, Xuejuan Wang   +9 more
doaj   +1 more source

The application of FAPI-targeted theranostics in pancreatic cancer: a narrative review

Journal of Pancreatology, 2022
Pancreatic cancer is one of the most lethal malignancies in the world. Cancer-associated fibroblasts are one of the main components of tumor microenvironment in pancreatic cancer and play an essential role in tumor progression.
Meixi Liu, Marcus Hacker, Li Huo, Xiang Li   +3 more
doaj   +1 more source