Results 31 to 40 of about 5,296,642 (245)

Involvement of tyrosine-specific protein kinase and protein kinase C in J774A.1 macrophage functions activated by Tinospora cordifolia

Journal of Ayurveda and Integrative Medicine, 2017
Background: Macrophages are the first line of defense and constitute important participant in the bi-directional interaction between innate and specific immunity. Macrophages are in a quiescent form and get activated when given a stimulus.
Priti More, Kalpana Pai
doaj   +1 more source

Small molecule receptor tyrosine kinase inhibitor of platelet-derived growth factor signaling (SU9518) modifies radiation response in fibroblasts and endothelial cells

BMC Cancer, 2006
Background Several small receptor tyrosine kinase inhibitors (RTKI) have entered clinical cancer trials alone and in combination with radiotherapy or chemotherapy. The inhibitory spectrum of these compounds is often not restricted to a single target. For
Lipson Kenneth E, Trinh Thuy, Plathow Christian, Ping Gong, Li Minglun, Hauser Kai, Krempien Robert, Debus Juergen, Abdollahi Amir, Huber Peter E   +9 more
doaj   +1 more source

Inhibition von FGFR, PDGFR und VEGFR hemmt Tumorwachstum, Angiogenese und Metastasierung des Pankreaskarzinoms in einem experimentellen Modell [PDF]

, 2013
Die Expression und Aktivierung von Rezeptor-Tyrosinkinasen (RTK) für fibroblast growth factor (FGF), platelet-derived growth factor (PDGF) und vascular endothelial growth factor (VEGF) konnten mit gesteigertem Tumorwachstum, Metastasierung und ...
Taeger, Johannes Kai
core   +1 more source

A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. [PDF]

, 2010
Viruses have evolved to evade the host's complement system. The open reading frames 4 (ORF4) of gammaherpesviruses encode homologs of regulators of complement activation (RCA) proteins, which inhibit complement activation at the level of C3 and C4 ...
Stewart, James P., Stipan, J., Adler, Heiko, James P Stewart, Adler Barbara, Adler, Barbara, Heiko Adler, Beatrix Steer, Barbara Adler, Jonjic Stipan, Stipan Jonjic, Steer, Beatrix, Steer Beatrix, Steer, B., Adler Heiko, Stewart James P., Adler, H., Adler, B., Jonjic, Stipan, James P. Stewart, Stewart, J.P.   +20 more
core   +1 more source

Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis

Frontiers in Immunology, 2021
A hallmark of chronic kidney disease is renal fibrosis, which can result in progressive loss of kidney function. Currently, there is no effective therapy for renal fibrosis.
Baihai Jiao, Changlong An, Melanie Tran, Hao Du, Penghua Wang, Dong Zhou, Yanlin Wang, Yanlin Wang, Yanlin Wang, Yanlin Wang   +9 more
doaj   +1 more source

Shear Stress Induces the Release of an Endothelial Elastase: Role in Integrin alpha(v)beta(3)-Mediated FGF-2 Release [PDF]

, 2011
Background/Aims: Laminar shear stress is an important stimulus in the endothelium-dependent control of vascular tone and of vascular remodeling processes.
Hennig, Theres, Christina Mogensen, Gloe, Torsten, Kirsch, Julian, Julian Kirsch, Torsten Gloe, Ulrich Pohl, Pohl, Ulrich, Theres Hennig, Mogensen, Christina   +9 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

ING4 (inhibitor of growth family, member 4) [PDF]

, 2011
Review on ING4 (inhibitor of growth family, member 4), with data on DNA, on the protein encoded, and where the gene is ...
Miranda, C, Greco, A
core   +1 more source

Selective Activity-Based Probes Targeting Fibroblast Activation Protein (FAP)

Proceedings, 2019
Fibroblast activation protein (FAP) is a type II transmembrane serine protease that belongs tothe dipeptidyl peptidase (DPP) family. [...]
Johannes Vrijdag, Anvesh Jallapally, An De Decker, Koen Janssen, Filipe Elvas, Steven Staelens, Ingrid De Meester, Koen Augustyns, Anne-Marie Lambeir, Pieter Van der Veken   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source