Oxidatively stressed extracellular microenvironment drives fibroblast activation and kidney fibrosis
Redox Biology, 2023 Kidney fibrosis is associated with tubular injury, oxidative stress and activation of interstitial fibroblasts. However, whether these events are somehow connected is poorly understood.
Li Li +13 more
doaj +4 more sources
Embryo-derive TNF promotes decidualization via fibroblast activation
eLife, 2023 Decidualization is a process in which endometrial stromal fibroblasts differentiate into specialized secretory decidual cells and essential for the successful establishment of pregnancy.
Si-Ting Chen +9 more
doaj +2 more sources
TRPML1 agonist ML-SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux. [PDF]
FEBS Open BioTGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Yao J +10 more
europepmc +4 more sources
The Role of Cardiac Fibrosis and Fibroblast Activation in Amyloid Light Chain (AL) Amyloidosis [PDF]
JACC: Basic to Translational ScienceSummary: Recent studies suggest that interactions between collagen and amyloid fibril may influence amyloid formation, matrix remodeling, and disease progression in cardiac amyloid light chain (AL) amyloidosis.
Shingo Narita, MD, PhD +7 more
doaj +2 more sources
Soluble St2 Induces Cardiac Fibroblast Activation and Collagen Synthesis via Neuropilin-1
Cells, 2020 Circulating levels of soluble interleukin 1 receptor-like 1 (sST2) are increased in heart failure and associated with poor outcome, likely because of the activation of inflammation and fibrosis.
Lara Matilla +14 more
doaj +3 more sources
Pharmaceuticals, 2021 Over the past decade, the tumor microenvironment (TME) has become a new paradigm of cancer diagnosis and therapy due to its unique biological features, mainly the interconnection between cancer and stromal cells.
Surachet Imlimthan +6 more
doaj +3 more sources
Multi-omics profiling reveals EMT-driven fibroblast activation in the renal injury niche [PDF]
Cellular and Molecular Life SciencesPersistent renal injury creates conditions for activating fibroblasts. However, due to the complexity of the renal injury microenvironment, the mechanisms driving fibroblast activation remain poorly understood.
Songmei Zhai +9 more
doaj +2 more sources
REV-ERB is essential in cardiac fibroblasts homeostasis
Frontiers in Pharmacology, 2022 REV-ERB agonists have shown antifibrotic effects in the heart and other organs. The function of REV-ERB in the cardiac fibroblasts remains unstudied. Here, we characterize the functional difference of REV-ERB in mouse embryonic fibroblasts and cardiac ...
Xiaokang Luo +11 more
doaj +1 more source
BMPER Ameliorates Renal Fibrosis by Inhibiting Tubular Dedifferentiation and Fibroblast Activation
Frontiers in Cell and Developmental Biology, 2021 Tubulointerstitial fibrosis is both a pathological manifestation of chronic kidney disease and a driving force for the progression of kidney disease. A previous study has shown that bone morphogenetic protein-binding endothelial cell precursor-derived ...
Ting Xie +5 more
doaj +1 more source
Metabolic Regulation of Fibroblast Activation and Proliferation during Organ Fibrosis
Kidney Diseases, 2022 Background: Activated fibroblasts are present in the injury response, tumorigenesis, fibrosis, and inflammation in a variety of tissues and myriad disease types.
Sudan Wang, Yan Liang, Chunsun Dai
doaj +1 more source